The gut microbiota has been established to play a crucial role in health and disease. We are focused on the virus component of the microbiome and how these viruses can interact with bacteria, other microorganisms and the human host system. We aim to elucidate the diversity and role of viruses in gut health and diseases such as Inflammatory Bowel Disease (IBD), and to utilise this knowledge to modulate the microbiome to improve health or reduce burden of gastrointestinal conditions.
We are particularly interested in bacteriophages, their genomic and taxonomic diversity, and how they interact with the gut microbiota. We are also interested in studying the drivers of viral community change in gastrointestinal disease.
We use a holistic approach of culture-dependent and computational methods to study the viruses in the human gut. Specifically, we are specialised in viromics (viral metagenomics) and genome-resolved investigations of gut viral communities to illuminate the dark matter in the virosphere.