Investigating the evolution of antimicrobial resistance
Our group is studying how antimicrobial resistance evolves in bacteria, and using this knowledge to prevent or eradicate microbial infection and develop new treatments and eradication options.
By understanding the conditions under which antimicrobial resistance can occur and the biological costs of evolving resistance, we can inform practices which will minimise selection for resistant mutants as well as developing novel methods to prevent and treat bacterial contamination and infection. We are particularly interested in methods to modulate biofilm formation.
Our research draws on our expertise in in vitro evolution experiments, antimicrobial susceptibility testing, efflux and cellular permeability assays as well as various biofilm assays, backed by functional genomics, transcriptomics and metabolomics.