Dr Arthur Thompson and his team at the IFR have uncovered new insights into how Salmonella is so well equipped to survive against our bodies’ defences. Building on a comprehensive survey of which genes are turned on in Salmonella, they have now extended the number of start sites defined for Salmonella genes and new non-coding RNAs. This has given the team a better understanding of how regulates its virulence genes associated with its ability to survive and grow inside macrophages.
Screenshot of our publicly available dRNA-seq data (http://opendata.ifr.ac.uk/salseq/) displayed in JBrowse
Reference: Ramachandran V.K., Shearer N., Thompson A. (2014) The primary transcriptome of Salmonella enterica serovar Typhimurium and its dependence on ppGpp during late stationary phase. PLOS ONE