Agatha Treveil

Postgraduate Student

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Systems Biology of Gut-Microbe Interactions

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As a PhD Student at the Earlham and Quadram Institutes (Norwich Research Park), my research focuses on understanding the effect of the gut commensal Bifidobacteria on host intestinal cells. The project combines a range of computational and experimental techniques to determine the impact of Bifidobacteria on host molecular signalling networks. In particular, I am using network biology and cell-type specific RNAseq data to study regulatory landscapes of small intestinal Paneth cells with and without the influence of Bifidobacteria.

Before starting my PhD I undertook a BSc in Biology from the University of Bath. During this time, I spent a year working in the Computational Biology division of biotech company Oxford Gene Technology. It was this work that captured my interest in Bioinformatics and Genomics and led me to carry out a PhD.

Olbei M,Hautefort I,Modos D,Treveil A,Poletti M,Gul L,Shannon-Lowe C,Korcsmaros T. (2021)

SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients

Frontiers in Immunology


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Treveil A,Bohar B,Sudhakar P,Gul L,Csabai L,Olbei M,Poletti M,Madgwick M,Andrighetti T,Hautefort I,Modos D,Korcsmaros T. (2021)

ViralLink: An integrated workflow to investigate the effect of SARS-CoV-2 on intracellular signalling and regulatory pathways

PLoS Computational Biology


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Püngel D., Treveil A., Dalby M. J., Caim S., Colquhoun I. J., Booth C., Ketskemety J., Korcsmaros T., van Sinderen D., Lawson M. A., Hall L. J.. (2020)

Bifidobacterium breve UCC2003 Exopolysaccharide Modulates the Early Life Microbiota by Acting as a Potential Dietary Substrate.

Nutrients, 12


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Kiu R,Treveil A,Harnisch L,Caim S,Leclaire C,van Sinderen D,Korcsmaros T,Hall L. (2020)

Bifidobacterium breve UCC2003 Induces a Distinct Global Transcriptomic Program in Neonatal Murine Intestinal Epithelial Cells.

iScience, 23, 101336


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Jones E., Matthews Z., Gul L., Sudhakar P., Treveil A., Divekar D., Buck J., Wrzesinski T., Jefferson M., Armstrong S., Hall L., Watson A., Carding S., Haerty W., Di Palma F., Mayer U., Powell P., Hautefort I., Wileman T., Korcsmaros T.. (2019)

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Disease Models and Mechanisms


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Treveil A., Sudhakar P., Matthews Z., Wrzesinski T., Jones E., Brooks J., Olbei M., Hautefort I., Hall L., Carding S., Mayer U., Powell P., Wileman T., Di Palma F., Haerty W., Korcsmaros T.. (2019)

Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approaches.

Molecular omics


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