Dr Alison Mather

Group Leader

Contact via email

Epidemiology, genomics and antimicrobial resistance of bacteria

Links/websites:

I am a Group Leader at the Institute and a Food Standards Agency Fellow, where my interests are the epidemiology, evolution and dynamics of foodborne and zoonotic bacteria, with a particular focus on antimicrobial resistance (AMR). I was awarded a BSc in biomedical toxicology and an MSc in epidemiology from the University of Guelph, followed by a PhD at the University of Glasgow, where I took an epidemiological and ecological approach to the study of AMR in E. coli, and in Salmonella from animals and humans.

After moving to the Wellcome Trust Sanger Institute, my work utilised whole genome sequencing (WGS) to examine, in the greatest resolution, the evolution and transmission of both bacteria and AMR between and within different host populations. This lead to important insights into the dynamics in Scotland of a globally distributed Salmonella epidemic, demonstrating that there were distinguishable bacterial populations in animals and humans. I have also applied these phylogenetic and comparative genomics techniques to other bacteria, including Shigella, Campylobacter, and Vibrio cholerae.

I was awarded a BBSRC Anniversary Future Leader fellowship at the University of Cambridge in 2015, where I used short and long-read sequencing to investigate the dynamics of AMR and cross-species transmission in Salmonella in Vietnam. I have also become very interested in the role of commensal bacteria as reservoirs of AMR genes, and used metagenome sequencing to try to quantify their contribution to the AMR burden of pathogens. In 2017 I moved to the Quadram Institute, where my group studies the epidemiology, evolution and AMR of pathogenic and commensal bacteria throughout the food chain.


Key Publications

Hunt, M.H., Mather, A.E., Sánchez-Busó, L., Page, A.J., Parkhill, J., Keane, J.A. and Harris, S.R. (2017) ARIBA: rapid antimicrobial resistance genotyping directly from sequencing reads. Microb. Gen.

Petrovska, L., Mather, A.E., AbuOun, M., Branchu, P., Harris, S.R., Connor, T., Hopkins, K.L., Underwood, A., Lettini, A.A., Page, A., Bagnall, M., Wain, J., Parkhill, J., Dougan, G., Davies, R. and Kingsley, R.A. (2016) Microevolution of monophasic Salmonella Typhimurium during epidemic, United Kingdom, 2005-2010. Emerg. Inf. Dis. 22. 617-624.

Mather, A.E., Vaughan, T.G. and French, N.F. (2015) Molecular approaches to understanding transmission and source attribution in non-typhoidal Salmonella and their application in Africa. Clin, Infect. Dis. 61 Suppl 4, S259-65.

Mather, A.E., Reid, S.W.J., Maskell, D.J., Parkhill, J., Fookes, M.C., Harris, S.R., Brown, D.J., Coia, J.E., Mulvey, M.R., Gilmour, M.W., Petrovska, L., de Pinna, E., Kuroda, M., Akiba, M., Izumiya, H., Connor, T.R., Suchard, M.A., Lemey, P., Mellor, D.J., Haydon, D.T. and Thomson, N.R. (2013) Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts. Science. 341. 1514-1517.

Mather, A.E., Matthews, L., Mellor, D.J., Reeve, R., Denwood, M.J., Boerlin, P., Reid-Smith, R.J., Brown, D.J., Coia, J.E., Browning, L.M., Haydon, D.T., and Reid, S.W.J. (2012) An ecological approach to assessing the epidemiology of antimicrobial resistance in animal and human populations. Proc. R. Soc. B. 279, 1630 – 1639.

Thuy Duong,Chung The,Do Hoang,Thanh Tuyen,Campbell JI,Van Minh,Le Phuc,Thi Hong,Minh Ngoc,Lan Vi,Mather A,Baker S. (2020)

Genomic serotyping, clinical manifestations, and antimicrobial resistance of non-typhoidal Salmonella gastroenteritis in hospitalized children in Ho Chi Minh City, Vietnam.

Journal of clinical microbiology


View Publication

Alm E,Broberg EK,Connor T,Hodcroft EB,Komissarov AB,Maurer-Stroh S,Melidou A,Neher RA,O'Toole Á,Pereyaslov D,Beerenwinkel N,Posada-Céspedes S,Jablonski KP,Ferreira PF,Topolsky I,Avic-upanc T,Korva M,Poljak M,Zakotnik S,Zorec TM,Bragstad K,Hungnes O,Stene-Johansen K,Reusken C,Meijer A,Vennema H,Ruiz-Roldán L,Bracho MA,García-González N,Chiner-Oms Á,Cancino-Muñoz I,Comas I,Goig GA,Torres-Puente M,López MG,Martínez-Priego L,D'Auria G,Ruíz-Hueso P,Ferrús-Abad L,de Marco,Galan-Vendrell I,Carbó-Ramirez S,Ruiz-Rodriguez P,Coscollá M,Polackova K,Kramna L,Cinek O,Richter J,Krashias G,Tryfonos C,Bashiardes S,Koptides D,Christodoulou C,Bartolini B,Gruber CE,Di Caro,Castilletti C,Stefani F,Rimoldi SG,Romeri F,Salerno F,Polesello S,Nagy A,Jirincova H,Vecerova J,Novakova L,Cordey S,Murtskhvaladze M,Kotaria N,Schär T,Beisel C,Vugrek O,Rokic F,Trgovec-Greif L,Jurak I,Rukavina T,Sucic N,Schønning K,Karst SM,Kirkegaard RH,Michaelsen TY,Sørensen EA,Knutson S,Brandt J,Le-Quy V,Sørensen T,Petersen C,Pedersen MS,Larsen SL,Skov MN,Rasmussen M,Fonager J,Fomsgaard A,Maksyutov RA,Gavrilova EV,Pyankov OV,Bodnev SA,Tregubchak TV,Shvalov AN,Antonets DV,Resende PC,Goya S,Perrin A,Lee RT,Yadahalli S,Han AX,Russell CA,Schmutz S,Zaheri M,Kufner V,Huber M,Trkola A,Antwerpen M,Walter MC,van der,Gambaro F,Behillil S,Enouf V,Donati F,Ustinova M,Rovite V,Klovins J,Savicka O,Wienecke-Baldacchino AK,Ragimbeau C,Fournier G,Mossong J,Aberle SW,Haukland M,Enkirch T,Advani A,Karlberg ML,Lindsjö OK,Broddesson S,Sláviková M,Licková M,Klempa B,Staronová E,Tichá E,Szemes T,Rusnáková D,Stadler T,Quer J,Anton A,Andres C,Piñana M,Garcia-Cehic D,Pumarola T,Izopet J,Gioula G,Exindari M,Papa A,Chatzidimitriou D,Metallidis S,Pappa S,Macek M,Geryk J,Bro P,Briksí A,Hubácek P,Drevínek P,Zajac M,Kvapil P,Holub M,Kvapilová K,Novotný A,Kaný M,Klempt P,Vapalahti O,Smura T,Sironen T,Selhorst P,Anthony C,Ariën K,Simon-Loriere E,Rabalski L,Bienkowska-Szewczyk K,Borges V,Isidro J,Gomes JP,Guiomar R,Pechirra P,Costa I,Duarte S,Vieira L,Pyrc K,Zuckerman NS,Turdikulova S,Abdullaev A,Dalimova D,Abdurakhimov A,Tagliabracci A,Alessandrini F,Melchionda F,Onofri V,Turchi C,Bagnarelli P,Menzo S,Caucci S,Di Sante,Popa A,Genger JW,Agerer B,Lercher A,Endler L,Smyth M,Penz T,Schuster M,Senekowitsch M,Laine J,Bock C,Bergthaler A,Shevtsov A,Kalendar R,Ramanculov Y,Graf A,Muenchhoff M,Keppler OT,Krebs S,Blum H,Marcello A,Licastro D,D'Agaro P,Laubscher F,Vidanovic D,Tesovic B,Volkening J,Clementi N,Mancini N,Rupnik M,Mahnic A,Walker A,Houwaart T,Wienemann T,Vasconcelos MK,Strelow D,Jensen BO,Senff T,Hülse L,Adams O,Andree M,Hauka S,Feldt T,Keitel V,Kindgen-Milles D,Timm J,Pfeffer K,Dilthey AT,Moore C,Ozdarendeli A,Pavel STI,Yetiskin H,Aydin G,Holyavkin C,Uygut MA,Cevik C,Shchetinin A,Gushchin V,Dinler-Doganay G,Doganay L,Kizilboga-Akgun T,Karacan I,Pancer K,Maes P,Martí-Carreras J,Wawina-Bokalanga T,Vanmechelen B,Thürmer A,Wedde M,Dürrwald R,Von Kleist,Drechsel O,Wolff T,Fuchs S,Kmiecinski R,Michel J,Nitsche A,Casas I,Caballero MI,Zaballos Á,Jiménez P,Jiménez M,Fernández SM,Fernández SV,De La,Fadeev A,Ivanova A,Sergeeva M,Stefanelli P,Torok ME,Hall G,da Silva,Turtle L,Afifi S,Mccluggage K,Beer R,Ledesma J,Maksimovic J,Spellman K,Hamilton WL,Marchbank A,Southgate JA,Underwood A,Taylor B,Yeats C,Abudahab K,Gemmell MR,Eccles R,Lucaci A,Nelson CA,Rainbow L,Whitehead M,Gregory R,Haldenby S,Paterson S,Hughes MA,Curran MD,Baker D,Tucker R,Green LR,Feltwell T,Halstead FD,Wyles M,Jahun AS,Ahmad SSY,Georgana I,Goodfellow I,Yakovleva A,Meredith LW,Gavriil A,Awan AR,Fisher C,Edgeworth J,Lynch J,Moore N,Williams R,Kidd SP,Cortes N,Brunker K,Mccrone JT,Quick J,Duckworth N,Walsh S,Sloan T,Ludden C,George RP,Eltringham G,Brown JR,Aranday-Cortes E,Shepherd JG,Hughes J,Li KK,Williams TC,Johnson N,Jesudason N,Mair D,Thomson E,Shah R,Parr YA,Carmichael S,Robertson DL,Nomikou K,Broos A,Niebel M,Smollett K,Tong L,Miah S,Wittner A,Phillips N,Payne B,Dewar R,Holmes A,Bolt F,Price JR,Mookerjee S,Sethi DK,Potter W,Stanley R,Prakash R,Dervisevic S,Graham JC,Nelson A,Smith D,Young GR,Yew WC,Todd JA,Trebes A,Andersson M,Bull M,Watkins J,Birchley A,Gatica-Wilcox B,Gilbert L,Kumiene-Summerhayes S,Rey S,Chauhan A,Butcher E,Bicknell K,Elliott S,Glaysher S,Lackenby A,Bibby D,Platt S,Mohamed H,Machin NW,Mbisa JL,Evans J,Perry M,Pacchiarini N,Corden S,Adams AG,Gaskin A,Coombs J,Graham LJ,Cottrell S,Morgan M,Gifford L,Kolyva A,Rudder SJ,Trotter AJ,Mather A,Aydin A,Page AJ,Kay GL,de Oliveira,Yasir M,Alikhan NF,Thomson NM,Gilroy R,Kingsley RA,O'Grady J,Gutierrez AV,Diaz M,Le Viet,Tedim AP,Adriaenssens EM,Mcclure CP,Moore C,Sang F,Clark G,Howson-Wells HC,Debebe J,Ball J,Chappell J,Khakh M,Carlile M,Loose M,Lister MM,Holmes N,Tsoleridis T,Fleming VM,Wright V,Smith W,Gallagher MD,Parker M,Partridge DG,Evans C,Baker P,Essex S,Liggett S,Keeley AJ,Bashton M,Rooke S,Dervisevic S,Meader EJ,Balcazar Lopez,Angyal A,Kristiansen M,Tutill HJ,Findlay J,Mestek-Boukhibar L,Forrest L,Dyal P,Williams RJ,Panchbhaya Y,Williams CA,Roy S,Pandey S,Stockton J,Loman NJ,Poplawski R,Nicholls S,Rowe WPM,Khokhar F,Pinckert ML,Hosmillo M,Chaudhry Y,Caller LG,Davidson RK,Griffith L,Rambaut A,Jackson B,Colquhoun R,Hill V,Nichols J,Asamaphan P,Darby A,Jackson KA,Iturriza-Gomara M,Vamos EE,Green A,Aanensen D,Bonsall D,Buck D,Macintyre-Cockett G,de Cesare,Pybus O,Golubchik T,Scarlett G,Loveson KF,Robson SC,Beckett A,Lindsey B,Groves DC,Parsons PJ,Mchugh MP,Barnes JD,Manso CF,Grammatopoulos D,Menger KE,Harrison E,Gunson R,Peacock SJ,Gonzalez G,Carr M,Mihaela L,Popovici O,Brytting M,Bresner C,Fuller W,Workman T,Mentis AF,Kossyvakis A,Karamitros T,Pogka V,Kalliaropoulos A,Horefti E,Kontou A,Martinez-Gonzalez B,Labropoulou V,Voulgari-Kokota A,Evangelidou M,Bizta P,Belimezi M,Lambrechts L,Doymaz MZ,Yazici MK,Cetin NS,Karaaslan E,Kallio-Kokko H,Virtanen J,Suvanto M,Nguyen PT,Ellonen P,Hannula S,Kangas H,Sreenu VB,Burián K,Terhes G,Gombos K,Gyenesei A,Urbán P,Herczeg R,Jakab F,Kemenesi G,Tóth GE,Somogyi B,Zana B,Zeghbib S,Kuczmog A,Földes F,Lanszki Z,Madai M,Papp H,Nagy Á,Pereszlényi CI,Babinszky GC,Dudás G,Csoma E,Abou Tayoun,Alsheikh-Ali AA,Loney T,Nowotny N,Abdul-Wahab O,Gonzalez-Candelas F,Andersen MH,Taylor S. (2020)

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin


View Publication

Parisi A,Le Thi,Mather A,Jombart T,Thanh Tuyen,Phu Huong,Hoang Thu,Carrique-Mas J,Campbell JI,Glass K,Kirk MD,Baker S. (2020)

Differential antimicrobial susceptibility profiles between symptomatic and asymptomatic non-typhoidal Salmonella infections in Vietnamese children.

Epidemiology and infection


View Publication

Related News

Current Vacancies

Applications Close: 23 November 2020

Modelling metabolic capability and phylogeny of host and environmental niche adaptation in E. coli (MATHER_Q21DTP)

The species Escherichia coli is a complex group of organisms which is found in a wide range of vertebrate...

Apply