Dr Alistair Noble

Senior Researcher

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Gut microbes in health and disease




I am the recipient of a Fellowship to work mainly at the Antigen Presentation Research Group at Imperial College London, Northwick Park & St Mark’s Hospital, which has strong collaborative links with the Quadram Institute Bioscience; my fellowship is funded by NHS R&D and I hold an Honorary Senior Lectureship at Imperial College London.

My background is in studies of immune regulation in inflammatory diseases, having previously worked in asthma and allergy research at King’s College London.

I am now applying my experience of immune activity in allergy and asthma to study of immunity in the gut mucosa. I am characterizing T cells and dendritic cells that reside in the colonic tissues of healthy people and comparing them with those from patients with inflammatory bowel disease (IBD). These cells can develop specificity for gut bacteria and my research is investigating this immunity to bacterial populations or their products in the gut in health.

A major aim is not only to understand bacterial immunity in health but also to make comparisons with immunity in IBD or colorectal cancer where bacterial communities in the gut are altered. Studies in mouse models at the Quadram Institute Bioscience will then be based on the human ex vivo studies. Our aim is to develop vaccines or bacterial therapy that could be used to promote health, to treat patients with IBD, or in the prevention/treatment of colorectal cancer.

Key Publications

Noble A, Zhao J. Follicular helper T cells are responsible for IgE responses to Der p 1 following house dust mite sensitization in mice. Clin Exp Allergy 2016; 46:1075-82.

Noble A, Mehta H, Lovell A, Papaioannou E, Fairbanks L. IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8+ T cells. Eur J Immunol 2016; 46:1438-48.

Zhao J, Lloyd CM, Noble A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunology 2013; 6: 335-346.

Leggat JA, Gibbons DL, Haque SFY, Smith AL, Wells JW, Choy K, Lloyd CM, Hayday A, Noble A. Innate Immune Responsiveness of CD8 Memory T Cell Populations Non-specifically Inhibits Allergic Sensitization. J Allergy Clin Immunol 2008; 122:1014-1021.

Wells JW, Cowled CJ, Farzaneh F, Noble A. Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J Immunol 2008; 181:3422-3431.

Durant L., Stentz R., Noble A., Brooks J., Gicheva N., Reddi D., OConnor M., Hoyles L., McCartney A. L., Man R., Tobias Pring E., Dilke S., Hendy P., Segal J., Lim D., Misra R., Hart A. L., Arebi N., Carding S. R., Knight S.. (2020)

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Microbiome, 8, Microbiome volume 8, Article number: 88 (2020)

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Noble A., Durant L., Hoyles L., McCartney A. L., Man R., Segal J., Costello S. P., Hendy P., Reddi D., Bouri S., Lim D. N. F., Pring T., O'Connor M. J., Datt P., Wilson A., Arebi N., Akbar A., Hart A. L., Carding S. R., Knight S. C.. (2019)

Deficient Resident Memory T-Cell and Cd8 T-Cell Response to Commensals in Inflammatory Bowel Disease.

Journal of Crohn's & colitis

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