Dr Ana Victoria Gutiérrez

Research Scientist

Contact via email

Listeria and other invasive pathogens

My first contact with research was while working in the Venezuelan Amazon with Amerindian populations and diagnosis/epidemiology of tuberculosis. During my master I worked on the dynamics of the Pseudomonas aeruginosa biofilm associated with prostheses and surgical surfaces. Then for my PhD, I worked on Mycobacterium abscessus, focusing on two main areas: Molecular mechanisms of drug resistance and cell wall biosynthesis and their impact on virulence using zebrafish as a model of infection. I am currently working on the functional genomics of Listeria to stress associated with the food chain.


Key Publications

Gutiérrez, A. V., Richard, M., Roquet-Banères, F., Viljoen, A., & Kremer, L. (2019). The TetR family transcription factor MAB_2299c regulates the expression of two distinct MmpS-MmpL efflux pumps involved in cross-resistance to clofazimine and bedaquiline in Mycobacterium abscessus. Antimicrobial agents and chemotherapy, 63(10), e01000-19. https://doi.org/10.1128/AAC.01000-19.

Richard, M., Gutiérrez, A. V., Viljoen, A., Rodriguez-Rincon, D., Roquet-Baneres, F., Blaise, M., & Kremer, L. (2019). Mutations in the MAB_2299c TetR regulator confer cross-resistance to clofazimine and bedaquiline in Mycobacterium abscessus. Antimicrobial agents and chemotherapy, 63(1). https://doi.org/10.1128/AAC.01316-18.

Richard, M., Gutiérrez, A. V., & Kremer, L. (2020). Dissecting erm (41)-mediated macrolide-inducible resistance in Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 64(2). DOI: 10.1128/AAC.01879-19

Viljoen, A., Gutiérrez, A. V., Dupont, C., Ghigo, E., & Kremer, L. (2018). A simple and rapid gene disruption strategy in Mycobacterium abscessus: on the design and application of glycopeptidolipid mutants. Frontiers in cellular and infection microbiology, 8, 69. DOI: 10.3389/fcimb.2018.00069

Richard, M., Gutiérrez, A. V., Viljoen, A. J., Ghigo, E., Blaise, M., & Kremer, L. (2018). Mechanistic and structural insights into the unique TetR-dependent regulation of a drug efflux pump in Mycobacterium abscessus. Frontiers in microbiology, 9, 649. DOI: 10.3389/fmicb.2018.00649

Wilkinson E, Giovanetti M, Tegally H, San JE, Lessells R, Cuadros D, Martin DP, Rasmussen DA, Zekri AN, Sangare AK, Ouedraogo AS, Sesay AK, Priscilla A, Kemi AS, Olubusuyi AM, Oluwapelumi AOO, Hammami A, Amuri AA, Sayed A, Ouma AEO, Elargoubi A, Ajayi NA, Victoria AF, Kazeem A, George A, Trotter AJ, Yahaya AA, Keita AK, Diallo A, Kone A, Souissi A, Chtourou A, Gutierrez AV, Page AJ, Vinze A, Iranzadeh A, Lambisia A, Ismail A, Rosemary A, Sylverken A, Femi A, Ibrahimi A, Marycelin B, Oderinde BS, Bolajoko B, Dhaala B, Herring BL, Njanpop-Lafourcade BM, Kleinhans B, McInnis B, Tegomoh B, Brook C, Pratt CB, Scheepers C, Akoua-Koffi CG, Agoti CN, Peyrefitte C, Daubenberger C, Morang'a CM, Nokes DJ, Amoako DG, Bugembe DL, Park D, Baker D, Doolabh D, Ssemwanga D, Tshiabuila D, Bassirou D, Amuzu DSY, Goedhals D, Omuoyo DO, Maruapula D, Foster-Nyarko E, Lusamaki EK, Simulundu E, Ong'era EM, Ngabana EN, Shumba E, El Fahime, Lokilo E, Mukantwari E, Philomena E, Belarbi E, Simon-Loriere E, Anoh EA, Leendertz F, Ajili F, Enoch FO, Wasfi F, Abdelmoula F, Mosha FS, Takawira FT, Derrar F, Bouzid F, Onikepe F, Adeola F, Muyembe FM, Tanser F, Dratibi FA, Mbunsu GK, Thilliez G, Kay GL, Githinji G, van Zyl, Awandare GA, Schubert G, Maphalala GP, Ranaivoson HC, Lemriss H, Anise H, Abe H, Karray HH, Nansumba H, Elgahzaly HA, Gumbo H, Smeti I, Ayed IB, Odia I, Ben Boubaker, Gaaloul I, Gazy I, Mudau I, Ssewanyana I, Konstantinus I, Lekana-Douk JB, Makangara JC, Tamfum JM, Heraud JM, Shaffer JG, Giandhari J, Li J, Yasuda J, Mends JQ, Kiconco J, Morobe JM, Gyapong JO, Okolie JC, Kayiwa JT, Edwards JA, Gyamfi J, Farah J, Nakaseegu J, Ngoi JM, Namulondo J, Andeko JC, Lutwama JJ, O'Grady J, Siddle K, Adeyemi KT, Tumedi KA, Said KM, Hae-Young K, Duedu KO, Belyamani L, Fki-Berrajah L, Singh L, de Oliveira Martins L, Tyers L, Ramuth M, Mastouri M, Aouni M, El Hefnawi, Matsheka MI, Kebabonye M, Diop M, Turki M, Paye M, Nyaga MM, Mareka M, Damaris MM, Mburu MW, Mpina M, Nwando M, Owusu M, Wiley MR, Youtchou MT, Ayekaba MO, Abouelhoda M, Seadawy MG, Khalifa MK, Sekhele M, Ouadghiri M, Diagne MM, Mwenda M, Allam M, Phan MVT, Abid N, Touil N, Rujeni N, Kharrat N, Ismael N, Dia N, Mabunda N, Hsiao NY, Silochi NB, Nsenga N, Gumede N, Mulder N, Ndodo N, Razanajatovo NH, Iguosadolo N, Judith O, Kingsley OC, Sylvanus O, Peter O, Femi O, Idowu O, Testimony O, Chukwuma OE, Ogah OE, Onwuamah CK, Cyril O, Faye O, Tomori O, Ondoa P, Combe P, Semanda P, Oluniyi PE, Arnaldo P, Quashie PK, Dussart P, Bester PA, Mbala PK, Ayivor-Djanie R, Njouom R, Phillips RO, Gorman R, Kingsley RA, Carr RAA, El Kabbaj, Gargouri S, Masmoudi S, Sankhe S, Lawal SB, Kassim S, Trabelsi S, Metha S, Kammoun S, Lemriss S, Agwa SHA, Calvignac-Spencer S, Schaffner SF, Doumbia S, Mandanda SM, Aryeetey S, Ahmed SS, Elhamoumi S, Andriamandimby S, Tope S, Lekana-Douki S, Prosolek S, Ouangraoua S, Mundeke SA, Rudder S, Panji S, Pillay S, Engelbrecht S, Nabadda S, Behillil S, Budiaki SL, van der, Mashe T, Aanniz T, Mohale T, Le Viet T, Schindler T, Anyaneji UJ, Chinedu U, Ramphal U, Jessica U, George U, Fonseca V, Enouf V, Gorova V, Roshdy WH, Ampofo WK, Preiser W, Choga WT, Bediako Y, Naidoo Y, Butera Y, de Laurent, Sall AA, Rebai A, von Gottberg, Kouriba B, Williamson C, Bridges DJ, Chikwe I, Bhiman JN, Mine M, Cotten M, Moyo S, Gaseitsiwe S, Saasa N, Sabeti PC, Kaleebu P, Tebeje YK, Tessema SK, Happi C, Nkengasong J, de Oliveira. (2021)

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.

Science (New York, N.Y.)


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Mashe T, Takawira FT, de Oliveira Martins L, Gudza-Mugabe M, Chirenda J, Munyanyi M, Chaibva BV, Tarupiwa A, Gumbo H, Juru A, Nyagupe C, Ruhanya V, Phiri I, Manangazira P, Goredema A, Danda S, Chabata I, Jonga J, Munharira R, Masunda K, Mukeredzi I, Mangwanya D, Trotter A, Le Viet T, Rudder S, Kay G, Baker D, Thilliez G, Gutierrez AV, O'Grady J, Hove M, Mutapuri-Zinyowera S, Page AJ, Kingsley RA, Mhlanga G. (2021)

Genomic epidemiology and the role of international and regional travel in the SARS-CoV-2 epidemic in Zimbabwe: a retrospective study of routinely collected surveillance data.

The Lancet. Global health


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Snell LB, Fisher CL, Taj U, Stirrup O, Merrick B, Alcolea-Medina A, Charalampous T, Signell AW, Wilson HD, Betancor G, Kia Ik, Cunningham E, Cliff PR, Pickering S, Galao RP, Batra R, Neil SJD, Malim MH, Doores KJ, Douthwaite ST, Nebbia G, Edgeworth JD, Awan AR, Connor TR, Loman NJ, Robson SC, Golubchik T, Estee Torok, Hamilton WL, Bonsall D, Awan AR, Corden S, Goodfellow I, Smith DL, Curran MD, Parmar S, Logistics S, Curation M, Shepherd JG, Parker MD, Aggarwal D, Moore C, Fairley DJ, Loose MW, Watkins J, Bull M, Nicholls S, Aanensen DM, Glaysher S, Bashton M, Pacchiarini N, Underwood AP, de Silva, Wang D, Andersson M, Chauhan AJ, de Cesare, Ludden C, Mahungu TW, Dewar R, McHugh MP, Jesudason NG, Kathy KL, Shah RN, Taha Y, Templeton KE, Cottrell S, O'Grady J, Rambaut A, Smith CP, Holden MTG, Thomson EC, Moses S, Chand M, Constantinidou C, Darby AC, Hiscox JA, Paterson S, Unnikrishnan M, Page AJ, Volz EM, Houldcroft CJ, Jahun AS, McKenna JP, Meredith LW, Nelson A, Pandey S, Young GR, Price A, Re S, Roy S, Temperton B, Wyles M, Rooke S, Shaaban S, Adams H, Bourgeois Y, Loveson KF, O'Toole Á, Stark R, Harrison EM, Heyburn D, Peacock SJ, Buck D, John M, Jamrozy D, Quick J, Batra R, Bellis KL, Blane B, Girgis ST, Green A, Justice A, Kristiansen M, Williams RJ, Poplawski R, Scarlett GP, Todd JA, Fraser C, Breuer J, Castellano S, Michell SL, Gramatopoulos D, Edgeworth J, Kay GL, da Silva, Jeffries AR, Ott S, Pybus O, Robertson DL, Simpson DA, Williams C, Auckland C, Boyes J, Dervisevic S, Ellard S, Goncalves S, Meader EJ, Muir P, Osman H, Prakash R, Sivaprakasam V, Vipond IB, Masoli JA, Alikhan NF, Carlile M, Craine N, Haldenby ST, Holmes N, Lyons RA, Moore C, Perry M, Warne B, Williams T, Berry L, Bosworth A, Brown JR, Campbell S, Casey A, Clark G, Collins J, Cox A, Davis T, Eltringham G, Evans C, Graham C, Halstead F, Harris KA, Holmes C, Hutchings S, Iturriza-Gomara M, Johnson K, Jones K, Keeley AJ, Knight BA, Koshy C, Liggett S, Lowe H, Lucaci AO, Lynch J, McClure PC, Moore N, Mori M, Partridge DG, Madona P, Pymont HM, Randell PA, Raza M, Ryan F, Shaw R, Sloan TJ, Swindells E, Adams A, Asad H, Birchley A, Brooks TT, Bucca G, Butcher E, Caddy SL, Caller LG, Chaudhry Y, Coombes J, Cronin M, Dyal PL, Evans JM, Fina L, Gatica-Wilcox B, Georgana I, Gilbert L, Graham L, Groves DC, Hall G, Hilvers E, Hosmillo M, Jones H, Jones S, Khokhar FA, Kumziene-Summerhayes S, MacIntyre-Cockett G, Martinez Nunez, McKerr C, McMurray C, Myers R, Panchbhaya YN, Pinckert ML, Plimmer A, Stockton J, Taylor S, Thornton A, Trebes A, Trotter AJ, Tutill HJ, Williams CA, Yakovleva A, Yew WC, Alam MT, Baxter L, Boyd O, Nascimento FF, Freeman TM, Geidelberg L, Hughes J, Jorgensen D, Lindsey BB, Orton RJ, Ragonnet-Cronin M, Southgate J, Vattipally S, Starinskij I, Singer JB, Abudahab K, de Oliveira, Le-Viet T, Menegazzo M, Taylor Meng, Yeats CA, Palmer S, Churcher CM, Davies A, De Lacy, Downing F, Edwards S, Smith N, Coll F, Hadjirin NF, Bolt F, Alderton A, Berriman M, Charles IG, Cortes N, Curran T, Danesh J, Eldirdiri S, Elumogo N, Hattersley A, Holmes A, Howe R, Jones R, Kenyon A, Kingsley RA, Kwiatkowski D, Langford C, Mason J, Mather AE, Meadows L, Morgan S, Price J, Robinson TI, Shankar G, Wain J, Webber MA, Bradley DT, Chapman MR, Crooke D, Eyre D, Guest M, Gulliver H, Hoosdally S, Kitchen C, Merrick I, Mookerjee S, Munn R, Peto T, Potter W, Sethi DK, Smith W, Snell LB, Stanley R, Stuart C, Wastenge E, Acheson E, Afifi S, Allara E, Amato R, Angyal A, Aranday-Cortes E, Ariani C, Ashworth J, Attwood S, Aydin A, Baker DJ, Balcazar CE, Beckett A, Beer R, Betancor G, Betteridge E, Bibby D, Bradshaw D, Bresner C, Bridgewater HE, Broos A, Brown R, Brown PE, Brunker K, Carmichael SN, Cheng JKJ, Colquhoun R, Dabrera G, Debebe J, Drury E, du Plessis, Eccles R, Ellaby N, Farbos A, Farr B, Findlay J, Fisher CL, Forrest LM, Francois S, Frost LR, Fuller W, Gallagher E, Gallagher MD, Gemmell M, Gilroy RA, Goodwin S, Green LR, Gregory R, Groves N, Harrison JW, Hartman H, Hesketh AR, Hill V, Hubb J, Hughes M, Jackson DK, Jackson B, James K, Johnson N, Johnston I, Keatley JP, Kraemer M, Lackenby A, Lawniczak M, Lee D, Livett R, Lo S, Mair D, Maksimovic J, Manesis N, Manley R, Manso C, Marchbank A, Martincorena I, Mbisa T, McCluggage K, McCrone JT, Miah S, Michelsen ML, Morgan M, Nebbia G, Nelson C, Nichols J, Niola P, Nomikou K, Palmer S, Park N, Parr YA, Parsons PJ, Patel V, Patel M, Pearson C, Platt S, Puethe C, Quail M, Raghwani J, Rainbow L, Rajatileka S, Ramsay M, Resende Silva, Rudder S, Ruis C, Sambles CM, Sang F, Schaefer U, Scher E, Scott C, Shirley L, Signell AW, Sillitoe J, Smith C, Smollett KL, Spellman K, Stanton TD, Studholme DJ, Taylor-Joyce G, Tedim AP, Thompson T, Thomson NM, Thurston S, Tong L, Tonkin-Hill G, Tucker RM, Vamos EE, Vasylyeva T, Warwick-Dugdale J, Weldon D, Whitehead M, Williams D, Williamson KA, Wilson HD, Workman T, Yasir M, Yu X, Zarebski A, Evelien M, Ahmad SSY, Alcolea-Medina A, Allan J, Asamaphan P, Atkinson L, Baker P, Ball J, Barton E, Beale MA, Beaver C, Beggs A, Bell A, Berger DJ, Berry L, Bewshea CM, Bicknell K, Bird P, Bishop C, Boswell T, Breen C, Buddenborg SK, Burton-Fanning S, Chalker V, Chappell JG, Charalampous T, Cormie C, Cortes N, Coupland LJ, Cowell A, Davidson RK, Dias J, Diaz M, Dibling T, Dorman MJ, Duckworth N, Elliott S, Essex S, Fallon K, Feltwell T, Fleming VM, Forrest S, Foulser L, Garcia-Casado MV, Gavriil A, George RP, Gifford L, Gill HK, Greenaway J, Griffith L, Gutierrez AV, Hale AD, Haque T, Harper KL, Harrison I, Heaney J, Helmer T, Higginson EE, Hopes R, Howson-Wells HC, Hunter AD, Impey R, Irish-Tavares D, Jackson DA, Jackson KA, Joseph A, Kane L, Kay S, Kermack LM, Khakh M, Kidd SP, Kolyva A, Lee JC, Letchford L, Levene N, Levett L, Lister MM, Lloyd A, Loh J, Macfarlane-Smith LR, Machin NW, Maes M, McGuigan S, McMinn L, Mestek-Boukhibar L, Molnar Z, Monaghan L, Moore C, Naydenova P, Neaverson AS, Nelson R, Niebel MO, O'Toole E, Padgett D, Patel G, Payne BA, Prestwood L, Raviprakash V, Reynolds N, Richter A, Robinson E, Rogers HA, Rowan A, Scott G, Shah D, Sheriff N, Sluga G, Souster E, Spencer-Chapman M, Sridhar S, Swingler T, Tang J, Taylor GP, Tsoleridis T, Turtle L, Walsh S, Wantoch M, Watts J, Waugh S, Weeks S, Williams R, Willingham I, Wise EL, Wright V, Wyllie S, Young J, Amy Gaskin, Rowe W, Siveroni I, Johnson R. (2021)

Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 infection early in the pandemic and the role of unidentified cases in transmission.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases


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Page AJ, Mather AE, Le Viet T, Meader EJ, Alikhan NF, Kay GL, de Oliveira Martins L, Aydin A, Baker DJ, Trotter AJ, Rudder S, Tedim AP, Kolyva A, Stanley R, Yasir M, Diaz M, Potter W, Stuart C, Meadows L, Bell A, Gutierrez AV, Thomson NM, Adriaenssens EM, Swingler T, Gilroy RAJ, Griffith L, Sethi DK, Aggarwal D, Brown CS, Davidson RK, Kingsley RA, Bedford L, Coupland LJ, Charles IG, Elumogo N, Wain J, Prakash R, Webber MA, Smith SJL, Chand M, Dervisevic S, O'Grady J. (2021)

Large-scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management.

Microbial genomics


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