Andrew Bell

Postgraduate Student

Contact via email

Glycobiology of host-microbe interactions in the gut

My PhD project focuses on the impact of bacterial sialic acid metabolism on gut homeostasis. In particular I am interested in how a novel bacterial mechanism of utilising mucin-derived sialic acid may provide a competitive advantage to bacteria expressing an intramolecular trans-sialidases, and help to protect the gut from pathogens.

I studied Biochemistry at the University of East Anglia, and as part of the degree programme undertook a year in Industry placement in Dr Claire Domoney’s lab at the John Innes Centre where I was involved in a project to increase understanding of chlorophyll degradation and turnover pathways in plants.

I returned to Dr Domoney’s lab after completing my undergraduate where I continued the same research theme and discovered that the SGRL protein can regulate chlorophyll metabolism contributing to plant growth and development in pea.

Bell A,Severi E,Lee MO,Monaco S,Latousakis D,Angulo J,Thomas GH,Naismith J,Juge N. (2020)

Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria.

The Journal of biological chemistry

View Publication

Bell A., Brunt J., Crost E., Vaux L., Nepravishta R., Owen C. D., Latousakis D., Xiao A., Li W., Chen X., Walsh M. A., Claesen J., Angulo J., Thomas G. H., Juge N.. (2019)

Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut.

Nature microbiology, 4, 2393-2404

View Publication

Monestier M., Latousakis D., Bell A., Tribolo S., Tailford L. E., Colquhoun I. J., Le Gall G., Yu H., Chen X., Rejzek M., Dedola S., Field R. A., Juge N.. (2017)

Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives.

Carbohydrate Research, 451, 110-117

View Publication

Owen C. D., Tailford L. E., Monaco S., Suligoj T., Vaux L., Khedri Z., Yu H., Lecointe K., Walshaw J., Tribolo S., Horrex M., Bell A., Chen X., Taylor G. L., Varki A., Angulo J., Juge N.. (2017)

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus.

Nature communications, 8, 2196

View Publication

Related News