Dr Andy Goldson

Researcher

Contact via email

Core Science Resources - methods development and innovation

Links/websites:

I presently work in the area of Molecular Microbiology identifying microbial contamination events.

Previous research:

  • Investigating the role of immune cells in the regulation and maintenance of gut homeostasis.
  • Life style intervention to control the progression to Type II Diabetes
  • Effects of isothiocyanates on respiratory inflammation
  • Single-cell gene expression in genetic variability
  • The role of the MAP kinase pathway in the formation of colon cancer
  • Identification of genetic biomarkers of selenium status in human intervention studies
  • Elucidation of the role of selenium in the formation of prostate cancer
  • Isolation and purification of xylanase inhibitor proteins
  • Identification of novel ferulic acid esterases for application in industrial processes
  • Use of molecular markers in the study of gene flow and speciation in the marine environment
  • Phenotypic plasticity in the life history traits of arthropods

Key Publications

Wills, Q.F., Livak, K.J., Tipping, A.J., Enver, T., Goldson, A.J., Sexton, D.S. & Holmes, C.C. (2013) Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments. Nature Biotechnology Vol. 31: 748-752.

Livak, K.J., Wills, Q.F., Tipping, A.J., Datta, K., Mittal, R., Goldson, A.J., Sexton, D.S. & Holmes, C.C. (2013) Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells. Methods Vol. 59:71-79.

Goldson, A. J., Fairweather-Tait, S.J., Armah, C.N., Bao, Y., Broadley, M.R., Dainty, J.R., Hart, D.J., Teucher, B., & Hurst, R. (2011). Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: randomised double-blind placebo controlled trial. PLoS ONE Vol. 6(3)

Hurst, R., Armah, C.N., Dainty, J.R., Hart, D.J., Teucher, B., Goldson, A.J., Broadley, M.R., Motley, A.K. & Fairweather-Tait, S.J. (2010) Establishing optimal selenium status results of a randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition Vol. 91: 923-931.

Hurst, R., Elliott, R.M., Goldson, A.J. & Fairweather-Tait, S.J. (2008) Se-methylselenocysteine alters collagen gene and protein expression in human prostate cells. Cancer Letters Vol. 269: 117-126

Hurst R., Armah C. N., Dainty J. R., Hart D. J., Teucher B., Goldson A. J., Broadley M. R., Motley A. K., Fairweather-Tait S. J.. (2010)

Establishing optimal selenium status: results of a randomised, double-blind, placebo-controlled trial

American Journal of Clinical Nutrition, 91, 923-931


Hurst R., Elliott R. M., Goldson A., Fairweather-Tait S. J.. (2008)

Se-methylselenocysteine alters collagen gene and protein expression in human prostate cells

Cancer Letters, 269, 117-126


View Publication

Furniss C., Goldson A. J., Alliwan F., Chanliaud E., Juge N.. (2006)

Quantification of xylanase inhibitors by immunodetection: the way forward?

Journal of the Science of Food and Agriculture, 86, 1737-1740


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JakubikovaJ., Sedlak J., Bacon J. R., Goldson A. J., Bao Y. P.. (2005)

Effects of MEK1 and PI3K inhibitors on allyl-, benzyl- and phenylethyl-isothiocyanate-induced G2/M arrest and cell death in Caco-2 cells

International Journal of Oncology, 27, 1449-1458


Bonnin E., Daviet S., Gebruers K., Delcour J. A., Goldson A. J., Juge N., Saulnier L.. (2005)

Variation in the levels of the different xylanase inhibitors in grain and flour of 20 French wheat cultivars

Journal of Cereal Science, 41, 375-379


View Publication

Garcia-Conesa M. T., Crepin V., Goldson A. J., Williamson G., Cummings N. J., Connerton I. F., Faulds C. B., Kroon P. A.. (2004)

The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, TsFaeC, with a broad substrate specificity

Journal of Biotechnology, 108, 227-241


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