Dr Andy Goldson

Researcher

Contact via email

Core Science Resources - methods development and innovation

Links/websites:

I presently work in the area of Molecular Microbiology identifying microbial contamination events.

Previous research:

  • Investigating the role of immune cells in the regulation and maintenance of gut homeostasis.
  • Life style intervention to control the progression to Type II Diabetes
  • Effects of isothiocyanates on respiratory inflammation
  • Single-cell gene expression in genetic variability
  • The role of the MAP kinase pathway in the formation of colon cancer
  • Identification of genetic biomarkers of selenium status in human intervention studies
  • Elucidation of the role of selenium in the formation of prostate cancer
  • Isolation and purification of xylanase inhibitor proteins
  • Identification of novel ferulic acid esterases for application in industrial processes
  • Use of molecular markers in the study of gene flow and speciation in the marine environment
  • Phenotypic plasticity in the life history traits of arthropods

Key Publications

Wills, Q.F., Livak, K.J., Tipping, A.J., Enver, T., Goldson, A.J., Sexton, D.S. & Holmes, C.C. (2013) Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments. Nature Biotechnology Vol. 31: 748-752.

Livak, K.J., Wills, Q.F., Tipping, A.J., Datta, K., Mittal, R., Goldson, A.J., Sexton, D.S. & Holmes, C.C. (2013) Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells. Methods Vol. 59:71-79.

Goldson, A. J., Fairweather-Tait, S.J., Armah, C.N., Bao, Y., Broadley, M.R., Dainty, J.R., Hart, D.J., Teucher, B., & Hurst, R. (2011). Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: randomised double-blind placebo controlled trial. PLoS ONE Vol. 6(3)

Hurst, R., Armah, C.N., Dainty, J.R., Hart, D.J., Teucher, B., Goldson, A.J., Broadley, M.R., Motley, A.K. & Fairweather-Tait, S.J. (2010) Establishing optimal selenium status results of a randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition Vol. 91: 923-931.

Hurst, R., Elliott, R.M., Goldson, A.J. & Fairweather-Tait, S.J. (2008) Se-methylselenocysteine alters collagen gene and protein expression in human prostate cells. Cancer Letters Vol. 269: 117-126

 

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