Anna Isaacs

Postgraduate Student

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Mechanisms regulating the gut-liver axis during health and disease

I am a BBSRC funded DTP student in Dr Naiara Beraza’s group. The title of my project is “Metabolic regulation of inflammation; how energy controls immunity”.

In 2012, I graduated from the University of Leicester with a 2.1 Honours degree in Medical Biochemistry. Then, I undertook a laboratory placement at the Wolfson Centre of Neuromuscular disease. From January 2013 to September 2017 I held a Research Assistant position at the University of Cambridge, Department of Haematology. From October 2014 to October 2015 I had an opportunity to undertake an MPhil project alongside my employment.

During my Masters investigation I developed a passion for immune cell metabolism and therefore I am excited to be a part of Dr Beraza’s group, where I am investigating the metabolic reprogramming of macrophages that occurs during liver and gut disease. Our work may have the potential to therapeutically modulate inflammation, therefore prevent gut and liver disease and preserve health.

Isaacs A., Echeandia M., Moreno-Gonzalez M., Brion A., Goldson A., Philo M., Patterson A. M., Parker A., Galduroz M., Baker D., Rushbrook S. M., Hildebrand F., Beraza N.. (2020)

Intestinal microbiome-macrophage crosstalk contributes to cholestatic liver disease by promoting intestinal permeability.

Hepatology (Baltimore, Md.)

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Blokker B. A., Maijo M., Echeandia M., Galduroz M., Patterson A. M., Ten A., Philo M., Schungel R., Gutierrez-de Juan V., Halilbasic E., Fuchs C., Le Gall G., Milkiewicz M., Milkiewicz P., Banales J. M., Rushbrook S. M., Mato J. M., Trauner M., Müller M., Martínez-Chantar M. L., Varela-Rey M., Beraza N.. (2018)

Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease.

Hepatology (Baltimore, Md.)

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