Bhavika Parmanand

Postgraduate Student

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Translational microbiome

Many exogenous factors affect the gut microbiome and it has long been known that diet is a major contributing factor. Iron-fortified foods and iron supplements are widely consumed but most of the iron is not absorbed into the body but passes through to the colon where potentially pathogenic bacteria are able to utilize it for growth.

The effects of the supplemental iron on the gut environment have not yet been fully elucidated so my research aims to combine metabolomics and high throughput metagenomics with an in vitro colon model system to characterise the relationship between the human gut microbiome and iron. Secondly, I  will determine if a colonic delivery system (containing iron-binding compounds) prevent the utilisation of iron by potentially pathogenic bacteria in order to test the hypothesis that the growth of beneficial bacteria, such as Lactobacilli, is facilitated when the numbers of pathogenic bacteria are reduced.

Parmanand B., Kellingray L., Le Gall G., Basit A., Fairweather S., Narbad A.. (2019)

A decrease in iron availability to human gut microbiome reduces the growth ofpotentially pathogenic gut bacteria; an in vitro colonic fermentation study

Journal of Nutritional Biochemistry, 67, 20-27

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