My research combines bioinformatics and experimental microbiology to address the challenge of antimicrobial resistance.

In 2020, I started a PhD in Dr Gemma Langridge’s group at Quadram investigating how E. coli responds to trimethoprim challenge to inform rapid point-of-care susceptibility testing for urinary tract infections. This work combined genome-scale metabolic modelling, high-throughput time-course viability assays, and microbial genomics to generate mathematical models of trimethoprim’s mode of action.

In 2024, I joined Prof Alison Mather’s group as a postdoctoral researcher investigating if and how soil microbial ecosystems recover from pro-longed exposure to antibiotics. Here, I am using metagenomics to build mathematical models of microbial ecosystems changing over time and predict future outcomes.

Key publications

Cailean Carter, Alexandra Hutchison, Steven Rudder, Elizabeth Trotter, Emma V Waters, Ngozi Elumogo, Gemma C Langridge. Uropathogenic Escherichia coli population structure and antimicrobial susceptibility in Norfolk, UK,  Journal of Antimicrobial Chemotherapy, dkad201, DOI: 10.1093/jac/dkad201