Dr Carmen Pin

Research Leader

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I studied Veterinary Medicine and completed my PhD studies in Food Microbiology at the University Complutense of Madrid in the 90s. After a two-year postdoctoral stay on Predictive Microbiology at the Institute of Food Research in Reading, I returned to Madrid where I worked as a project scientist at the Faculty of Veterinary while completing a bachelor and a master degree in Statistics for which I received the best student award from HRH Princess Cristina of Spain.

In 2002, I was recruited by the Institute of Food Research in Norwich to enhance the institute’s interdisciplinary science. I joined the group of Prof. József Baranyi, an international leader team in Predictive Microbiology and founder of the ComBase database. My work focused on quantifying the microbial response, at the population, single cell and, molecular level, to environmental stimuli throughout the food chain to ensure the production of microbiologically safe foods.

With time, my interest evolved towards the development of multi-scale models able to quantify the intrinsic spatiotemporal patterns that give rise to the collective functionality of multiple organic systems and the microbiota in a healthy gut. Since 2013, I have led a multidisciplinary group of modelers and biologists targeting the integration of experimental and theoretical approaches to study gut biology.

I have co-authored some 75 peer-reviewed scientific papers and I am a member of the editorial board of the Applied and Environmental Microbiology journal.

Key Publications

Pin C, and Baranyi, J. (2008) Single cell and population lag time as a function of the age of the cells. Applied and Environmental Microbiology. 74, 2534-2536.

Pin C. Watson, A.J.M. and Carding, S.R. (2012) Modelling the spatio-temporal cell dynamics reveals novel insights on cell differentiation and proliferation in the small intestinal crypt. PLOS ONE. 7(5): e37115.

Avendaño-Pérez G. and Pin C. (2013). Loss of culturability of Salmonella enterica subsp. enterica Serovar Typhimurium upon cell-cell contact with human faecal bacteria. Applied and Environmental Microbiology. 79(10):3257-63.

Pin C., Parker A., Gunning A.P., Ohta Y., Johnson I.T., Carding S.R., and Sato T. (2015). An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. Integrative Biology. 7: 213-228.

Leushacke M., Barker N.*, Pin C.* (2016). Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium. Scientific Reports. 6, 21923. (* equal contribution)

Lasrado R., Boesmans W., Kleinjung J., Pin C., Bell D., Bhaw L., McCallum S., Zong H., Luo L., Clevers H., Vanden Berghe P., Pachnis V.. (2017)

Lineage-dependent Spatial and Functional Organization of the Mammalian Enteric Nervous System

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Parker A., Maclaren O., Fletcher A. G., Muraro D., Kreuzaler P. A., Byrne H. M., Maini P. K., Watson A. J. M., Pin C.. (2017)

Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi

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Maclaren O. J., Parker A., Pin C., Carding S. R., Watson A. J. M., Fletcher A. G., Byrne H., Maini P. K.. (2017)

A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.

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Avendano-Perez G., Nueno C., Narbad A., George S., Baranyi J., Pin C.. (2015)

Interactions of Salmonella enterica subspecies enterica serovar. Typhimurium with gut bacteria

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Related News

Insights into the development of our second brain

Glial cells (pink) at the bottom of a crypt in the gut lining. Image by Aimee Parker

Contact killing of Salmonella Typhimurium by human faecal bacteria

awaiting image