Cristina Alcon

Postgraduate Student

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Early life microbiota-host interactions

My PhD work in Lindsay’s lab is focused on understanding the impact that antibiotics have on the preterm life gut microbiota. Antibiotics are the most frequently used drugs in neonatal intensive care units (NICUs). Between 75% and 94% of neonate babies are exposed to antibiotics during their stay in a NICU. More research is needed to understand the impact of antibiotics on the gut bacteria which plays a key role in assuring good health to the infant.

My science journey began some time ago in 2003 when I completed my undergraduate degree in Biochemistry in Valencia (Spain). Later on, I worked as a Research Assistant in several research laboratories in the UK, Spain and France which gave me a broad skill base in laboratory techniques. In 2013 I started working for Lindsay to help set up a probiotic trial in collaboration with Dr Paul Clarke and the NICU of the Norfolk and Norwich University Hospital. I immediately developed a passion to work in the field of clinical microbiology, and two years later, I started a PhD in Lindsay´s research team.

Hughes K. R., Schofield Z., Dalby M. J., Caim S., Chalklen L., Bernuzzi F., Alcon C., Le Gall G., Watson A. J. M., Hall L. J.. (2020)

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding.

FASEB Journal

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Chen Y., Brook T. C., Soe C. Z., O'Neill I., Alcon C., Leelastwattanagul O., Phillips S., Caim S., Clarke P., Hall L. J., Hoyles L.. (2020)

Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.

Microbial genomics

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Alcon C,Dalby MJ,Caim S,Ketskemety J,Shaw A,Sim K,Lawson MAE,Kiu R,Leclaire C,Chalklen L,Kujawska M,Mitra S,Fardus-Reid F,Belteki G,McColl K,Swann JR,Kroll JS,Clarke P,Hall LJ. (2020)

Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study.

Cell reports. Medicine

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Rowe W. P., Carrieri A. P., Alcon C., Caim S., Shaw A., Sim K., Kroll J. S., Hall L. J., Pyzer-Knapp E. O., Winn M. D.. (2019)

Streaming histogram sketching for rapid microbiome analytics.

Microbiome, 7, 40

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Chen Y., Brook T. C., Alcon C., Clarke P., Hall L. J., Hoyles L.. (2019)

Draft Genome Sequence of Raoultella ornithinolytica P079F W, Isolated from the Feces of a Preterm Infant.

Microbiology resource announcements, 8

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Chen Y., Brook T. C., Alcon C., Clarke P., Hall L. J., Hoyles L.. (2019)

Draft Genome Sequences of Citrobacter freundii and Citrobacter murliniae Strains Isolated from the Feces of Preterm Infants.

Microbiology resource announcements, 8

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Leggett R. M., Alcon-Giner C., Heavens D., Caim S., Brook T. C., Kujawska M., Martin S., Peel N., Acford-Palmer H., Hoyles L., Clarke P., Hall L. J., Clark M. D.. (2019)

Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens.

Nature microbiology

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Scott N. A., Andrusaite A., Andersen P., Lawson M., Alcon C., Leclaire C., Caim S., Le Gall G., Shaw T., Connolly J. P. R., Roe A. J., Wessel H., Bravo-Blas A., Thomson C. A., Kästele V., Wang P., Peterson D. A., Bancroft A., Li X., Grencis R., Mowat A. M., Hall L. J., Travis M. A., Milling S. W. F., Mann E. R.. (2018)

Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis.

Science translational medicine, 10

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