Dr Didier Ndeh

Researcher

Contact via email

Glycobiology of host-microbe interactions in the gut

Links/websites:

ORCID

I completed my PhD at Newcastle University in 2013. Prior to this, I obtained a Masters in Biotechnology at Nottingham Trent University in 2009 and a BSc in Biochemistry from the University of Buea in Cameroon, in 2007.

After completing my PhD, I was employed as a Postdoctoral Research Associate at Newcastle University in the group of Professor Harry Gilbert.  Currently, I am a Postdoctoral Scientist at the Quadram Institute in the group of Professor Nathalie Juge.

My general research theme is the understanding of host-microbial interactions involving the human gut microbiota (HGM). My focus is on the mechanisms of complex glycan metabolism by the HGM. I work with model organisms from the gut phyla Bacteroidetes and Firmicutes which are dominant members of the HGM.

Key Publications

Ndeh DA*, Rogowski A, Cartmell A, Luis AS, Basle A, Gray J, Venditto I, Briggs J, Yang X, Labourel A, Terrapon N, Buffetto F, Nepogodiev S, Xiao Y, Field RA, Zhu Y, ONeill MA, Urbanowicz BR, York WS, Davies GJ, Abbott DW, Ralet MC, Martens EC, Henrissat B, Gilbert HJ. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. https://doi.org/10.1038/nature21725, Nature, 2017

Luis AS, Briggs J, Zhang X, Farnell B, Ndeh DA, Labourel A, Baslé A, Cartmell A, Terrapon N, Stott K, Lowe EC, McLean R, Shearer K, Schückel J, Venditto I, Ralet M, Henrissat B, Martens EC, Mosimann SC, Abbott DW, Gilbert HJ. Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. https://doi.org/10.1038/s41564-017-0079-1, Nature Microbiology, 2017.

Ndeh DA*, Gilbert HJ. Biochemistry of Complex Glycan Depolymerisation by the Human Gut Microbiota.  https://doi.org/10.1093/femsre/fuy002, FEMS Microbiol Rev., 2018.

Cartmell A, Muñoz-Muñoz J, Briggs JA, Ndeh DA*, Lowe EC, Baslé A, Terrapon N, Stott K, Heunis T, Gray J, Yu L, Dupree P, Fernandes PZ, Shah S, Williams SJ, Labourel A, Trost M, Henrissat B, Gilbert HJ. A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. https://doi.org/10.1038/s41564-018-0258-8, Nature Microbiology, 2018.

Ndeh DA*, Muñoz-Muñoz J, Cartmell A, Bulmer D, Wills C,  Henrissat B,  and Gray J, The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan degrading polysaccharide lyase family PL29. https://doi.org/10.1074/jbc.RA118.004510, Journal of Biological Chemistry, 2018.