I am a post-doctoral research scientist in Prof. Nathalie Juge’s Group investigating the role of gut microbiota in promoting colorectal cancer. Alongside my research, I also manage the QIB Flow Cytometry Facility on a part-time basis.

In my current project, I am focused on unravelling the mechanisms behind the interaction between gut bacteria polysaccharides and lectins expressed in the host immune cells.

During my PhD in the Juge Group, I discovered a novel interaction between F. nucleatum ssp. and the Siglec-7 lectin. This was followed by a joint post-doctoral position in Prof. Lara Mahal and Prof. Matthew Macauley’s Lab at University of Alberta in Canada, on the role of Siglecs and mammalian extracellular vesicle interaction in immune response.

I’m passionate about uncovering the complex interplay between CRC microbiota and host cell interactions, and I’m driven to contribute to the growing knowledge in this field.

Key Publications

Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, Elena Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley. ”Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket”. Nature Communications, 2023, Apr 14, 2327

Dimitra Lamprinaki, Pilar Garcia-Vello, Roberta Marchetti, Charlotte Hellmich, Kelli A. McCord, Kristian M. Bowles, Matthew S. Macauley, Alba Silipo, Cristina De Castro, Paul R. Crocker and Nathalie Juge. ”Siglec-7 Mediates Immunomodulation by Colorectal Cancer-Associated Fusobacterium nucleatum ssp. animalis”. Frontiers in Immunology, 2021, Oct 1;12:744184

Pilar Garcia-Vello, Flaviana Di Lorenzo, Dimitra Lamprinaki, Anna Notaro, Immacolata Speciale, Antonio Molinaro, Nathalie Juge, and Cristina De Castro.
‘’Structure of the O-Antigen and the Lipid A from the Lipopolysaccharide of Fusobacterium nucleatum ATCC 51191’’. ChemBioChem, 2020, Apr 6;22(7):1252-1260

Dimitra Lamprinaki, Gemma Beasy, Aleksandra Zhekova, Alexandra Wittmann, Steve James, Jo Dicks, Yoichiro Iwakura, Shinobu Saijo, Xiaomin Wang, Chung-Wai Chow, Ian Roberts, Tamas Korcsmaros, Ulrike Mayer, Thomas Wileman and Norihito Kawasaki. “LC3 associated phagocytosis is required for dendritic cell inflammatory cytokine response to gut commensal yeast Saccharomyces Cerevisiae”. Frontiers in Immunology, 2017, Oct 25;8:1397.

Alexandra Wittmann, Dimitra Lamprinaki, Kristian M Bowles, Ewa Katzenellenbogen, Yuriy A Knirel, Takashi Nishimura, Naoki Matsumoto, Kazuo Yamamoto, Yoichiro Iwakura, Shinobu Saijo, and Norihito Kawasaki. “Dectin-2 Recognizes an O-Antigen Polysaccharide from a Human Opportunistic Pathogen and Augments Lipopolysaccharide Activation of Myeloid Cells”. Journal of Biological Chemistry, 2016, Aug 19;291(34):17629-38.