Dr Eleftheria Trampari


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Investigating the evolution of antimicrobial resistance

As a scientist, I am fascinated by the molecular mechanisms underpinning bacterial behaviour during infection and this is where my research has focused to date. Having recently joined the Webber group, my aim is to apply my knowledge background and contribute to the raising issue of antimicrobial resistance.

Prior to joining the Quadram institute Bioscience, I worked as a postdoctoral researcher, at the John Innes Centre, in Professor Barrie Wilkinson’s lab, where I focused on the investigation of the role and function of macrophage infectivity potentiator-like virulence factors in Pseudomonas aeruginosa.

During my PhD in Dr Jacob Malone’s lab, I focused on the identification and characterisation of novel binding targets of the behavioural regulator cyclic-di-GMP in Pseudomonas sp. By using a combination of genetic manipulation and protein biochemistry techniques, I succeeded in establishing a direct link between a key component of the bacterial type III secretion system and cyclic di-GMP, which has profound implications for our understanding of bacterial virulence and movement.

Holding a PhD in Molecular Microbiology and Biochemistry, and two MSc degrees, in Biotechnology and Molecular Ecology, I have extensive expertise in molecular biology, genetics and protein biochemistry. My specific skills range from the genetic manipulation and analysis of gram-negative bacterial species to cutting edge biochemical techniques and phenotypic analysis of bacterial populations.

Key Publications

Trampari, C.E.M. Stevenson, R.H. Little, T. Wilhelm, D.M. Lawson and J.G. Malone, Bacterial Rotary Export ATPases are Allosterically Regulated by the Nucleotide Second Messenger Cyclic-di-GMP Trampari, C.E.M. Stevenson, R.H. Little, T. Wilhelm, D.M. Lawson and J.G. Malone, J Biol. Chem. (2015) 290 (40), 24470-24483

Dorota Skotnicka, Gregory T. Smaldone, Tobias Petters, Eleftheria Trampari, Jennifer Liang, Volkhard Kaever, Jacob G. Malone, Mitchell Singer & Lotte Søgaard-Andersen  A minimal threshold of c-di-GMP is essential for fruiting body formation and sporulation in Myxococcus xanthus  PLoS Genet (2016) 12(5): e1006080.

R.H. Little, L. Grenga, G. Saalbach, A.M. Howat, S. Pfeilmeier, E. Trampari and J.G. Malone  Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation



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