My research interests focus on narrowing the gaps between scientific disciplines (chemistry, biology, physics, medicine, etc) to develop innovative methods that tackle the big modern scientific challenges. Following my chemistry undergraduate, I undertook a biochemistry/photochemistry PhD at the University of East Anglia (UEA) where I developed methods for producing photosensitiser-proteoliposome systems to study light driven transmembrane electron transfers via a porin:cytochrome protein complex. Following this I worked on heme enhancement systems for overexpression within cytochromes in E. coli.
I joined the Norwich Medical School at UEA in early 2017 to help generate transposon libraries of non-aureus staphylococci for transposon-directed insertion sequencing (TraDIS). These libraries, used with developed biofilm models, have helped to identify essential genes required for biofilm formation that lead to prosthetic joint infections. I have developed this biofilm model to investigate the essential genes required for initial biofilm formation of P. aeruginosa. Since early 2018 I have also been investigating the application of bacteriophage technology to treat staphylococcal prosthetic joint infections.
Light-Driven H2-Evolution and C=C or C=O Bond Hydrogenation by Shewanella oneidensis: A Versatile Strategy for Photocatalysis by Nonphotosynthetic Microorganisms
Rowe, S. F., Le Gall, G., Ainsworth, E. V., Davies, J. A., Lockwood, C. W. J., Shi, L., Elliston, A., Roberts, I. N., Waldron, K. W., Richardson, D. J., Clarke, T. A., Jeuken, L. J. C., Reisner, E. & Butt, J. N. 19 Sep 2017 In : ACS Catalysis. 7, p. 7558–7566 9
Photoreduction of Shewanella oneidensis Extracellular Cytochromes by Organic Chromophores and Dye-Sensitized TiO2
Ainsworth, E. V., Lockwood, C. W. J., White, G. F., Hwang, E. T., Sakai, T., Gross, M. A., Richardson, D. J., Clarke, T. A., Jeuken, L. J. C., Reisner, E. & Butt, J. N. 14 Dec 2016 In : ChemBioChem. 17, 24, p. 2324–2333 https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201600339
Redox linked flavin sites in extracellular decaheme proteins involved in microbe-mineral electron transfer
Edwards, M., White, G., Norman, M., Tome-Fernandez, A., Ainsworth, E., Shi, L., Fredrickson, J., Zachara, J., Butt, J., Richardson, D. & Clarke, T. 1 Jul 2015 In : Scientific Reports. 5, 11677 http://www.nature.com/articles/srep11677
A Decaheme Cytochrome as a Molecular Electron Conduit in Dye-Sensitized Photoanodes
Hwang, E. T., Sheikh, K., Orchard, K., Hojo, D., Radu, V., Lee, C-Y., Ainsworth, E., Lockwood, C., Gross, M., Adschiri, T., Reisner, E., Butt, J. & Jeuken, L. J. C. 15 Apr 2015 In : Advanced Functional Materials. 25, 15, p. 2308–2315 8 https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201404541