Dr Emma Holden

Research Scientist

Investigating the evolution of antimicrobial resistance

Listeria and other invasive pathogens

View Mark Webber's group View Matthew Gilmour's group

Biography

I am a postdoctoral research scientist using functional genomics tools to investigate bacterial evolution and survival. I recently completed my PhD at the Quadram Institute using TraDIS-Xpress tools developed in-house to investigate bacterial biofilm formation and antimicrobial resistance. My postdoctoral work continues to use functional genomics and experimental evolution to investigate antimicrobial resistance, and I deliver TraDIS-Xpress projects for commercial partners.

Trampari E,Holden ER,Wickham GJ,Ravi A,de Oliveira Martins L,Savva GM,Webber MA. (2021)

Exposure of Salmonella biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs.

NPJ biofilms and microbiomes

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Gold Lock

HOLDEN ERH, WEBBER MAW, YASIR MY, TURNER AKT, WAIN JW, CHARLES IGC. (2021)

Massively parallel transposon mutagenesis identifies temporally essential genes for biofilm formation in Escherichia coli

Microbial Genomics

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Gold Lock

Trampari E., Webber M., Savva G., Martins L., Ravi A., Wickham G., Holden E.. (2020)

Exposure of Salmonella biofilms to sub-lethal concentrations of antibiotics rapidly selects for resistance but with collateral tradeoffs