Dr Emma Holden

Research Scientist

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Investigating the evolution of antimicrobial resistance

Listeria and other invasive pathogens

I am a postdoctoral research scientist using functional genomics tools to investigate bacterial evolution and survival. I recently completed my PhD at the Quadram Institute using TraDIS-Xpress tools developed in-house to investigate bacterial biofilm formation and antimicrobial resistance. My postdoctoral work continues to use functional genomics and experimental evolution to investigate antimicrobial resistance, and I deliver TraDIS-Xpress projects for commercial partners.

Acton L, Pye HV, Thilliez G, Kolenda R, Matthews M, Turner AK, Yasir M, Holden E, Al-Khanaq H, Webber M, Adriaenssens EM, Kingsley . (2024)

Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to control Salmonella enterica

Journal of Virology


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Darby EM, Moran RA, Holden E, Morris T, Harrison F, Clough B, McInnes RS, Schneider L, Frickel EM, Webber MA, Blair JMA. (2024)

Differential development of antibiotic resistance and virulence between Acinetobacter species.

mSphere


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Acton L, Pye HV, Thilliez G, Kolenda R, Matthews M, Turner AK, Yasir M, Holden E, Al-Khanaq H, Webber M, Adriaenssens EM, Kingsley RA. (2024)

Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to control Salmonella enterica.

Journal of virology


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Holden E, Abi Assaf J, Al-khanaq H, Vimont N, Webber M, Trampari E. (2023)

Identification of pathways required for Salmonella to colonise alfalfa using TraDIS-Xpress.

Applied and Environmental Microbiology


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Trampari E,Holden ER,Wickham GJ,Ravi A,de Oliveira Martins L,Savva GM,Webber MA. (2021)

Exposure of Salmonella biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs.

NPJ biofilms and microbiomes


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