Emma Holden

Research Scientist

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Investigating the evolution of antimicrobial resistance

Listeria and other invasive pathogens

I am a postdoc working with Matt Gilmour and Mark Webber investigating the mechanism of action of novel antimicrobials and bacterial survival strategies against these antimicrobials. I recently completed my PhD with Mark Webber on the relationships between biofilm formation and efflux activity in Enterobacteriaceae using TraDIS-Xpress, a massively parallel transposon mutagenesis approach developed at the Quadram Institute. Previous to my PhD, I completed an MSc in Biomedical Sciences Research from the University of Bristol and a BSc in Evolutionary Biology.

Trampari E,Holden ER,Wickham GJ,Ravi A,de Oliveira Martins L,Savva GM,Webber MA. (2021)

Exposure of Salmonella biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs.

NPJ biofilms and microbiomes

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Trampari E., Webber M., Savva G., Martins L., Ravi A., Wickham G., Holden E.. (2020)

Exposure of Salmonella biofilms to sub-lethal concentrations of antibiotics rapidly selects for resistance but with collateral tradeoffs

npj biofilms and microbes

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Holden ER,Wickham GJ,Webber MA,Thomson NM,Trampari E. (2020)

Donor plasmids for phenotypically neutral chromosomal gene insertions in Enterobacteriaceae.

Microbiology (Reading, England)

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