Dr Evelien Adriaenssens

Group Leader

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Gut viruses & viromics

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I am a molecular and computational microbiologist with a passion for everything viral.

I started my research career at the University of Leuven (KU Leuven, Belgium) investigating the use of bacteriophages (viruses of bacteria) as a biological control agent in potato plant production. As part of this project, co-funded by the Institute for Agricultural and Fisheries Research Flanders (ILVO), I isolated novel phages which I extensively characterised for commercial suitability, including genomics, production optimisation and in planta trials.

During my time as a postdoc (University of Pretoria, South Africa & University of Liverpool, UK), I specialised in viromics or viral metagenomics, to elucidate viral community diversity in a range of habitats. I have conducted research on extreme environments, such as the Namib Desert and the Antarctic Dry Valleys, where I studied several niche habitats such as hypoliths, hyperarid soil and saline springs. Using this expertise, I used viromics approaches to investigate the spread of pathogenic viruses from wastewater effluent into a river catchment area in the North of Wales and determine the potential for food- and waterborne illness (viraqua.uk).

I joined the Quadram Institute in January 2019 where my group is investigating the role of viruses, in particular bacteriophages, in the human gut, and how we can exploit some of these viruses to modulate the gut microbiome in health and disease.

I am the Chair of the Bacterial Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV).


Key Publications

Turner D, Kropinski AM, Adriaenssens EM, 2021, A roadmap for genome-based phage taxonomy, Viruses 13:506, doi 10.3390/v13030506

Roux S, Adriaenssens EM, … Eloe-Fadrosh, 2019, Minimum Information about an Uncultivated Virus Genome (MIUViG), Nature Biotechnology, 37, 29-37, doi 10.1038/nbt.4306

Owen, Perez-Sepulveda, Adriaenssens EM, 2018, Detection of Bacteriophages: Sequence-based systems, in Bacteriophages, Harper et al (eds), p621-644, doi 10.1007/978-3-319-41986-2_19

Adriaenssens EM, Brister JR, 2017, How to name and classify your phage: an informal guide, Viruses 9:70, doi 10.3390/v9040070

 

Pye HV, Krishnamurthy K, Cook R, Adriaenssens EM. (2024)

Phage Diversity in One Health.

Essays in Biochemistry


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Cook R, Crisci MA, Pye HV, Telatin A, Adriaenssens EM, Santini JM. (2024)

Decoding huge phage diversity: a taxonomic classification of Lak megaphages

Journal of General Virology


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Cook R, Telatin A, Bouras G, Camargo AP, Larralde M, Edwards RA, Adriaenssens EM. (2024)

Driving through stop signs: predicting stop codon reassignment improves functional annotation of bacteriophages

ISME Communications


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Cook R, Telatin A, Hsieh E, Newberry F, Tariq M, Baker D, Carding S, Adriaenssens . (2024)

Nanopore and Illumina sequencing reveal different viral populations from human gut samples

Microbial Genomics


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Dominic C, Pye HV, Mishra EK, Adriaenssens E. (2024)

Bacteriophages for bronchiectasis: treatment of the future?

Current opinion in pulmonary medicine


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Acton L, Pye HV, Thilliez G, Kolenda R, Matthews M, Turner AK, Yasir M, Holden E, Al-Khanaq H, Webber M, Adriaenssens EM, Kingsley . (2024)

Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to control Salmonella enterica

Journal of Virology


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Turner D, Shkoporov AN, Lood C, Millard AD, Dutilh BE, Alfenas-Zerbini P, Van Zyl LJ, Aziz RK, Oksanen HM, Poranen MM, Kropinski AM, Barylski J, Brister JR, Chanisvili N, Edwards RA, Enault F, Gillis A, Knezevic P, Krupovic M, Kurtböke I, Kushkina A, Lavigne R, Lehman S, Lobocka M, Moraru C, Moreno Switt A, Morozova V, Nakavuma J, Reyes Muñoz A, Rumnieks J, Sarkar BL, Sullivan MB, Uchiyama J, Wittmann J, Tong Y, Adriaenssens E. (2023)

Abolishment of morphology-based taxa and change to binomial species names: 2022 taxonomy update of the ICTV bacterial viruses subcommittee

Archives of Virology, 168, 74


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