Dr Evelien Adriaenssens

Group Leader

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Gut viruses & viromics

Links/websites:

I am a molecular and computational microbiologist with a passion for everything viral.

I started my research career at the University of Leuven (KU Leuven, Belgium) investigating the use of bacteriophages (viruses of bacteria) as a biological control agent in potato plant production. As part of this project, co-funded by the Institute for Agricultural and Fisheries Research Flanders (ILVO), I isolated novel phages which I extensively characterised for commercial suitability, including genomics, production optimisation and in planta trials.

During my time as a postdoc (University of Pretoria, South Africa & University of Liverpool, UK), I specialised in viromics or viral metagenomics, to elucidate viral community diversity in a range of habitats. I have conducted research on extreme environments, such as the Namib Desert and the Antarctic Dry Valleys, where I studied several niche habitats such as hypoliths, hyperarid soil and saline springs. Using this expertise, I used viromics approaches to investigate the spread of pathogenic viruses from wastewater effluent into a river catchment area in the North of Wales and determine the potential for food- and waterborne illness (viraqua.uk).

I joined the Quadram Institute in January 2019 where my group is investigating the role of viruses, in particular bacteriophages, in the human gut, and how we can exploit some of these viruses to modulate the gut microbiome in health and disease.

I am the Chair of the Bacterial Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV).


Key Publications

Turner D, Kropinski AM, Adriaenssens EM, 2021, A roadmap for genome-based phage taxonomy, Viruses 13:506, doi 10.3390/v13030506

Roux S, Adriaenssens EM, … Eloe-Fadrosh, 2019, Minimum Information about an Uncultivated Virus Genome (MIUViG), Nature Biotechnology, 37, 29-37, doi 10.1038/nbt.4306

Owen, Perez-Sepulveda, Adriaenssens EM, 2018, Detection of Bacteriophages: Sequence-based systems, in Bacteriophages, Harper et al (eds), p621-644, doi 10.1007/978-3-319-41986-2_19

Adriaenssens EM, Brister JR, 2017, How to name and classify your phage: an informal guide, Viruses 9:70, doi 10.3390/v9040070

 

Cook R, Telatin A, Hsieh E, Newberry F, Tariq M, Baker D, Carding S, Adriaenssens . (2024)

Nanopore and Illumina sequencing reveal different viral populations from human gut samples

Microbial Genomics


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Dominic C, Pye HV, Mishra EK, Adriaenssens E. (2024)

Bacteriophages for bronchiectasis: treatment of the future?

Current opinion in pulmonary medicine


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Acton L, Pye HV, Thilliez G, Kolenda R, Matthews M, Turner AK, Yasir M, Holden E, Al-Khanaq H, Webber M, Adriaenssens EM, Kingsley . (2024)

Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to control Salmonella enterica

Journal of Virology


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Siddell SG, Smith DB, Adriaenssens E, Alfenas-Zerbini P, Dutilh BE, Garcia ML, Junglen S, Krupovic M, Kuhn JH, Lambert AJ, Lefkowitz EJ, Lobocka M, Mushegian AR, Oksanen HM, Robertson DL, Rubino L, Sabanadzovic S, Simmonds P, Suzuki N, Van Doorslaer K, Vandamme AM, Varsani A, Zerbini F. (2023)

Virus taxonomy and the role of the International Committee on Taxonomy of Viruses (ICTV)

Journal of General Virology, 104, 001840


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Hsieh SY, Savva GM, Telatin A, Tiwari SK, Tariq MA, Newberry F, Seton KA, Booth C, Bansal AS, Adriaenssens EM, Wileman T, Carding S. (2023)

Investigating the Human Intestinal DNA Virome and Predicting Disease-Associated VirusHost Interactions in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

International Journal of Molecular Sciences


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Adriaenssens EM, Roux S, Brister JR, Karsch-Mizrachi I, Kuhn JH, Varsani A, Yigang T, Reyes A, Lood C, Lefkowitz EJ, Sullivan MB, Edwards RE, Simmonds P, Rubino L, Sabanadzovic S, Krupovic M, Dutilh B. (2023)

Guidelines for public database submission of uncultivated virus genome sequences for taxonomic classification

Nature Biotechnology, 41, 898-902


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Elek C, Brown T, Le Viet T, Evans R, Baker D, Telatin A, Tiwari S, Al-Khanaq H, Thilliez G, Kingsley R, Hall L, Webber M, Adriaenssens . (2023)

A hybrid and poly-polish workflow for the complete and accurate assembly of phage genomes: a case study of ten przondoviruses

Microbial Genomics, 9


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