Dr Fred Warren
Starch breakdown in the digestive tract
My degree and PhD were both obtained in Biochemistry at King’s College London, with the later focusing on kinetic methods assessing starch digestion rates, understanding links between starch structure and digestion. I then worked at PerkinElmer, where I developed expertise in a range of analytical thermal and spectroscopic methods, before moving to the University of Queensland on a post-doctoral fellowship.
During my time in Queensland I developed an interest in the colonic fermentation of carbohydrates, and links between carbohydrate structure and fermentation, as well as continuing to work on analytical methods for determining starch molecular structure.
In 2015 I returned to the UK to take up a post as a group leader at the Institute of Food Research, now Quadram Institute, where I am also a Marie Curie Research Fellow.
The main focus of my research group at QI is modelling the behaviour of starchy foods throughout the digestive tract, from oral processing through stomach and small intestinal digestion, and subsequent colonic fermentation. Through manipulation of starch structure through processing, enzyme modification and plant breeding we aim to produce starch based foods which have controlled digestion and fermentation characteristics.
P.J. Butterworth; F.J. Warren; T. Grassby; H. Patel & P.R. Ellis. Analysis of starch amylolysis using plots for first-order kinetics. Carbohydrate Polymers (2012) 87, 2189-2197.
B.M. Flanagan, M.J. Gidley, F.J. Warren. Rapid quantification of starch molecular order through multivariate modelling of 13C CP/MAS NMR spectra. Chemical Communications (2015) 51, 14856-14858
Zou, M. Sissons, M.J. Gidley, R.G. Gilbert, F.J. Warren. Combined techniques for characterising pasta structure reveals how the gluten network slows enzymic digestion rate. Food chemistry, (2015) 188, 559-568
F.J. Warren, B.B. Perston, S.P. Galindez‐Najera, C.H. Edwards, P.O. Powell, G. Mandalari, G.M. Campbell, P.J Butterworth, P.R. Ellis. Infrared microspectroscopic imaging of plant tissues: spectral visualization of Triticum aestivum kernel and Arabidopsis leaf microstructure. The Plant Journal (2015) 84, 634-646
F.J. Warren; P.G. Royall; S. Gaisford; P.J. Butterworth & P.R. Ellis. Binding interactions of alpha-amylase with starch granules: The influence of supramolecular structure and surface area. Carbohydrate Polymers (2011) 86, 1038-104
Starch hydrogels as targeted colonic drug delivery vehicles
Enzyme kinetic approach for mechanistic insight and predictions of in vivo starch digestibility and the glycaemic index of foods
Trends in Food Science and Technology, 120, 254-264
Comparison of the behavior of fungal and plant cell wall during gastrointestinal digestion and resulting health effects: A review
Trends in Food Science & Technology, 110, 132-141