Dr Gemma Langridge

Group Leader

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Bacterial niche adaptation


My interests lie in using comparative genomics, transposon mutagenesis and metabolic reconstruction methods to unpick the impact of genetic mutations upon bacterial niche adaptation.

I completed my undergraduate degree in Biological Sciences at the University of Oxford and went on to study for my PhD at the Wellcome Trust Sanger Institute, where I used both experimental and bioinformatic approaches to investigate the metabolic capacity of closely related salmonellae. At this time, I was part of the team that developed transposon directed insertion-site sequencing (TraDIS), which we used to investigate the essential gene set of Salmonella Typhi grown under laboratory conditions and in the presence of bile. Since then, I have been involved with projects utilising TraDIS in E. coli, Salmonella, C. difficile, Bordetella, Pseudomonas and Staphylococcus.

In 2016, I moved to the UNiversity of East Anglia (UEA) to study the genetics of the non-aureus staphylococci, in particular relating to their biofilm forming ability. I also undertook a large-scale screen to identify antibiotic resistance determinants across a collection of >400 non-aureus strains before taking up this position at the Quadram Institute in late 2018.

Key Publications

Djeghout B, Saha S, Sajib MSI, Tanmoy AM, Islam M, Kay GL, Langridge GC, Endtz H, Wain J and Saha S (2018). Ceftriaxone-resistant Salmonella Typhi carries an IncI1-ST31 plasmid encoding CTX-M-15. J Med Micro 67: 620-627. 2. https://doi.org/10.1099/jmm.0.000727

Langridge GC, et al (2015). Patterns of genome evolution that have accompanied host adaptation in Salmonella. Proc Natl Acad Sci 112 (3): 863-868. 3. https://doi.org/10.1073/pnas.1416707112

Barquist L, Langridge GC, et al (2013). A comparison of dense transposon insertion libraries in the Salmonella serovars Typhi and Typhimurium. Nucl Acid Res 41 (8): 4549-4564. 4. https://doi.org/10.1093/nar/gkt148

Fookes M, Schroeder GN, Langridge GC, et al (2011). Salmonella bongori provides insights into the evolution of the salmonellae. PLoS Pathog 7(8): e1002191. 5. https://doi.org/10.1371/journal.ppat.1002191

Langridge GC et al (2009). Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants. Genome Res 19: 2308-2316. https://doi.org/10.1101/gr.097097.109

Diaz-Calvo T, Tejera-Hernandez N, McNamara I, Langridge G, Wain J, Poolman M, Singh . (2022)

Genome-Scale Metabolic Modelling Approach to Understand Metabolism of the Opportunistic Human Pathogen Staphylococcus epidermidis RP62A

Metabolites, 12(2)

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Nair S,Chattaway M,Langridge G,Gentle A,Day M,Ainsworth EV,Mohamed I,Smith R,Jenkins C,Dallman TJ,Godbole G. (2021)

ESBL-producing strains isolated from imported cases of enteric fever in England and Wales reveal multiple chromosomal integrations of blaCTX-M-15 in XDR Salmonella Typhi.

The Journal of Antimicrobial Chemotherapy

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Chattaway MA,Langridge GC,Wain J. (2021)

Salmonella nomenclature in the genomic era: a time for change.

Scientific Reports

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Lee WWY, Mattock J, Greig DR, Langridge GC, Baker D, Bloomfield S, Mather AE, Wain JR, Edwards AM, Hartman H, Dallman TJ, Chattaway MA, Nair S. (2021)

Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales

Microbial Genomics, 7, 10

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Nair S., Fookes M., Corton C., Thomson N. R., Wain J., Langridge G. C.. (2020)

Genetic markers in S. Paratyphi C reveal primary adaptation to pigs

Microorganisms, 8(5), 657

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