My interests lie in using comparative genomics, transposon mutagenesis and metabolic reconstruction methods to unpick the impact of genetic mutations upon bacterial niche adaptation.
I completed my undergraduate degree in Biological Sciences at the University of Oxford and went on to study for my PhD at the Wellcome Trust Sanger Institute, where I used both experimental and bioinformatic approaches to investigate the metabolic capacity of closely related salmonellae. At this time, I was part of the team that developed transposon directed insertion-site sequencing (TraDIS), which we used to investigate the essential gene set of Salmonella Typhi grown under laboratory conditions and in the presence of bile. Since then, I have been involved with projects utilising TraDIS in E. coli, Salmonella, C. difficile, Bordetella, Pseudomonas and Staphylococcus.
In 2016, I moved to the UNiversity of East Anglia (UEA) to study the genetics of the non-aureus staphylococci, in particular relating to their biofilm forming ability. I also undertook a large-scale screen to identify antibiotic resistance determinants across a collection of >400 non-aureus strains before taking up this position at the Quadram Institute in late 2018.
- Djeghout B, Saha S, Sajib MSI, Tanmoy AM, Islam M, Kay GL, Langridge GC, Endtz H, Wain J and Saha S (2018). Ceftriaxone-resistant Salmonella Typhi carries an IncI1-ST31 plasmid encoding CTX-M-15. J Med Micro 67: 620-627. 2.
- Langridge GC, et al (2015). Patterns of genome evolution that have accompanied host adaptation in Salmonella. Proc Natl Acad Sci 112 (3): 863-868. 3. Barquist L, Langridge GC, et al (2013). A comparison of dense transposon insertion libraries in the Salmonella serovars Typhi and Typhimurium. Nucl Acid Res 41 (8): 4549-4564. 4.
- Fookes M, Schroeder GN, Langridge GC, et al (2011). Salmonella bongori provides insights into the evolution of the salmonellae. PLoS Pathog 7(8): e1002191. 5.
- Langridge GC et al (2009). Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants. Genome Res 19: 2308-2316.