Dr Gemma Langridge

Group Leader

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Bacterial niche adaptation

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My interests lie in using comparative genomics, transposon mutagenesis and metabolic reconstruction methods to unpick the impact of genetic mutations upon bacterial niche adaptation.

I completed my undergraduate degree in Biological Sciences at the University of Oxford and went on to study for my PhD at the Wellcome Trust Sanger Institute, where I used both experimental and bioinformatic approaches to investigate the metabolic capacity of closely related salmonellae. At this time, I was part of the team that developed transposon directed insertion-site sequencing (TraDIS), which we used to investigate the essential gene set of Salmonella Typhi grown under laboratory conditions and in the presence of bile. Since then, I have been involved with projects utilising TraDIS in E. coli, Salmonella, C. difficile, Bordetella, Pseudomonas and Staphylococcus.

In 2016, I moved to the UNiversity of East Anglia (UEA) to study the genetics of the non-aureus staphylococci, in particular relating to their biofilm forming ability. I also undertook a large-scale screen to identify antibiotic resistance determinants across a collection of >400 non-aureus strains before taking up this position at the Quadram Institute in late 2018.


Key Publications

Djeghout B, Saha S, Sajib MSI, Tanmoy AM, Islam M, Kay GL, Langridge GC, Endtz H, Wain J and Saha S (2018). Ceftriaxone-resistant Salmonella Typhi carries an IncI1-ST31 plasmid encoding CTX-M-15. J Med Micro 67: 620-627. 2. https://doi.org/10.1099/jmm.0.000727

Langridge GC, et al (2015). Patterns of genome evolution that have accompanied host adaptation in Salmonella. Proc Natl Acad Sci 112 (3): 863-868. 3. https://doi.org/10.1073/pnas.1416707112

Barquist L, Langridge GC, et al (2013). A comparison of dense transposon insertion libraries in the Salmonella serovars Typhi and Typhimurium. Nucl Acid Res 41 (8): 4549-4564. 4. https://doi.org/10.1093/nar/gkt148

Fookes M, Schroeder GN, Langridge GC, et al (2011). Salmonella bongori provides insights into the evolution of the salmonellae. PLoS Pathog 7(8): e1002191. 5. https://doi.org/10.1371/journal.ppat.1002191

Langridge GC et al (2009). Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants. Genome Res 19: 2308-2316. https://doi.org/10.1101/gr.097097.109

Dicks J, Fazal MA, Oliver K, Grayson NE, Turnbull JD, Bane E, Burnett E, Deheer-Graham A, Holroyd N, Kaushal D, Keane J, Langridge G, Lomax J, McGregor H, Picton S, Quail M, Singh D, Tracey A, Korlach J, Russell JE, Alexander S, Parkhill . (2023)

NCTC3000: a century of bacterial strain collecting leads to a rich genomic data resource.

Microbial Genomics


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Carter C, Hutchison A, Rudder S, Trotter E, Waters EV, Elumogo N, Langridge G. (2023)

Uropathogenic Escherichia coli population structure and antimicrobial susceptibility in Norfolk, UK.

The Journal of antimicrobial chemotherapy


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Felgate H, Sethi D, Fuast K, Kiy C, Hartel C, Rupp J, Dean R, Tremlett C, Wain J, Langridge G, Clarke P, Page A, Webber . (2023)

Characterisation of neonatal Staphylococcus capitis NRCS-A isolates compared with non NRCS-A Staphylococcus capitis from neonates and adults.

Microbial Genomics, 9


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Felgate H, Crossman LC, Gray E, Clifford R, Correia A, Dean R, Wain J, Langridge G. (2023)

Known mechanisms cannot account for a third of reduced susceptibility in non-aureus staphylococci

npj Antimicrobials and Resistance, 15


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Carey ME, Dyson ZA, Ingle DJ, Amir A, Aworh MK, Chattaway MA, Chew KL, Crump JA, Feasey NA, Howden BP, Keddy KH, Maes M, Parry CM, Van Puyvelde, Webb HE, Afolayan AO, Alexander AP, Anandan S, Andrews JR, Ashton PM, Basnyat B, Bavdekar A, Bogoch II, Clemens JD, da Silva, De A, de Ligt, Diaz Guevara, Dolecek C, Dutta S, Ehlers MM, Francois Watkins, Garrett DO, Godbole G, Gordon MA, Greenhill AR, Griffin C, Gupta M, Hendriksen RS, Heyderman RS, Hooda Y, Hormazabal JC, Ikhimiukor OO, Iqbal J, Jacob JJ, Jenkins C, Jinka DR, John J, Kang G, Kanteh A, Kapil A, Karkey A, Kariuki S, Kingsley R, Koshy RM, Lauer AC, Levine MM, Lingegowda RK, Luby SP, Mackenzie GA, Mashe T, Msefula C, Mutreja A, Nagaraj G, Nagaraj S, Nair S, Naseri TK, Nimarota-Brown S, Njamkepo E, Okeke IN, Perumal SPB, Pollard AJ, Pragasam AK, Qadri F, Qamar FN, Rahman SIA, Rambocus SD, Rasko DA, Ray P, Robins-Browne R, Rongsen-Chandola T, Rutanga JP, Saha SK, Saha S, Saigal K, Sajib MSI, Seidman JC, Shakya J, Shamanna V, Shastri J, Shrestha R, Sia S, Sikorski MJ, Singh A, Smith AM, Tagg KA, Tamrakar D, Tanmoy AM, Thomas M, Thomas MS, Thomsen R, Thomson NR, Tupua S, Vaidya K, Valcanis M, Veeraraghavan B, Weill FX, Wright J, Dougan G, Argimón S, Keane JA, Aanensen DM, Baker S, Holt KE, Aaby P, Abbas A, Ahmed N, Andleeb S, Aseffa A, Baker KS, Bentsi-Enchill A, Breiman RF, Britto C, Campos J, Chen CJ, Chiou CS, Davong V, Faiz A, Gul D, Hasan R, Hatta M, Ikram A, Isaia L, Jacobs J, Kariuki S, Khokhar F, Klemm E, Kuijpers LMF, Langridge G, Lim K, Lunguya O, Luquero F, MacLennan CA, Marks F, Morita M, Muchimba M, Mwansa JCL, Mwape K, Mwenda JM, Nash J, Neuzil KM, Newton P, Obaro S, Octavia S, Ohnishi M, Owusu M, Owusu-Dabo E, Park SE, Parkhill J, Pham DT, Phoba MF, Pickard DJ, Rakotozandrindrainy R, Ramon-Pardo P, Rasheed F, Rokney A, Rupali P, Sah R, Shakoor S, Simuyand M, Sooka A, Stanaway JD, Steele AD, Tack B, Tall A, Taneja N, Teferi M, Tessema S, Thilliez G, Turner P, Ussher JE, Villanueva AM, Weimer B, Wong VK, Founou R. (2023)

Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes.

eLife


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Mattock J, Smith AM, Keddy KH, Manners EJ, Duze ST, Smouse S, Tau N, Baker D, Chattaway MA, Mather AE, Wain J, Langridge G. (2022)

Genetic characterization of Salmonella Infantis from South Africa, 2004-2016.

Access microbiology


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