Dr George Savva

Statistician

Contact via email

Core Science Resources - methods development and innovation

Links/websites:

My role at the Quadram Institute is to support our scientists and the institute in all statistical aspects of research, quality assurance and governance.

I have worked as a statistician in health and medical sciences since 2004.  Between 2004 and 2013 I supported large national epidemiologic studies; the National Down Syndrome Cytogenetic Register, the Medical Research Council Cognitive Function and Ageing Study, and The Irish Longitudinal Study on Ageing.

I graduated with a degree in mathematics from the University of Cambridge in 2000, then a MSc in Applied Statistics from UCL in 2001.  My PhD was supervised by Jo Dicks at the John Innes Centre on the topic of statistical inference for whole genome phylogenetic analysis.

As Senior Lecturer at UEA between 2013 and 2017 I led a research programme in the epidemiology of ageing and dementia, and retain an interest in the conceptualization of the frailty and in the effects of potentially inappropriate medication use in older age.  I developed and led the training in statistics for doctoral students in the faculty of medicine and health during this time.


Key Publications

Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Age, neuropathology, and dementia. N Engl J Med. 2009 May 28;360(22):2302-9. doi: 10.1056/NEJMoa0806142.

Savva GM, Arthur A. Who has undiagnosed dementia? A cross-sectional analysis of participants of the Aging, Demographics and Memory Study. Age Ageing. 2015 Jul;44(4):642-7. doi: 10.1093/ageing/afv020.

Feeney J, Savva GM, O’Regan C, King-Kallimanis B, Cronin H, Kenny RA. Measurement Error, Reliability, and Minimum Detectable Change in the Mini-Mental State Examination, Montreal Cognitive Assessment, and Color Trails Test among Community Living Middle-Aged and Older Adults. J Alzheimers Dis. 2016 May 31;53(3):1107-14. doi: 10.3233/JAD-160248.

Kenny RA, Coen RF, Frewen J, Donoghue OA, Cronin H, Savva GM. Normative values of cognitive and physical function in older adults: findings from the Irish Longitudinal Study on Ageing. J Am Geriatr Soc. 2013 May;61 Suppl 2:S279-90. doi:
10.1111/jgs.12195

Stoakes E, Savva G, Coates R, Tejera N, Poolman M, Grant A, Wain J, Singh . (2022)

Substrate utilisation and energy metabolism in non-growing Campylobacter jejuni M1cam

Microorganism


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Hazard B, Fahy B, Gonzalez O, Savva G, Ahn-Jarvis J, Warren F, Lovegrove A, Dunn . (2022)

Loss of Starch Synthase IIIa changes starch molecular structure and granule morphology in grains of hexaploid bread wheat

Scientific Reports, 12, 10806


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Parker A, Romano S, Ansorge R, Aboelnoer A, Le Gall G, Savva G, Telatin A, Jones E, Baker D, Rudder S, Blackshaw LA, Jeffery G, Carding S. (2022)

Heterochronic fecal microbiota transfer reverses hallmarks of the aging gut, brain, and eye.

Microbiome


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Aggarwal D, Page A, Schaefer U, Savva GM, Myers R, Volz E, Ellaby N, Platt S, Groves N, Gallagher E, Tumelty NM, Le Viet, Hughes GJ, Chen C, Turner C, Logan S, Harrison A, Peacock SJ, Chand M, Harrison EM, Koshy C, Ash A, Wise E, Moore N, Mori M, Cortes N, Lynch J, Kidd S, Fairley DJ, Curran T, McKenna JP, Adams H, Fraser C, Golubchik T, Bonsall D, Hassan-Ibrahim MO, Malone CS, Cogger BJ, Wantoch M, Reynolds N, Warne B, Maksimovic J, Spellman K, McCluggage K, John M, Beer R, Afifi S, Morgan S, Marchbank A, Price A, Kitchen C, Gulliver H, Merrick I, Southgate J, Guest M, Munn R, Workman T, Connor TR, Fuller W, Bresner C, Snell LB, Patel A, Charalampous T, Nebbia G, Batra R, Edgeworth J, Robson SC, Beckett AH, Aanensen DM, Underwood AP, Yeats CA, Abudahab K, Taylor BEW, Menegazzo M, Clark G, Smith W, Khakh M, Fleming VM, Lister MM, Howson-Wells HC, Berry L, Boswell T, Joseph A, Willingham I, Jones C, Holmes C, Bird P, Helmer T, Fallon K, Tang J, Raviprakash V, Campbell S, Sheriff N, Blakey V, Williams LA, Loose MW, Holmes N, Moore C, Carlile M, Wright V, Sang F, Debebe J, Coll F, Signell AW, Betancor G, Wilson HD, Eldirdiri S, Kenyon A, Davis T, Pybus OG, du Plessis, Zarebski AE, Raghwani J, Kraemer MUG, Francois S, Attwood SW, Vasylyeva TI, Zamudio ME, Gutierrez B, Torok ME, Hamilton WL, Goodfellow IG, Hall G, Jahun AS, Chaudhry Y, Hosmillo M, Pinckert ML, Georgana I, Moses S, Lowe H, Bedford L, Moore J, Stonehouse S, Fisher CL, Awan AR, BoYes J, Breuer J, Harris KA, Brown JR, Shah D, Atkinson L, Lee JCD, Storey N, Flaviani F, Alcolea-Medina A, Williams R, Vernet G, Chapman MR, Levett LJ, Heaney J, Chatterton W, Pusok M, Xu-McCrae L, Smith DL, Bashton M, Young GR, Holmes A, Randell PA, Cox A, Madona P, Bolt F, Price J, Mookerjee S, Ragonnet-Cronin M, Nascimento FF, Jorgensen D, Siveroni I, Johnson R, Boyd O, Geidelberg L, Volz EM, Rowan A, Taylor GP, Smollett KL, Loman NJ, Quick J, McMurray C, Stockton J, Nicholls S, Rowe W, Poplawski R, McNally A, Nunez RTM, Mason J, Robinson TI, O'Toole E, Watts J, Breen C, Cowell A, Sluga G, Machin NW, Ahmad SSY, George RP, Halstead F, Sivaprakasam V, Hogsden W, Illingworth CJ, Jackson C, Thomson EC, Shepherd JG, Asamaphan P, Niebel MO, Li KK, Shah RN, Jesudason NG, Tong L, Broos A, Mair D, Nichols J, Carmichael SN, Nomikou K, Aranday-Cortes E, Johnson N, Starinskij I, da Silva, Robertson DL, Orton RJ, Hughes J, Vattipally S, Singer JB, Nickbakhsh S, Hale AD, Macfarlane-Smith LR, Harper KL, Carden H, Taha Y, Payne BAI, Burton-Fanning S, Waugh S, Collins J, Eltringham G, Rushton S, O'Brien S, Bradley A, Maclean A, Mollett G, Blacow R, Templeton KE, McHugh MP, Dewar R, Wastenge E, Dervisevic S, Stanley R, Meader EJ, Coupland L, Smith L, Graham C, Barton E, Padgett D, Scott G, Swindells E, Greenaway J, Nelson A, McCann CM, Yew WC, Andersson M, Peto T, Justice A, Eyre D, Crook D, Sloan TJ, Duckworth N, Walsh S, Chauhan AJ, Glaysher S, Bicknell K, Wyllie S, Elliott S, Lloyd A, Impey R, Levene N, Monaghan L, Bradley DT, Wyatt T, Allara E, Pearson C, Osman H, Bosworth A, Robinson E, Muir P, Vipond IB, Hopes R, Pymont HM, Hutchings S, Curran MD, Parmar S, Lackenby A, Mbisa T, Miah S, Bibby D, Manso C, Hubb J, Dabrera G, Ramsay M, Bradshaw D, Thornton A, Gallagher E, Lee D, Williams D, Harrison I, Hartman H, Manesis N, Patel V, Bishop C, Chalker V, Ledesma J, Twohig KA, Holden MTG, Shaaban S, Birchley A, Adams A, Davies A, Gaskin A, Plimmer A, Gatica-Wilcox B, McKerr C, Moore C, Williams C, Heyburn D, De Lacy, Hilvers E, Downing F, Shankar G, Jones H, Asad H, Coombes J, Watkins J, Evans JM, Fina L, Gifford L, Gilbert L, Graham L, Perry M, Morgan M, Bull M, Cronin M, Pacchiarini N, Craine N, Jones R, Howe R, Corden S, Rey S, Kumziene-SummerhaYes S, Taylor S, Cottrell S, Jones S, Edwards S, O'Grady J, Mather AE, Baker DJ, Rudder S, Aydin A, Kay GL, Trotter AJ, Alikhan NF, de Oliveira, Le-Viet T, Meadows L, Casey A, Ratcliffe L, Simpson DA, Molnar Z, Thompson T, Acheson E, Masoli JAH, Knight BA, Ellard S, Auckland C, Jones CR, Mahungu TW, Irish-Tavares D, Haque T, Hart J, Witele E, Fenton ML, Dadrah A, Symmonds A, Saluja T, Bourgeois Y, Scarlett GP, Loveson KF, Goudarzi S, Fearn C, Cook K, Dent H, Paul H, Partridge DG, Raza M, Evans C, Johnson K, Liggett S, Baker P, Bonner S, Essex S, Lyons RA, Saeed K, Mahanama AIK, Samaraweera B, Silveira S, Pelosi E, Wilson-Davies E, Williams RJ, Kristiansen M, Roy S, Williams CA, Cotic M, Bayzid N, Westhorpe AP, Hartley JA, Jannoo R, Lowe HL, Karamani A, Ensell L, Prieto JA, Jeremiah S, Grammatopoulos D, Pandey S, Berry L, Jones K, Richter A, Beggs A, Best A, Percival B, Mirza J, Megram O, Mayhew M, Crawford L, Ashcroft F, Moles-Garcia E, Cumley N, Smith CP, Bucca G, Hesketh AR, Blane B, Girgis ST, Leek D, Sridhar S, Forrest S, Cormie C, Gill HK, Dias J, Higginson EE, Maes M, Young J, Kermack LM, Gupta RK, Ludden C, Peacock SJ, Palmer S, Churcher CM, Hadjirin NF, Carabelli AM, Brooks E, Smith KS, Galai K, McManus GM, Ruis C, Davidson RK, Rambaut A, Williams T, Balcazar CE, Gallagher MD, O'Toole Á, Rooke S, Hill V, Williamson KA, Stanton TD, Michell SL, Bewshea CM, Temperton B, Michelsen ML, Warwick-Dugdale J, Manley R, Farbos A, Harrison JW, Sambles CM, Studholme DJ, Jeffries AR, Darby AC, Hiscox JA, Paterson S, Iturriza-Gomara M, Jackson KA, Lucaci AO, Vamos EE, Hughes M, Rainbow L, Eccles R, Nelson C, Whitehead M, Turtle L, Haldenby ST, Gregory R, Gemmell M, Wierzbicki C, Webster HJ, de Silva, Smith N, Angyal A, Lindsey BB, Groves DC, Green LR, Wang D, Freeman TM, Parker MD, Keeley AJ, Parsons PJ, Tucker RM, Brown R, Wyles M, Whiteley M, Zhang P, Gallis M, Louka SF, Constantinidou C, Unnikrishnan M, Ott S, Cheng JKJ, Bridgewater HE, Frost LR, Taylor-Joyce G, Stark R, Baxter L, Alam MT, Brown PE, Aggarwal D, Cerda AC, Merrill TV, Wilson RE, McClure PC, Chappell JG, Tsoleridis T, Ball J, Buck D, Todd JA, Green A, Trebes A, MacIntyre-Cockett G, de Cesare, Alderton A, Amato R, Ariani CV, Beale MA, Beaver C, Bellis KL, Betteridge E, Bonfield J, Danesh J, Dorman MJ, Drury E, Farr BW, Foulser L, Goncalves S, Goodwin S, Gourtovaia M, Harrison EM, Jackson DK, Jamrozy D, Johnston I, Kane L, Kay S, Keatley JP, Kwiatkowski D, Langford CF, Lawniczak M, Letchford L, Livett R, Lo S, Martincorena I, McGuigan S, Nelson R, Palmer S, Park NR, Patel M, Prestwood L, Puethe C, Quail MA, Rajatileka S, Scott C, Shirley L, Sillitoe J, Chapman MHS, Thurston SAJ, Tonkin-Hill G, Weldon D, Rajan D, Bronner IF, Aigrain L, Redshaw NM, Lensing SV, Davies R, Whitwham A, Liddle J, Lewis K, Tovar-Corona JM, Leonard S, Durham J, Bassett AR, McCarthy S, Moll RJ, James K, Oliver K, Makunin A, Barrett J, Gunson R. (2022)

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission.

Nature communications


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Trampari E,Holden ER,Wickham GJ,Ravi A,de Oliveira Martins L,Savva GM,Webber MA. (2021)

Exposure of Salmonella biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs.

NPJ biofilms and microbiomes


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