Dr George Savva

Statistician

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Core Science Resources - methods development and innovation

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My role at the Quadram Institute is to support our scientists and the institute in all statistical aspects of research, quality assurance and governance.

I have worked as a statistician in health and medical sciences since 2004.  Between 2004 and 2013 I supported large national epidemiologic studies; the National Down Syndrome Cytogenetic Register, the Medical Research Council Cognitive Function and Ageing Study, and The Irish Longitudinal Study on Ageing.

I graduated with a degree in mathematics from the University of Cambridge in 2000, then a MSc in Applied Statistics from UCL in 2001.  My PhD was supervised by Jo Dicks at the John Innes Centre on the topic of statistical inference for whole genome phylogenetic analysis.

As Senior Lecturer at UEA between 2013 and 2017 I led a research programme in the epidemiology of ageing and dementia, and retain an interest in the conceptualization of the frailty and in the effects of potentially inappropriate medication use in older age.  I developed and led the training in statistics for doctoral students in the faculty of medicine and health during this time.


Key Publications

Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Age, neuropathology, and dementia. N Engl J Med. 2009 May 28;360(22):2302-9. doi: 10.1056/NEJMoa0806142.

Savva GM, Arthur A. Who has undiagnosed dementia? A cross-sectional analysis of participants of the Aging, Demographics and Memory Study. Age Ageing. 2015 Jul;44(4):642-7. doi: 10.1093/ageing/afv020.

Feeney J, Savva GM, O’Regan C, King-Kallimanis B, Cronin H, Kenny RA. Measurement Error, Reliability, and Minimum Detectable Change in the Mini-Mental State Examination, Montreal Cognitive Assessment, and Color Trails Test among Community Living Middle-Aged and Older Adults. J Alzheimers Dis. 2016 May 31;53(3):1107-14. doi: 10.3233/JAD-160248.

Kenny RA, Coen RF, Frewen J, Donoghue OA, Cronin H, Savva GM. Normative values of cognitive and physical function in older adults: findings from the Irish Longitudinal Study on Ageing. J Am Geriatr Soc. 2013 May;61 Suppl 2:S279-90. doi:
10.1111/jgs.12195

Corrado M, Zafeiriou P, Ahn-Jarvis J, Savva G, Edwards CH, Hazard B. (2023)

Impact of storage on starch digestibility and texture of a high-amylose wheat bread

Food Hydrocolloids, 135


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Coletto E, Savva GM, Latousakis D, Pontifex M, Crost EH, Vaux L, Telatin A, Bergstrom K, Vauzour D, Juge . (2023)

Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice.

Scientific reports


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Seton KA, Carding SR, Defernez M, Telatin A, Tiwari SK, Savva GM, Hayhoe A, Noble A, Carvalho A, James S, Bansal A, Wileman . (2023)

Investigating antibody reactivity to the intestinal microbiome in severe myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A feasibility study.

International journal of molecular sciences, 24, 15316


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Hsieh SY, Savva GM, Telatin A, Tiwari SK, Tariq MA, Newberry F, Seton KA, Booth C, Bansal AS, Adriaenssens EM, Wileman T, Carding S. (2023)

Investigating the Human Intestinal DNA Virome and Predicting Disease-Associated VirusHost Interactions in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

International Journal of Molecular Sciences


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Stoakes E, Savva G, Coates R, Tejera N, Poolman M, Grant A, Wain J, Singh . (2022)

Substrate utilisation and energy metabolism in non-growing Campylobacter jejuni M1cam

Microorganism


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Hazard B, Fahy B, Gonzalez O, Savva G, Ahn-Jarvis J, Warren F, Lovegrove A, Dunn . (2022)

Loss of Starch Synthase IIIa changes starch molecular structure and granule morphology in grains of hexaploid bread wheat

Scientific Reports, 12, 10806


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