Gregory Wickham

Postgraduate Student

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Investigating the evolution of antimicrobial resistance


My PhD investigates how bacterial biofilms respond to biocidal challenge, and explores mechanisms of biocide-antibiotic cross-resistance in archetypal biofilm-forming pathogens. I am working closely with Procter & Gamble to develop an in vitro model predictive of biofilm behaviour for assessing efficacy and selective pressures of biocides.

I graduated from the University of Manchester in 2017 with a Master of Science degree in Medical Microbiology with Distinction. My thesis investigated mechanisms of fosfomycin heteroresistance among a cohort of multidrug-resistant Enterobacteriaceae causative of upper urinary tract infections. At undergraduate, I read Biology at the University of Chester and graduated with First Class Honours in 2016. My dissertation focused on validating a plate-based biocide sterilisation model and investigating variations in intrinsic susceptibility to benzalkonium chloride. It was graded highest in the department and subsequently published in Bioscience Horizons: The International Journal of Student Research.

From 2015 to 2017 I was employed by ALS Environmental alongside my studies. I worked in the method development laboratory performing gas chromatography-mass spectrometry analysis of biocides and plasticisers in wastewater effluent for the Chemical Investigation Programme 2, as part of the EU Water Framework Directive. Later, I became responsible for overseeing a microbiology laboratory involved in development of UKAS ISO 17025-accredited methods for monitoring pathogens and faecal indicator organisms in water treatment processes.

Trampari E., Webber M., Savva G., Martins L., Ravi A., Wickham G., Holden E.. (2020)

Exposure of Salmonella biofilms to sub-lethal concentrations of antibiotics rapidly selects for resistance but with collateral tradeoffs

npj biofilms and microbes

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Holden ER,Wickham GJ,Webber MA,Thomson NM,Trampari E. (2020)

Donor plasmids for phenotypically neutral chromosomal gene insertions in Enterobacteriaceae.

Microbiology (Reading, England)

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