Prof. John Wain

Group Leader

Contact via email

Bacterial diversity and tropical infections

Developing new technology to improve health care everywhere.

My career to date has alternated between service and academic microbiology in the UK, Nigeria and Vietnam. My current post, group leader at the Quadram Institute is focused on translational research on Microbes in the Food Chain.

I have a keen interest in the use of new technology in countries with developing economies.

In the past I have: designed and delivered a teaching programme for public health and clinical microbiology in Nigeria; setup microbiology research in Vietnam; established and run a research group at the Welcome Trust Sanger Institute; and directed for three years the HPA’s Gastrointestinal Reference Laboratory at Colindale (now Public Health England’s GBRU).

My research has described the influence on treatment outcome of reduced susceptibility to fluoroqinolones; linked antibiotic resistance and virulence in Salmonella; paved the way for the first Salmonella to be genome sequenced; produced high throughput genetic techniques for typing Salmonella (MLST); generated genomic methods for screening gene function and regulation in host adapted bacterial pathogens (TraDIS); and defined the parameters for the routine use of whole genome sequencing in public health microbiology.

Felgate H, Crossman LC, Gray E, Clifford R, Correia A, Dean R, Wain J, Langridge G. (2023)

Known mechanisms cannot account for a third of reduced susceptibility in non-aureus staphylococci

npj Antimicrobials and Resistance, 15

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Felgate H, Sethi D, Fuast K, Kiy C, Hartel C, Rupp J, Dean R, Tremlett C, Wain J, Langridge G, Clarke P, Page A, Webber . (2023)

Characterisation of neonatal Staphylococcus capitis NRCS-A isolates compared with non NRCS-A Staphylococcus capitis from neonates and adults.

Microbial Genomics, 9

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Stoakes E, Savva G, Coates R, Tejera N, Poolman M, Grant A, Wain J, Singh . (2022)

Substrate utilisation and energy metabolism in non-growing Campylobacter jejuni M1cam


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Diaz-Calvo T, Tejera-Hernandez N, McNamara I, Langridge G, Wain J, Poolman M, Singh . (2022)

Genome-Scale Metabolic Modelling Approach to Understand Metabolism of the Opportunistic Human Pathogen Staphylococcus epidermidis RP62A

Metabolites, 12(2)

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Wain J. (2022)

Quantitative bacterial counts in the bone marrow of Vietnamese patients with typhoid fever

Transactions of The Royal Society of Tropical Medicine and Hygiene,, 1-9

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Waters EV, Tucker LA, Ahmed JK, Wain J, Langridge G. (2022)

Impact of Salmonella genome rearrangement on gene expression.

Evolution letters

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Djeghout B, Bloomfield S, Rudder S, Elumogo N, Mather A, Wain J, Janecko . (2022)

Comparative genomics of Campylobacter jejuni from clinical campylobacteriosis stool specimens

Gut Pathogens

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Bloomfield SJ, Zomer AL, O'Grady J, Kay GL, Wain J, Janecko N, Palau R, Mather A. (2022)

Determination and quantification of microbial communities and antimicrobial resistance on food through host DNA-depleted metagenomics

Food Microbiology

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Genome sequencing SARS-CoV-2 plays a critical role in informing national and international COVID-19 public health responses

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