Prof. John Wain

Group Leader

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Bacterial diversity and tropical infections

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Biography

Recent Publications

Developing new technology to improve health care everywhere.

My career to date has alternated between service and academic microbiology in the UK, Nigeria and Vietnam. My current post, group leader at the Quadram Institute is focused on translational research on Microbes in the Food Chain.

I have a keen interest in the use of new technology in countries with developing economies.

In the past I have: designed and delivered a teaching programme for public health and clinical microbiology in Nigeria; setup microbiology research in Vietnam; established and run a research group at the Welcome Trust Sanger Institute; and directed for three years the HPA’s Gastrointestinal Reference Laboratory at Colindale (now Public Health England’s GBRU).

My research has described the influence on treatment outcome of reduced susceptibility to fluoroqinolones; linked antibiotic resistance and virulence in Salmonella; paved the way for the first Salmonella to be genome sequenced; produced high throughput genetic techniques for typing Salmonella (MLST); generated genomic methods for screening gene function and regulation in host adapted bacterial pathogens (TraDIS); and defined the parameters for the routine use of whole genome sequencing in public health microbiology.

Phu N. H., Day N. P. J., Tuan P. Q., Mai N. T. H., Chau T. T. H., Van Chuong L., Vinh H., Loc P. P., Sinh D. X., Hoa N. T. T., Waller D. J., Wain J., Jeyapant A., Watson J. A., Farrar J. J., Hien T. T., Parry C. M., White N. J.. (2020)

Concomitant bacteremia in adults with severe falciparum malaria.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Gold Lock

Wain J., Langridge G., Turner K., Yasir M.. (2020)

Emergence of Resistance to Fluoroquinolones and Third-Generation Cephalosporins in Salmonella Typhi in Lahore, Pakistan

medRxiv

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Nair S., Fookes M., Corton C., Thomson N. R., Wain J., Langridge G. C.. (2020)

Genetic markers in S. Paratyphi C reveal primary adaptation to pigs

Microorganisms, 8(5), 657

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Gold Lock

Tejera N,Crossman L,Pearson B,Stoakes E,Nasher F,Djeghout B,Poolman MG,Wain J,Singh D. (2020)

Genome-scale metabolic model driven design of a defined medium for Campylobacter jejuni M1cam

Frontiers in Microbiology, 11, 1072

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Ellis SJ,Crossman LC,McGrath CJ,Chattaway MA,Holken JM,Brett B,Bundey L,Kay GL,Wain J,Schuller S. (2020)

Identification and characterisation of enteroaggregative Escherichia coli subtypes associated with human disease

Scientifi Reports, Ahead of print, electronic

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Chessa D,Murgia M,Sias E,Deligios M,Mazzarello V,Fiamma M,Rovina D,Carenti G,Ganau G,Pintore E,Fiori M,Kay GL,Ponzeletti A,Cappuccinelli P,Kelvin DJ,Wain J,Rubino S. (2020)

Metagenomics and microscope revealed T. trichiura and other intestinal parasites in a cesspit of an Italian nineteenth century aristocratic palace.

Scientific reports

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Trotter AJ,Dean R,Whitehouse CE,Mikalsen J,Hill C,Brunton-Sim R,Kay GL,Shakokani M,Durst AZE,Wain J,McNamara I,O'Grady J. (2020)

Preliminary evaluation of a rapid lateral flow calprotectin test for the diagnosis of prosthetic joint infection.

Bone & joint research

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Charalampous T., Kay G. L., Richardson H., Aydin A., Baldan R., Jeanes C., Rae D., Grundy S., Turner D. J., Wain J., Leggett R. M., Livermore D. M., O'Grady J.. (2019)

Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection.

Nature Biotechnology, 37, 783-792

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