Dr Justin O'Grady

Group Leader

Contact via email

Rapid infectious disease and foodborne pathogen diagnosis/detection

I gained my B.Sc. in Microbiology, M.Sc. (Res) in infectious diseases molecular diagnostics and Ph.D. in molecular diagnosis of bacterial pathogens in food all at the National University of Ireland Galway (NUIG).  I stayed at NUIG for my first post-doc, continuing in food microbiology research. This was followed by a two-year stint in industry (Beckman Coulter) developing real-time PCR based molecular diagnostics assays for infectious diseases including Mycobacterium tuberculosis.

I then returned to academia, taking up a post-doc position at University College London on TB diagnostics. In January 2013 I was appointed Lecturer in Medical Microbiology at UEA and was promoted to Senior Lecturer in August 2016.

I joined the Quadram Institute as a Group Leader in April 2018 while maintaining my affiliation with the University of East Anglia (UEA). My research continues to focus on the molecular diagnosis of pathogens with the aim of translating this research broadly, in different sectors and diseases, to maximise community/patient benefit.

Key publications

Schmidt K, Mwaigwisya S, Crossman LC, Doumith M, Munroe D, Pires C, Khan AM, Woodford N, Saunders NJ, Wain J, O’Grady J (joint last and corresponding), Livermore DM. Identification of bacterial pathogens and antimicrobial resistance directly from clinical urines by nanopore-based metagenomic sequencing. J Antimicrob Chemother 2017 Jan;72(1):104-114.  doi: 10.1093/jac/dkw397

Jain M, Koren S, Miga KH, Quick J, Rand AC, Sasani TA, et al. Nanopore sequencing and assembly of a human genome with ultra-long reads. Nat Biotechnol. 2018. doi: 10.1038/nbt.4060

Burnham CD, Leeds J, Nordmann P, O’Grady J (all authors contributed equally), Patel J. Diagnosing antimicrobial resistance. Nat Rev Microbiol. 2017;15(11):697-703.  doi: 10.1038/nrmicro.2017.103

Ashton, P.M., Nair, S., Dallman, T., Rubino, S., Rabsch, W., Mwaigwisya, S., Wain, J., and O’Grady, J. MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island. Nature Biotech, 2015, 33(3):296-300. doi: 10.1038/nbt.3103

Bates M, O’Grady J (joint first author) et al: Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study. Lancet Infect Dis 2013, 13(1):36-42. doi: 10.1016/S1473-3099(12)70245-1

Foster-Nyarko E,Alikhan NF,Ravi A,Thilliez G,Thomson N,Baker D,Kay G,Antonio M,O J,Pallen MJ. (2020)

Genomic diversity of Escherichia coli isolates from non-human primates in the Gambia

Microbial Genomics, 6

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Trotter AJ,Dean R,Whitehouse CE,Mikalsen J,Hill C,Brunton-Sim R,Kay GL,Shakokani M,Durst AZE,Wain J,McNamara I,O'Grady J. (2020)

Preliminary evaluation of a rapid lateral flow calprotectin test for the diagnosis of prosthetic joint infection.

Bone & joint research

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Phelan J. E., O'Sullivan D. M., Machado D., Ramos J., Oppong Y. E. A., Campino S., O'Grady J., McNerney R., Hibberd M. L., Viveiros M., Huggett J. F., Clark T. G.. (2019)

Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.

Genome medicine, 11, 41

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Trotter A. J., Aydin A., Strinden M. J., O'Grady J.. (2019)

Recent and emerging technologies for the rapid diagnosis of infection and antimicrobial resistance.

Current Opinion in Microbiology, 51, 39-45

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Charalampous T., Kay G. L., Richardson H., Aydin A., Baldan R., Jeanes C., Rae D., Grundy S., Turner D. J., Wain J., Leggett R. M., Livermore D. M., O'Grady J.. (2019)

Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection.

Nature Biotechnology, 37, 783-792

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O'Grady J.. (2019)

A powerful, non-invasive test to rule out infection.

Nature microbiology, 4, 554-555

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Schmidt K., Stanley K. K., Hale R., Wain J., Wain J., O'Grady J., Livermore D. M.. (2018)

Evaluation of multiplex tandem PCR (MT-PCR) assays for the detection of bacterial resistance genes among Enterobacteriaceae in clinical urines.

The Journal of antimicrobial chemotherapy

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Related News

Current Vacancies

Applications Close: 28 January 2021

Research Scientist (Infection Metagenomics)

Applications are invited for a Research Scientist to join the laboratory of Dr Justin O’Grady at Quadram Institute Bioscience...