Dr Laura Vaux
Glycobiology of host-microbe interactions in the gut
I was previously based at the University of East Anglia, where I obtained a PhD from the Norwich Medical school, studying autophagy and innate immunity.
In 2015 I joined Dr Carmen Pin’s group at the Quadram Institute Bioscience where I used mouse models to study multicolour lineage tracing of intestinal stem cells under homeostatic and inflammatory conditions both in vitro and in vivo with the use of intestinal organoid cultures. The aim of this work was to use both in vivo experimental data combined with mathematical modelling, to understand what drives the proliferation and migration of the intestinal epithelium along the crypt villus axis.
Zhou Z, Cottam E, Whelband M, Vaux L, Wileman T. (2012). Xenophagy and the removal of intracellular pathogens – Evolving Immunity. Biochemist. April; 34 (2): 20-23.2.
Cottam EM, Maier HJ, Manifava M, Vaux LC, Chandra-Schoenfelder P, Gerner W, Britton P, Ktistakis NT, Wileman T. (2011). Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate. Autophagy. Nov;7(11):1335-47.
Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium
Journal of the Royal Society Interface, 15, Issue 145
Host-microbe interaction in the gastrointestinal tract.