Dr Lee Kellingray

Researcher

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Translational microbiome

View Arjan Narbad's group

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Biography

Recent Publications

I obtained a first class degree in Microbiology at the University of East Anglia in 2011, and joined the Quadram Institute Science in the same year to do a PhD looking at the effects of Brassica vegetables on the human gut microbiota. Following my PhD I joined the Translational Microbiome group as a research scientist to work with Professor Arjan Narbad to examine how pathogenic bacteria interact with the human gut microbiota, and investigate the potential of next generation sequencing as a clinical diagnostic tool.

I am currently involved in a successful collaboration with the Norfolk and Norwich University Hospital providing bacteriotherapy to patients with recurrent Clostridium difficile infection. In addition to this I am using in vitro colon models and ¹H NMR to examine the effects of gut pathogens, such as Salmonella typhimurium, on the gut microbiota through metagenomic and metabolomic analyses.

My current interests are focused on the role of the gut microbiota in health, specifically host-microbe and microbe-microbe interactions, and how this research can be translated to improved health outcomes for the general public.

Connell E, Blokker B, Kellingray L, Le Gall, Philo M, Pontifex MG, Narbad A, Müller M, Vauzour . (2024)

Refined diet consumption increases neuroinflammatory signalling through bile acid dysmetabolism.

Nutritional neuroscience

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Gold Lock

Shehata E, Day-Walsh P, Kellingray L, Narbad A, Kroon P. (2023)

Spontaneous and Microbiota-Driven Degradation of Anthocyanins in an In Vitro Human Colon Model.

Molecular nutrition & food research

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Gold Lock

Day-Walsh P,Shehata E,Saha S,Savva GM,Nemeckova B,Speranza J,Kellingray L,Narbad A,Kroon PA. (2021)

The use of an in-vitro batch fermentation (human colon) model for investigating mechanisms of TMA production from choline, L-carnitine and related precursors by the human gut microbiota.

European journal of nutrition

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Gold Lock

Parmanand B,Watson M,Boland KJ,Ramamurthy N,Wharton V,Morovat A,Lund EK,Collier J,Le Gall,Kellingray L,Fairweather-Tait S,Cobbold JF,Narbad A,Ryan JD. (2020)

Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis.

JHEP reports : innovation in hepatology

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Gold Lock

Kellingray L,Le Gall,Doleman JF,Narbad A,Mithen RF. (2020)

Effects of in vitro metabolism of a broccoli leachate, glucosinolates and S-methylcysteine sulphoxide on the human faecal microbiome.

European journal of nutrition

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Gold Lock

Petropoulou K,Salt LJ,Edwards CH,Warren FJ,Garcia-Perez I,Chambers ES,Alshaalan R,Khatib M,Perez-Moral N,Gotts KL,Kellingray L,Stanley R,Koev T,Khimyak YZ,Narbad A,Penney N,Serrano-Contreras JI,Charalambides MN,Blanco JM,Seoane RC,McDonald JAK,Marchesi JR,Holmes E,Godsland IF,Morrison DJ,Preston T,Domoney C,Wilde PJ,Frost GS. (2020)

A natural mutation in Pisum sativum L. (pea) alters starch assembly and improves glucose homeostasis in humans

Nature Food, 1, 693704

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Gold Lock

Kellingray L,Le Gall G,Doleman JF,Narbad A,Mithen RF. (2020)

Effects of in-vitro metabolism of a broccoli-leachate, glucosinolates, and S-methylcysteine sulphoxide on the human faecal microbiome

European Journal of Nutrition

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Gold Lock

Yu L,Duan H,Kellingray L,Cen S,Tian F,Zhao J,Zhang H,Gall GL,Mayer MJ,Zhai Q,Chen W,Narbad A. (2020)

Lactobacillus plantarum-Mediated Regulation of Dietary Aluminum Induces Changes in the Human Gut Microbiota: an In Vitro Colonic Fermentation Study.

Probiotics and antimicrobial proteins