Dr Lee Kellingray


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Translational microbiome


I obtained a first class degree in Microbiology at the University of East Anglia in 2011, and joined the Quadram Institute Science in the same year to do a PhD looking at the effects of Brassica vegetables on the human gut microbiota. Following my PhD I joined the Translational Microbiome group as a research scientist to work with Professor Arjan Narbad to examine how pathogenic bacteria interact with the human gut microbiota, and investigate the potential of next generation sequencing as a clinical diagnostic tool.

I am currently involved in a successful collaboration with the Norfolk and Norwich University Hospital providing bacteriotherapy to patients with recurrent Clostridium difficile infection. In addition to this I am using in vitro colon models and 1H NMR to examine the effects of gut pathogens, such as Salmonella typhimurium, on the gut microbiota through metagenomic and metabolomic analyses.

My current interests are focused on the role of the gut microbiota in health, specifically host-microbe and microbe-microbe interactions, and how this research can be translated to improved health outcomes for the general public.

Yu L,Duan H,Kellingray L,Cen S,Tian F,Zhao J,Zhang H,Gall GL,Mayer MJ,Zhai Q,Chen W,Narbad A. (2020)

Lactobacillus plantarum-Mediated Regulation of Dietary Aluminum Induces Changes in the Human Gut Microbiota: an In Vitro Colonic Fermentation Study.

Probiotics and antimicrobial proteins

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Petropoulou K,Salt LJ,Edwards CH,Warren FJ,Garcia-Perez I,Chambers ES,Alshaalan R,Khatib M,Perez-Moral N,Gotts KL,Kellingray L,Stanley R,Koev T,Khimyak YZ,Narbad A,Penney N,Serrano-Contreras JI,Charalambides MN,Blanco JM,Seoane RC,McDonald JAK,Marchesi JR,Holmes E,Godsland IF,Morrison DJ,Preston T,Domoney C,Wilde PJ,Frost GS. (2020)

A natural mutation in Pisum sativum L. (pea) alters starch assembly and improves glucose homeostasis in humans

Nature Food, 1, 693704

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Parmanand B,Watson M,Boland KJ,Ramamurthy N,Wharton V,Morovat A,Lund EK,Collier J,Le Gall,Kellingray L,Fairweather-Tait S,Cobbold JF,Narbad A,Ryan JD. (2020)

Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis.

JHEP reports : innovation in hepatology

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Parmanand B., Kellingray L., Le Gall G., Basit A., Fairweather S., Narbad A.. (2019)

A decrease in iron availability to human gut microbiome reduces the growth ofpotentially pathogenic gut bacteria; an in vitro colonic fermentation study

Journal of Nutritional Biochemistry, 67, 20-27

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Tran T. T. T., Corsini S., Kellingray L., Hegarty C., Le Gall G., Narbad A., Müller M., Tejera N., O'Toole P. W., Minihane A. M., Vauzour D.. (2019)

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology.

FASEB Journal, fj201900071R

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