Prof. Lindsay Hall

Group Leader

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Early life microbiota-host interactions

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I’ve been a Group Leader at Quadram since 2015 and I’m also a Wellcome Investigator. I am also Chair of Microbiome Research, Institute of Microbiology and Infection at the University of Birmingham. Our teams’ research focus involves defining microbe/microbiota interactions during the early life developmental window.

I obtained a BSc in Microbiology from the University of Glasgow, a PhD in Microbiology and Immunology from the University of Cambridge (Wellcome Trust Sanger Institute), and was a postdoctoral fellow at University College Cork, Ireland (APC Microbiome Institute). I returned to the UK to take up a Senior Lectureship at the University of East Anglia before my move to Quadram.

 


Key publications

Alcon-Giner C, Dalby MJ, Caim S, Ketskemety J, Shaw A, Sim K, Lawson M, Kiu R, Leclaire C, Chalklen L, Kujawska M, Mitra D, Fardus-Reid F, Belteki, G, McColl K, Swann JR, Kroll JS, Clarke P, Hall LJ.: “Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome: an observational study”. Cell Reports Medicine. 2020.

Lawson MAE/O’Neill IJ, Kujawska M, Wijeyesekera A, Flegg Z, Chalklen L, Hall LJ.: “Breast-milk derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem”. ISME J. 2020; 14(2):635-648.

Alcon-Giner C/Leggett RM, Heavens D, Caim S, Brook TC, Kujawska M, Hoyles L, Clarke P, Clark MD/Hall LJ.: “Rapid MinION profiling of preterm microbiota and antimicrobial resistant pathogens”. Nature Microbiology. 2019.

Hughes KR, Harnisch L, Alcon-Giner C, Mitra S, Wright CJ, Ketskemety J, van Sinderen D, Watson AJM, and Hall LJ.:”Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner”. Open Biology. 2017; doi.org/10.1098/rsob.160155.

Hall LJ/Fanning S, Cronin M, Zomer A, MacSharry J, Goulding D, O’Connell-Motherway M, Shanahan F, Nally K, Dougan G, van Sinderen D.: “Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation & pathogen protection”. PNAS. 2012; 109(6):2108-13.

Lamberte L, Darby E, Kie R, Moran R, Acuna-Gonzalez A, Sim K, Shaw A, Kroll S, Belteki G, Clarke P, Felgate H, Webber M, Rowe W, Hall L, Van Schaik W. (2025)

Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut

Gut Microbes, Gut Microbes KGMI


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Samarra A, Renwick S, Arzamasov AA, Rodionov DA, Spann K, Cabrera-Rubio R, Acuna-Gonzalez A, Martínez-Costa C, Hall L, Segata N, Osterman AL, Bode L, Collado M. (2025)

Human milk oligosaccharide metabolism and antibiotic resistance in early gut colonizers: insights from bifidobacteria and lactobacilli in the maternal-infant microbiome.

Gut microbes


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Dawson SJT, Shibu P, Garnett S, Newberry F, Brook TC, Tijani T, Kujawska M, Hall LJ, McCartney AL, Negus D, Hoyles L. (2025)

Weberviruses are gut-associated phages that infect Klebsiella spp.

FEMS microbiology ecology


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Metris A, Walker AW, Showering A, Doolan A, McBain AJ, Ampatzoglou A, Murphy B, O'Neill C, Shortt C, Darby EM, Aldis G, Hillebrand GG, Brown HL, Browne HP, Tiesman JP, Leng J, Lahti L, Jakubovics NS, Hasselwander O, Finn RD, Klamert S, Korcsmaros T, Hall LJ. (2025)

Assessing the safety of microbiome perturbations.

Microbial genomics


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Kaktcham PM, Kujawska M, Kouam EMF, Piame LT, Tientcheu MLT, Mueller J, Felsl A, Truppel BA, Ngoufack FZ, Hall LJ. (2025)

Genomic insights into the beneficial potential of Bifidobacterium and Enterococcus strains isolated from Cameroonian infants.

Microbial genomics


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Jain V, Alexander EC, Burford C, Davenport M, Dalby MJ, Hall LJ, Dhawan A. (2025)

Ethanol in biliary atresia.

Archives of disease in childhood


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