Prof. Lindsay Hall

Group Leader

Contact via email

Early life microbiota-host interactions

I’ve been a Group Leader at Quadram since 2015 and I’m also a Wellcome Investigator. I am also Chair of Microbiome Research, Institute of Microbiology and Infection at the University of Birmingham. Our teams’ research focus involves defining microbe/microbiota interactions during the early life developmental window.

I obtained a BSc in Microbiology from the University of Glasgow, a PhD in Microbiology and Immunology from the University of Cambridge (Wellcome Trust Sanger Institute), and was a postdoctoral fellow at University College Cork, Ireland (APC Microbiome Institute). I returned to the UK to take up a Senior Lectureship at the University of East Anglia before my move to Quadram.

 


Key publications

Alcon-Giner C, Dalby MJ, Caim S, Ketskemety J, Shaw A, Sim K, Lawson M, Kiu R, Leclaire C, Chalklen L, Kujawska M, Mitra D, Fardus-Reid F, Belteki, G, McColl K, Swann JR, Kroll JS, Clarke P, Hall LJ.: “Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome: an observational study”. Cell Reports Medicine. 2020.

Lawson MAE/O’Neill IJ, Kujawska M, Wijeyesekera A, Flegg Z, Chalklen L, Hall LJ.: “Breast-milk derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem”. ISME J. 2020; 14(2):635-648.

Alcon-Giner C/Leggett RM, Heavens D, Caim S, Brook TC, Kujawska M, Hoyles L, Clarke P, Clark MD/Hall LJ.: “Rapid MinION profiling of preterm microbiota and antimicrobial resistant pathogens”. Nature Microbiology. 2019.

Hughes KR, Harnisch L, Alcon-Giner C, Mitra S, Wright CJ, Ketskemety J, van Sinderen D, Watson AJM, and Hall LJ.:”Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner”. Open Biology. 2017; doi.org/10.1098/rsob.160155.

Hall LJ/Fanning S, Cronin M, Zomer A, MacSharry J, Goulding D, O’Connell-Motherway M, Shanahan F, Nally K, Dougan G, van Sinderen D.: “Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation & pathogen protection”. PNAS. 2012; 109(6):2108-13.

Gooch HCC, Labedan M, Hall LJ, Maxwell . (2024)

Transplanting human infant gut microbiome species into Galleria mellonella.

BMC research notes


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Elek C, Brown T, Le Viet T, Evans R, Baker D, Telatin A, Tiwari S, Al-Khanaq H, Thilliez G, Kingsley R, Hall L, Webber M, Adriaenssens . (2023)

A hybrid and poly-polish workflow for the complete and accurate assembly of phage genomes: a case study of ten przondoviruses

Microbial Genomics, 9


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Serghiou IR, Baker D, Evans R, Dalby MJ, Kiu R, Trampari E, Phillips S, Watt R, Atkinson T, Murphy B, Hall LJ, Webber M. (2023)

An efficient method for high molecular weight bacterial DNA extraction suitable for shotgun metagenomics from skin swabs.

Microbial genomics


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Teng NMY, Kiu R, Evans R, Baker DJ, Zenner C, Robinson SD, Hall L. (2023)

Allocoprobacillus halotolerans gen. nov., sp. nov and Coprobacter tertius sp. nov., isolated from human gut microbiota.

International journal of systematic and evolutionary microbiology


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Kiu R, Shaw AG, Sim K, Acuna-Gonzalez A, Price CA, Bedwell H, Dreger SA, Fowler WJ, Cornwell E, Pickard D, Belteki G, Malsom J, Phillips S, Young GR, Schofield Z, Alcon-Giner C, Berrington JE, Stewart CJ, Dougan G, Clarke P, Douce G, Robinson SD, Kroll JS, Hall L. (2023)

Particular genomic and virulence traits associated with preterm infant-derived toxigenic Clostridium perfringens strains.

Nature microbiology


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Momo Kadia, Otiti MI, Ramsteijn AS, Sow D, Faye B, Heffernan C, Hall LJ, Webster JP, Walker AW, Allen . (2023)

Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth.

Nutrition reviews


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Acuna-Gonzalez A, Kujawska M, Mayada Y, Atkinson T, Grundy S, Hutchison A, Tremlett C, Clarke P, Hall . (2023)

Bifidobacterium bacteraemia is rare with routine probiotics use in preterm infants: A further case report with literature review

Anaerobe


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