Prof. Lindsay Hall

Group Leader

Contact via email

Early life microbiota-host interactions

I’ve been a Group Leader at Quadram since 2015 and I’m also a Wellcome Investigator. Recently (2020) I took up a new position at the Technical University Munich, Germany, where I am Chair of Intestinal Microbiome. Our teams’ research focus involves defining microbe/microbiota interactions during the early life developmental window.

I obtained a BSc in Microbiology from the University of Glasgow, a PhD in Microbiology and Immunology from the University of Cambridge (Wellcome Trust Sanger Institute), and was a postdoctoral fellow at University College Cork, Ireland (APC Microbiome Institute). I returned to the UK to take up a Senior Lectureship at the University of East Anglia before my move to Quadram.


Key publications

Alcon-Giner C, Dalby MJ, Caim S, Ketskemety J, Shaw A, Sim K, Lawson M, Kiu R, Leclaire C, Chalklen L, Kujawska M, Mitra D, Fardus-Reid F, Belteki, G, McColl K, Swann JR, Kroll JS, Clarke P, Hall LJ.: “Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome: an observational study”. Cell Reports Medicine. 2020.

Lawson MAE/O’Neill IJ, Kujawska M, Wijeyesekera A, Flegg Z, Chalklen L, Hall LJ.: “Breast-milk derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem”. ISME J. 2020; 14(2):635-648.

Alcon-Giner C/Leggett RM, Heavens D, Caim S, Brook TC, Kujawska M, Hoyles L, Clarke P, Clark MD/Hall LJ.: “Rapid MinION profiling of preterm microbiota and antimicrobial resistant pathogens”. Nature Microbiology. 2019.

Hughes KR, Harnisch L, Alcon-Giner C, Mitra S, Wright CJ, Ketskemety J, van Sinderen D, Watson AJM, and Hall LJ.:”Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner”. Open Biology. 2017;

Hall LJ/Fanning S, Cronin M, Zomer A, MacSharry J, Goulding D, O’Connell-Motherway M, Shanahan F, Nally K, Dougan G, van Sinderen D.: “Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation & pathogen protection”. PNAS. 2012; 109(6):2108-13.

Teng N,Price C,Mckee A,Hall L,Robinson STEPHEN. (2021)

Exploring the impact of gut microbiota and diet on breast cancer risk and progression

International journal of cancer

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Henneke P,Kierdorf K,Hall LJ,Sperandio M,Hornef M. (2021)

Perinatal development of innate immune topology.


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Greenhough B., Read C. J., Lorimer J., Lezaun J., McLeod C., Benezra A., Bloomfield S., Brown T., DAcquisto F., Clinch M., Dumitriu A., Evans J., Fawcett N., Fortané N., Hall L. J., Herrera C. E. G., Hodgetts T., Johnson K. V. A., Kirchhelle C., Krzywoszynska A., Lambert H., Monaghan T., Nading A., Nerlich B., Singer A., Szymanski E., Wills J. ... (2020)

Setting the agenda for social science research on the human microbiome

Palgrave Communications , 6, 18

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Hughes K. R., Schofield Z., Dalby M. J., Caim S., Chalklen L., Bernuzzi F., Alcon C., Le Gall G., Watson A. J. M., Hall L. J.. (2020)

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding.

FASEB Journal

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Püngel D., Treveil A., Dalby M. J., Caim S., Colquhoun I. J., Booth C., Ketskemety J., Korcsmaros T., van Sinderen D., Lawson M. A., Hall L. J.. (2020)

Bifidobacterium breve UCC2003 Exopolysaccharide Modulates the Early Life Microbiota by Acting as a Potential Dietary Substrate.

Nutrients, 12

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