Dr Lindsay Hall

Group Leader

Contact via email

Early life microbiota-host interactions


I qualified with a BSc (Hons) in Microbiology from the University of Glasgow in 2003. I then went on to study for a PhD in Microbiology and Immunology at the Wellcome Trust Sanger Institute (University of Cambridge) under the supervision of Prof Gordon Dougan.

My thesis focused on designing and creating mucosal vaccines against Mycobacterium tuberculosis and characterising mucosal immune responses (specifically Natural Killer, [NK] cells) induced after oral and intranasal immunisations. My PhD was part funded through the EU sixth framework programme entitled Mucosal Vaccines Against Poverty Related Diseases (MUVAPRED).

In 2007 I took up a postdoctoral position at the APC Microbiome Institute, University College Cork in Ireland. During my time in Cork, I moved into a new mucosal immunology area focused on intestinal inflammatory disorders. My research utilised experimental Ulcerative colitis and enteric pathogen models to understand the protective role of early mucosal immune responses (including NK cells) during acute intestinal inflammation. In Cork, I also started to work on the bacterial communities that inhabit the gut, termed the microbiota, specifically understanding the role of individual members (i.e. Bifidobacterium) and their products (exopolysaccharide capsules) in modulating the critical commensal-host interaction.

I returned to the UK in 2011 to take up a lecturing and Principle Investigator position within the Norwich Medical School, University of East Anglia.  In 2013 I was awarded a Wellcome Trust Investigator Award to study the role of early life gut microbiota in colonisation resistance development and was promoted to senior lecturer in 2014. In 2015 I moved to the Institute of Food Research as the Microbiome Group Leader and my team studies the early life microbiota in health and disease.

Key publications

Hughes KR, Harnisch L, Alcon-Giner C, Mitra S, Wright CJ, Ketskemety J, van Sinderen D, Watson AJM, and Hall LJ. Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner. Open Biology. 2017. DOI: 10.1098/rsob.160155

Hall LJ, Murphy CT, Quinlan A, Hurley G, Shanahan F, Nally K, Melgar S. Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor. Mucosal Immunol. 2013;6(5):1016-26

Hall LJ, Murphy CT, Quinlan A, Hurley G, Shanahan F, Nally K, Melgar S. Natural Killer cells protect against mucosal and systemic infection with the enteric pathogen Citrobacter rodentium. Infect. Immun. 2013;81(2):460-9

Hall LJ/Fanning S, Cronin M, Zomer A, MacSharry J, Goulding D, O’Connell-Motherway M, Shanahan F, Nally K, Dougan G, van Sinderen D. Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation & pathogen protection. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2108-13.

Hall LJ/ Jansen AM, , Clare S, Goulding D, Holt KE, Grant AJ, Mastroeni P, Dougan G, Kingsley RA. A Salmonella Typhimurium-Typhi genomic chimera: A murine-typhoid model to study Vi polysaccharide capsule function. PLoS Pathogens. 2011 Jul;7(7):e1002131.

Jones E., Matthews Z., Gul L., Sudhakar P., Treveil A., Divekar D., Buck J., Wrzesinski T., Jefferson M., Armstrong S., Hall L., Watson A., Carding S., Haerty W., Di Palma F., Mayer U., Powell P., Hautefort I., Wileman T., Korcsmaros T.. (2019)

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Disease Models and Mechanisms

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Rowe W. P., Carrieri A. P., Alcon C., Caim S., Shaw A., Sim K., Kroll J. S., Hall L. J., Pyzer-Knapp E. O., Winn M. D.. (2019)

Streaming histogram sketching for rapid microbiome analytics.

Microbiome, 7, 40

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Hall L. J., Sultan A., Mallen C., Muller S., Hider S., Scott I., Helliwell T.. (2019)

Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study

BMC Medicine, 17, 154

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Scott N. A., Andrusaite A., Andersen P., Lawson M., Alcon C., Leclaire C., Caim S., Le Gall G., Shaw T., Connolly J. P. R., Roe A. J., Wessel H., Bravo-Blas A., Thomson C. A., Kästele V., Wang P., Peterson D. A., Bancroft A., Li X., Grencis R., Mowat A. M., Hall L. J., Travis M. A., Milling S. W. F., Mann E. R.. (2018)

Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis.

Science translational medicine, 10

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Hughes K. R., Harnisch L. C., Alcon C., Mitra S., Wright C. J., Ketskemety J., van Sinderen D., Watson A. J., Hall L. J.. (2017)

Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner.

Open biology, 7, 160155

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Kiu R., Caim S., Alcon C., Belteki G., Clarke P., Pickard D., Dougan G., Hall L.. (2017)

Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights

Genome Biology and Evolution, 9, 2707-2714

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