I got my B.Sc. in Pharmaceutical Sciences from the Faculty of Pharmacy, Ain Shams University, Cairo, Egypt, in July 2008. I was awarded my M.Sc. degree in August 2013 and my Ph.D. degree in March 2021, both in Pharmaceutical Sciences from the Department of Pharmacognosy and Phytochemistry at Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. I joined the Quadram Institute as a visiting postdoctoral scientist in the Kroon Group in January 2023.

At the Quadram Institute, I am engaged in cutting-edge studies combining analytical chemistry and gut microbiome research. My research focuses on studying the role of gut microbiota in determining the bioavailability and metabolism of polyphenols using in vitro fermentation colon model experiments, including assessing the influence of colonic pH on gut microbial metabolism. Other activities include metabolic profiling of crude plant extracts utilising advanced Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and quantitative metabolomic analysis of biological samples to evaluate the bioavailability of polyphenols. My work aims to advance the understanding of polyphenol metabolism and their interactions with the gut microbiome.

Key publications

How to maintain a healthy gut microbiome in 2024, The conversation, Published: January 8, 2024

Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking Gamal El-Din MI, Mantawy EM, Said RS, Fahmy NM, Fayez S, Shahin MI, Nasr M, Elissawy AM, Singab ANB. Archiv der Pharmazie, 2024. doi 10.1002/ardp.202400392

Enhanced Expression of p53 and Suppression of PI3K/Akt/mTOR by Three Red Sea Algal Extracts: Insights on Their Composition by LC-MS-Based Metabolic Profiling and Molecular Networking. Fahmy, NM, Gamal El-Din MI, Salem, MM, Rashedy, SH, Lee, GS, Jang, YS, Kim, KH, Kim, CS, El-Shazly, M, Fayez, S, Marine Drugs, 2023, 21, 404. doi 10.3390/md21070404

Comparative LC–LTQ–MS–MS analysis of the leaf extracts of Lantana camara and Lantana montevidensis growing in Egypt with insights into their antioxidant, anti-inflammatory, and cytotoxic activities .Gamal El-Din MI, Fahmy NM, Wu F, Salem MM, Khattab OM, El-Seedi HR, Korinek M, Hwang T.-L., Osman AK; El-Shazly M; et al., Plants 2022, 11(13),1699. 10.3390/plants11131699

New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using alcohol-induced gastric ulcer model in rats. Gamal El-Din MI, Youssef FS, Ashour M, Eldahshan O, Singab AB. Food & Function. 2020; 11 (3), 1958-1965. doi 10.1039/C9FO02800E

Comparative analysis of volatile constituents of Pachira aquatica Aubl. and Pachira glabra Pasq., their anti-mycobacterial and anti-Helicobacter pylori Activities
Gamal El-Din MI, Youssef FS, Ashour ML, Eldahshan OA, Singab ANB, Journal of Essential Oil-Bearing Plants 2018; 21 (6), 1550-1567. https://doi.org/10.1080/0972060X.2019.1571950