Dr Matthew Dalby


Contact via email

Early life microbiota-host interactions

My current project work involves analysing the results of a trial investigating how a Bifidobacterium probiotic can shape the developing infant gut microbiota in premature babies. These infants are vulnerable to severe infections as their gut becomes colonised by bacteria in the hospital environment. This project is looking at how early colonisation with Bifidobacterium can alter this process to improve premature infant health.

I have a BSc in Biological Sciences from the University of Edinburgh followed by MSc in Molecular Nutrition at the University of Aberdeen where I went on to do a PhD studying how the bacteria in the gut can interact with their host to influence bodyweight. I began working at the Hall lab in May 2018 since when I have been using the bioinformatics skills from my PhD to study the infant gut.

Key Publications

Dalby MJ et al. (2018) Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N. Scientific Reports. DOI: 10.1038/s41598-018-33928-4

Dalby MJ et al. (2017) Dietary uncoupling of gut microbiota and energy harvesting from obesity and glucose tolerance in mice. Cell Reports. DOI: 10.1016/j.celrep.2017.10.056

Serghiou IR, Baker D, Evans R, Dalby MJ, Kiu R, Trampari E, Phillips S, Watt R, Atkinson T, Murphy B, Hall LJ, Webber M. (2023)

An efficient method for high molecular weight bacterial DNA extraction suitable for shotgun metagenomics from skin swabs.

Microbial genomics

View Publication

Neumann CJ, Mahnert A, Kumpitsch C, Kiu R, Dalby MJ, Kujawska M, Madl T, Kurath-Koller S, Urlesberger B, Resch B, Hall LJ, Moissl-Eichinger . (2023)

Clinical NEC prevention practices drive different microbiome profiles and functional responses in the preterm intestine.

Nature communications

View Publication

Lopez-Tello J, Schofield Z, Kiu R, Dalby MJ, van Sinderen, Le Gall, Sferruzzi-Perri AN, Hall L. (2022)

Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice.

Cellular and molecular life sciences : CMLS

View Publication

Mckee A, Kirkup B, Madgwick M, Fowler W, Price C, Dreger S, Ansorge R, Makin K, Caim S, Le Gall G, Pavely J, Leclaire C, Dalby M, Alcon-Giner C, Andrusaite A, Feng TY, Di Modica M, Triulzi T, Tagliabue E, Milling S, Weilbaecher K, Rutkowski M, Korcsmaros T, Hall L, Robinson S. (2021)

Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumour growth


View Publication

Hughes K. R., Schofield Z., Dalby M. J., Caim S., Chalklen L., Bernuzzi F., Alcon C., Le Gall G., Watson A. J. M., Hall L. J.. (2020)

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding.

FASEB Journal

View Publication

P√ľngel D., Treveil A., Dalby M. J., Caim S., Colquhoun I. J., Booth C., Ketskemety J., Korcsmaros T., van Sinderen D., Lawson M. A., Hall L. J.. (2020)

Bifidobacterium breve UCC2003 Exopolysaccharide Modulates the Early Life Microbiota by Acting as a Potential Dietary Substrate.

Nutrients, 12

View Publication

Alcon C,Dalby MJ,Caim S,Ketskemety J,Shaw A,Sim K,Lawson MAE,Kiu R,Leclaire C,Chalklen L,Kujawska M,Mitra S,Fardus-Reid F,Belteki G,McColl K,Swann JR,Kroll JS,Clarke P,Hall LJ. (2020)

Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study.

Cell reports. Medicine

View Publication

Related Case Studies

A small baby on a yellow blanket in an incubator connected to medical equipment

Targeting a life-threatening gut condition in preterm babies

Related News