Dr Nathalie Juge

Research Leader

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I have led a Research Team, since 2008, that investigates the glycobiology of host-microbe interactions in the gut.

My previous research focused on the structure-function relationships of plant and microbial glycoenzymes and their potential biotechnological application (stemming from my PhD project on barley amylases in Biochemistry-Molecular Biology of Nutrition, Marseille University, France in 1993) and successive postdoctoral positions on fungal glucoamylases at the Carlsberg Research Institute (EMBO and EU-funding) and Institute of Food Research (Marie-Curie fellowship).

After obtaining a lectureship position in Marseille University in Biochemistry and Molecular Biology (in 1997), I led a research Group on Glycosidases in Marseille (1997-1999) and in Norwich (1999-2004) while on secondment at IFR. I put together and coordinated an EU FP5 project on glycosidases and glycosidase inhibitors in food processing (1999-2003),.I obtained a post-doctoral qualification “Habilitation à Diriger les Recherches” in Marseille back in 2005.

Today my team studies the molecular mechanisms of gut bacteria/mucin interactions in health and disease.


Key Publications

Tailford L. E., Owen C. D., Walshaw J., Crost E. H., Hardy-Goddard J., Le Gall G., de Vos W. M., Taylor G. L. and Juge N.* Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat. Commun. 6 (2015) 7624.

Kober, O.I., Ahl, D., Pin, C., Holm, L., Carding, S.R. and Juge, N.* γδ T-cell-deficient mice show alterations in mucin expression, glycosylation and goblet cells but maintain an intact mucus layer. Am. J. Physiol. Gastrointest. Liver Physiol. 306 (2014) G582-93.

Etzold, S., Kober, O.I, Mackenzie, D.A., Tailford, L.E., Gunning, A.P., Walshaw, J., Hemmings, A.M. and Juge, N.* Structural basis for adaptation of lactobacilli to gastrointestinal mucus. Environ. Microbiol. 16 (2014) 888-903.

Crost E. H., Tailford L. E., Le Gall G., Fons M., Henrissat B., and  Juge N. * Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent. PloS One 8 (2013) e76341.

MacKenzie, D.A., Tailford, L.E., Hemmings, A.M and Juge, N.* Crystal structure of a mucus binding protein repeat reveals an unexpected functional immunoglobulin binding activity. J. Biol. Chem. 284 (2009) 32444-53.

Bene K. P., Kavanaugh D. W., Leclaire C., Gunning A. P., MacKenzie D. A., Wittmann W., Young I. D., Kawasaki N., Rajnavolgyi E., Juge N.. (2017)

Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors

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Monestier M., Latousakis D., Bell A., Tribolo S., Tailford L. E., Colquhoun I. J., Le Gall G., Yu H., Chen X., Rejzek M., Dedola S., Field R. A., Juge N.. (2017)

Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives.

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Crost E. H., Tailford L. E., Monestier M., Swarbreck D., Henrissat B., Crossman L. C., Juge N.. (2016)

The mucin-degradation strategy of Ruminococcus gnavus: The importance of intramolecular trans-sialidases.

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Walsham A., MacKenzie D., Cook V., Wemyss-Holden S., Hews C., Juge N., Schüller S.. (2016)

Lactobacillus reuteri Inhibition of Enteropathogenic Escherichia coli Adherence to Human Intestinal Epithelium

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Wegmann U., MacKenzie D. A., Zheng J., Goesmann A., Roos S., Swarbreck D., Walter J., Crossman L., Juge N.. (2015)

The pan-genome of Lactobacillus reuteri strains originating from the pig gastrointestinal tract”

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