Prof. Nathalie Juge

Research Leader

Contact via email

Glycobiology of host-microbe interactions in the gut

Links/websites:

I have led a Research Team, since 2008, that investigates the glycobiology of host-microbe interactions in the gut.

My previous research focused on the structure-function relationships of plant and microbial glycoenzymes and their potential biotechnological application (stemming from my PhD project on barley amylases in Biochemistry-Molecular Biology of Nutrition, Marseille University, France in 1993) and successive postdoctoral positions on fungal glucoamylases at the Carlsberg Research Institute (EMBO and EU-funding) and Institute of Food Research (Marie-Curie fellowship).

After obtaining a lectureship position in Marseille University in Biochemistry and Molecular Biology (in 1997), I led a research Group on Glycosidases in Marseille (1997-1999) and in Norwich (1999-2004) while on secondment at IFR. I put together and coordinated an EU FP5 project on glycosidases and glycosidase inhibitors in food processing (1999-2003),.I obtained a post-doctoral qualification “Habilitation à Diriger les Recherches” in Marseille back in 2005.

Today my team studies the molecular mechanisms of gut bacteria/mucin interactions in health and disease.


Key Publications

Tailford L. E., Owen C. D., Walshaw J., Crost E. H., Hardy-Goddard J., Le Gall G., de Vos W. M., Taylor G. L. and Juge N.* Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat. Commun. 6 (2015) 7624.

Kober, O.I., Ahl, D., Pin, C., Holm, L., Carding, S.R. and Juge, N.* γδ T-cell-deficient mice show alterations in mucin expression, glycosylation and goblet cells but maintain an intact mucus layer. Am. J. Physiol. Gastrointest. Liver Physiol. 306 (2014) G582-93.

Etzold, S., Kober, O.I, Mackenzie, D.A., Tailford, L.E., Gunning, A.P., Walshaw, J., Hemmings, A.M. and Juge, N.* Structural basis for adaptation of lactobacilli to gastrointestinal mucus. Environ. Microbiol. 16 (2014) 888-903.

Crost E. H., Tailford L. E., Le Gall G., Fons M., Henrissat B., and  Juge N. * Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent. PloS One 8 (2013) e76341.

MacKenzie, D.A., Tailford, L.E., Hemmings, A.M and Juge, N.* Crystal structure of a mucus binding protein repeat reveals an unexpected functional immunoglobulin binding activity. J. Biol. Chem. 284 (2009) 32444-53.

Mukhopadhya I., Morais S., Laverde-Gomez J., Sheridan P. O., Walker A. W., Kelly W., Klieve A. V., Ouwerkerk D., Duncan S. H., Louis P., Koropatkin N., Cockburn D., Kibler R., Cooper P. J., Sandoval C., Crost E., Juge N., Bayer E. A., Flint H. J.. (2018)

Sporulation capability and amylosome conservation among diverse human colonic and rumen isolates of the keystone starch-degrader Ruminococcus bromii.

Environmental Microbiology


View Publication

Sequeira S., Kavanaugh D., MacKenzie D. A., Suligoj T., Walpole S., Leclaire C., Gunning A. P., Latousakis D., Willats W. G. T., Angulo J., Dong C., Juge N.. (2018)

Structural basis for the role of serine-rich repeat proteins fromLactobacillus reuteriin gut microbe-host interactions.

Proceedings of the National Academy of Sciences of the United States of America


View Publication

Leclaire C., Lecointe K., Gunning P. A., Tribolo S., Kavanaugh D. W., Wittmann A., Latousakis D., MacKenzie D. A., Kawasaki N., Juge N.. (2018)

Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins.

FASEB Journal


View Publication

Laverde Gomez J. A., Mukhopadhya I., Duncan S. H., Louis P., Shaw S., Collie-Duguid E., Crost E., Juge N., Flint H. J.. (2018)

Formate cross-feeding and cooperative metabolic interactions revealed by transcriptomics in co-cultures of acetogenic and amylolytic human colonic bacteria.

Environmental Microbiology


View Publication

Latousakis D., Nepravishta R., Rejzek M., Wegmann U., Le Gall G., Kavanaugh D., Colquhoun I. J., Frese S., Mackenzie D. A., Walter J., Angulo J., Field R., Juge N.. (2018)

Serine-Rich Repeat Protein adhesins from Lactobacillus reuteri display strain specific glycosylation profiles

Glycobiology


View Publication

Related News