I have led a Research Team, since 2008, that investigates the glycobiology of host-microbe interactions in the gut.
My previous research focused on the structure-function relationships of plant and microbial glycoenzymes and their potential biotechnological application (stemming from my PhD project on barley amylases in Biochemistry-Molecular Biology of Nutrition, Marseille University, France in 1993) and successive postdoctoral positions on fungal glucoamylases at the Carlsberg Research Institute (EMBO and EU-funding) and Institute of Food Research (Marie-Curie fellowship).
After obtaining a lectureship position in Marseille University in Biochemistry and Molecular Biology (in 1997), I led a research Group on Glycosidases in Marseille (1997-1999) and in Norwich (1999-2004) while on secondment at IFR. I put together and coordinated an EU FP5 project on glycosidases and glycosidase inhibitors in food processing (1999-2003),.I obtained a post-doctoral qualification “Habilitation à Diriger les Recherches” in Marseille back in 2005.
Today my team studies the molecular mechanisms of gut bacteria/mucin interactions in health and disease.
Tailford L. E., Owen C. D., Walshaw J., Crost E. H., Hardy-Goddard J., Le Gall G., de Vos W. M., Taylor G. L. and Juge N.* Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation. Nat. Commun. 6 (2015) 7624.
Kober, O.I., Ahl, D., Pin, C., Holm, L., Carding, S.R. and Juge, N.* γδ T-cell-deficient mice show alterations in mucin expression, glycosylation and goblet cells but maintain an intact mucus layer. Am. J. Physiol. Gastrointest. Liver Physiol. 306 (2014) G582-93.
Etzold, S., Kober, O.I, Mackenzie, D.A., Tailford, L.E., Gunning, A.P., Walshaw, J., Hemmings, A.M. and Juge, N.* Structural basis for adaptation of lactobacilli to gastrointestinal mucus. Environ. Microbiol. 16 (2014) 888-903.
Crost E. H., Tailford L. E., Le Gall G., Fons M., Henrissat B., and Juge N. * Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent. PloS One 8 (2013) e76341.
MacKenzie, D.A., Tailford, L.E., Hemmings, A.M and Juge, N.* Crystal structure of a mucus binding protein repeat reveals an unexpected functional immunoglobulin binding activity. J. Biol. Chem. 284 (2009) 32444-53.