Dr Paul Needs


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Health benefits of dietary polyphenols


I am an organic chemist working with colleagues to study the health benefits of phytochemicals, particularly polyphenols and organosulfur compounds derived from cruciferous vegetables.

Currently I am synthesizing polyphenol human metabolites, and 34-S-labelled derivatives. These are used in cell culture studies, and as mass spectral standards.

Tung WC,Rizzo B,Dabbagh Y,Saraswat S,Romanczyk M,Codorniu-Hernández E,Rebollido-Rios R,Needs PW,Kroon PA,Rakotomanomana N,Dangles O,Weikel K,Vinson J. (2020)

Polyphenols bind to low density lipoprotein at biologically relevant concentrations that are protective for heart disease.

Archives of biochemistry and biophysics

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Anacleto SL,Milenkovic D,Kroon PA,Needs PW,Lajolo FM,Hassimotto NMA. (2020)

Citrus flavanone metabolites protect pancreatic-ß cells under oxidative stress induced by cholesterol.

Food & function, 11, 8612-8624

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González-Domínguez R., Jáuregui O., Needs P. W., Kroon P. A., Andrés-Lacueva C.. (2019)

Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics.

Journal of agricultural and food chemistry

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Traka M., Melchini A., Coode-Bate J., Al-Kadhi O., Shikha S., Defernez M., Troncoso Rey P., Kibblewhite H., O'Neill C., Bernuzzi F., Mythen L., Hughes J., Needs P., Dainty J., Savva G., Mills R., Ball R., Cooper C., Mithen R.. (2019)

Transcriptional changes in prostate of men on active surveillance following a 12-month glucoraphanin-rich broccoli intervention – results from the ESCAPE randomized controlled trial


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Mohos V., Pánovics A., Fliszár-Nyúl E., Schilli G., Hetényi C., Mladenka P., Needs P. W., Kroon P. A., Petho G., Poór M.. (2019)

Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme.

International journal of molecular sciences, 20, 2681-2696

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