I am a Research Scientist in the Kroon group. My research focuses on understanding the mechanisms through which food bioactive compounds and gut microbiota interact to protect against cardio-metabolic diseases; clarifying individual metabo-types. My main objectives aim to address following questions;
- Can food bioactives change gut microbiota’s amount, type and function and does this depend on individual metabo-types?
- If there is a change in the gut microbiota is this associated with a change in metabolic behaviour, related to fermentation and the products of fermentation (for both the microbiome and the host?)
- What is the nature of the functional change for the host i.e. to what extent might this relate to specific products and cell signalling pathways and disease?
I’m also a representative for The Physiological Society
Day P, Burrows L, Richards D, Fountain SJ: Inhibitors of diacylglycerol metabolism suppress CCR2 receptor signalling in human monocytes. Br J Pharmacol 2019. doi: 10.1111/bph.14695
Day PEL, Chambers KF, Winterbone MS, Garcia-Blanco T, Vauzour D, Kroon PA: Validation of control genes and a standardised protocol for quantifying gene expression in the livers of C57BL/6 and ApoE-/- mice. Sci Rep 2018, 8(1):8081. doi: 10.1038/s41598-018-26431-3
Muir, E., M. Raza, C. Ellis, E. Burnside, F. Love, S. Heller, M. Elliot, E. Daniell, D. Dasgupta, N. Alves, P. Day, J. Fawcett, and R. Keynes. Trafficking and processing of bacterial proteins by mammalian cells: Insights from chondroitinase ABC. PLOS ONE 12, e0186759, doi:10.1371/journal.pone.0186759 (2017).
Day PE, Ntani G, Crozier SR , Mahon PA, Inskip H, Cooper C, Harvey NC, Godfrey KM, Hanson MA, Lewis RM , Cleal JK. Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport. PLOS ONE 10.1371/journal.pone.0143653, 2015.
Cleal JK, Day PE*, Crosier SR, Hanson MA, Harvey NCH, Robinson SM, Cooper C, Godfrey KM, and Lewis, RM, SWS team.Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women’s Survey (*equal contribution as first author).