I am a Research Scientist in the Kroon group. My research focuses on understanding the mechanisms through which food bioactive compounds and gut microbiota interact to protect against cardio-metabolic diseases; clarifying individual metabo-types. My main objectives aim to address following questions;
- Can food bioactives change gut microbiota’s amount, type and function and does this depend on individual metabo-types?
- If there is a change in the gut microbiota is this associated with a change in metabolic behaviour, related to fermentation and the products of fermentation (for both the microbiome and the host?)
- What is the nature of the functional change for the host i.e. to what extent might this relate to specific products and cell signalling pathways and disease?
Day P, Burrows L, Richards D, Fountain SJ: Inhibitors of diacylglycerol metabolism suppress CCR2 receptor signalling in human monocytes. Br J Pharmacol 2019. doi: 10.1111/bph.14695
Day PEL, Chambers KF, Winterbone MS, Garcia-Blanco T, Vauzour D, Kroon PA: Validation of control genes and a standardised protocol for quantifying gene expression in the livers of C57BL/6 and ApoE-/- mice. Sci Rep 2018, 8(1):8081. doi: 10.1038/s41598-018-26431-3
Muir, E., M. Raza, C. Ellis, E. Burnside, F. Love, S. Heller, M. Elliot, E. Daniell, D. Dasgupta, N. Alves, P. Day, J. Fawcett, and R. Keynes. Trafficking and processing of bacterial proteins by mammalian cells: Insights from chondroitinase ABC. PLOS ONE 12, e0186759, doi:10.1371/journal.pone.0186759 (2017).
Day PE, Ntani G, Crozier SR , Mahon PA, Inskip H, Cooper C, Harvey NC, Godfrey KM, Hanson MA, Lewis RM , Cleal JK. Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport. PLOS ONE 10.1371/journal.pone.0143653, 2015.
Cleal JK, Day PE*, Crosier SR, Hanson MA, Harvey NCH, Robinson SM, Cooper C, Godfrey KM, and Lewis, RM, SWS team.Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women’s Survey (*equal contribution as first author).