Prof. Richard Mithen

Research Leader

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Following a PhD in plant genetics from the University of East Anglia, I worked on the collection, conservation and use of wild crop relatives in south central Africa.

Subsequently, I  led a research group at the John Innes Centre in plant genetics but with an increasing interest in the interface between plant science and human health research.

I became Professor of Crop Science at the University of Nottingham in 1999, and moved to Institute of Food Research in 2003 where I lead the Food and Health programme.  My main research interests are in human nutrition and the role of plant specialised metabolites in promoting and maintaining human health.


Key Publications

Armah CN, Traka MH, Dainty JR, Defernez M, Janssens A, Leung W, Doleman JF, Potter JF and Mithen RF (2013) A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function. American Journal of Clinical Nutrition 78, 712-722

Traka, MH, Saha S, Huseby S, Kopriva S, Walley PG, Braker GC, Moore J, Mero G, van den Bosch F, Constant H, Kelly L, Schepers H, Boddupalli S and Mithen RF (2013). Genetic regulation of glucoraphain accumulation in Beneforte broccoli. New Phytologist 198, 1085-95 *

Traka MH, Mithen RF. (2011) Plant Science and Human Nutrition: Challenges in assessing the health promoting activities of phytochemicals. Plant Cell. 2011 Jul;23(7):2483-97.

Traka M, Melchini A and Mithen RF (2014)  Sulforaphane and prostate cancer interception. Drug Discovery Today 19(9):1488-92.

Doleman J., Grisar G., Van Liedekerke L., Saha S., Roe M., Tapp H., Mithen R.. (2017)

The contribution of alliaceous and cruciferous vegetables to dietary sulphur intake.

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Davidson R., Gardner S., Jupp O., Bullough A., Butters S., Watts L., Donell S., Traka M., Saha S., Mithen R., Peffers M., Clegg P., Bao Y., Cassidy A., Clark I.. (2017)

Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint.

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Al Kadhi O., Traka M., Melchini A., Troncoso-Rey P., Jurkowski W., Defernez M., Pachori P., Mills R. D., Ball R. Y., Mithen R.. (2017)

Increased transcriptional and metabolic capacity for lipid metabolism in the peripheral zone of the prostate may underpin its increased susceptibility to cancer.

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Kadhi O., Melchini A., Defernez M., Mills R., Ball R., Traka M., Mithen R.. (2015)

Global Metabolite profiling of the peripheral and transition zones of the prostate.

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