Dr Roxana Zamudio Zea
Epidemiology, genomics and antimicrobial resistance of bacteria
I am a geneticist with experience in the fields of human population genetics, microbial genomics and bioinformatics.
Currently, I am a Research Scientist within Dr. Alison Mather’s group. My present role in the Mather Group is focused on resistance to extended-spectrum cephalosporin (ESC) drugs in bacteria. This project involves a combination of approaches, including whole genome sequencing (WGS), bioinformatics analyses of large datasets and statistical modelling to identify major transmission pathways of ESC resistance between bacteria, between host species, and between countries.
I was a Research Associate in the Department of Genetics and Genome Biology at the University of Leicester, where I worked on the genomic diversity of Helicobacter pylori from Cape Verde. I further carried out genome projects in phage genomics in H. pylori, mobile elements in Acinetobacter baumannii, biocide and metal resistance in Staphylococcus epidermidis, phylogenetic analysis and antimicrobial resistance (AMR) in Pseudomonas aeruginosa, and spread and genome evolution in Listeria monocytogenes.
I have a PhD and MSc in Genetics from the Federal University of Minas Gerais, Brazil, developing a population structure analysis and association study to susceptibility to gastric cancer in the Peruvian population. I completed my Bachelor degree in Biology from the Universidad Nacional del Altiplano, Peru. For the experimental undergraduate thesis work I went to the Universidad Peruana Cayetano Heredia, Peru, where I was involved in a project on vaccine candidate proteins for swine cysticercosis.
I have experience and interest in microbial genomics, bioinformatics, AMR, Python (beginner level), bash and R programming.
Zamudio R, Hijazi K, Joshi C, Aitken E, Oggioni MR, Gould IM. Phylogenetic analysis of resistance to ceftazidime/avibactam, ceftolozane/tazobactam and carbapenems in piperacillin/tazobactam-resistant Pseudomonas aeruginosa from cystic fibrosis patients. Int J Antimicrob Agents. 2019 Mar 1. pii: S0924-8579(19)30052-4. Doi: 10.1016/j.ijantimicag.2019.02.022
Zamudio R, Oggioni MR, Gould IM, Hijazi K. Time for biocide stewardship? (Correspondence) Nature Microbiology. 2019 Feb 25. Doi: 10.1038/s41564-019-0360-6
Al-Jabri Z, Zamudio R, Horvath-Papp E, Ralph JD, Al-Muharrami Z, Rajakumar K, Oggioni MR. Integrase-Controlled Excision of Metal-Resistance Genomic Islands in Acinetobacter baumannii. Genes (Basel). 2018 Jul 20;9(7). pii: E366. Doi:10.3390/genes9070366
Zamudio R, Pereira L, Rocha CD, Berg DE, Muniz-Queiroz T, Sant Anna HP, Cabrera L, Combe JM, Herrera P, Jahuira MH, Leão FB, Lyon F, Prado WA, Rodrigues MR, Rodrigues-Soares F, Santolalla ML, Zolini C, Silva AM, Gilman RH, Tarazona-Santos E, Kehdy FS. Population, Epidemiological, and Functional Genetics of Gastric Cancer Candidate Genes in Peruvians with Predominant Amerindian Ancestry. Dig Dis Sci. 2016 Jan;61(1):107-16. Doi: 10.1007/s10620-015-3859-6
Pereira L, Zamudio R, Soares-Souza G, Herrera P, Cabrera L, Hooper CC, Cok J, Combe JM, Vargas G, Prado WA, Schneider S, Kehdy F, Rodrigues MR, Chanock SJ, Berg DE, Gilman RH, Tarazona-Santos E. Socioeconomic and nutritional factors account for the association of gastric cancer with Amerindian ancestry in a Latin American admixed population. PLoS One. 2012;7(8):e41200. Doi: 10.1371/journal.pone.0041200
Lineage-specific evolution and gene flow in Listeria monocytogenes are independent of bacteriophages
Environmental Microbiology, 15