Dr Shikha Saha

Researcher

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Optimising nutrient release from plant-based foods

I have extensive knowledge of analytical chemistry, especially chromatography (reversed phase, normal phase, chiral phase, mixed mode, and ion-exchange), spectroscopy (UV, fluorescence, IR, and NMR), and liquid chromatography–mass spectrometry (LC-MS and LC-MS/MS) techniques.

My work as a senior analytical scientist at the Food & Health Programme involves sample preparation, identification of unknown compounds in different matrices, protein-specific peptide identification, and quantitative analysis of wide range of phytochemicals in plant or biological fluids of human and animal origins.

I am responsible for the development of novel analytical methods for the analysis of plant, food, microbial and human metabolites.

I am responsible for training and supervising post-graduate students, visiting scientists and post-docs that are using HPLC, LC-MS and LC-MS/MS techniques as part of their research projects.

I liaise extensively with external contractors regarding all aspects of equipment maintenance, and with obtaining information regarding procurement of new instrumentation.

Beasy G, Bernuzzi F, Day-Walsh P, Tronsco-Rey P, Defernez M, Saha S, Mithen RF, Traka MH, Kroon PA. (2025)

S-Methyl Methanethiosulfonate, the Main Human Metabolite of S-Methyl-L-Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells

Molecular Nutrition & Food Research, e70008


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Beaudry-Richard A, Abdelhak A, Saloner R, Sacco S, Montes SC, Oertel FC, Cordano C, Jabassini N, Ananth K, Gomez A, Keihani A, Chapman M, Javvadi S, Saha S, Staffaroni A, Songster C, Warren M, Boscardin JW, Kramer J, Miller B, Miller JW, Green R, Green AJ. (2025)

Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults.

Annals of neurology


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Hill C, Connolly E, Zhong L, Muka T, Shafaei A, Balmer L, Hayhoe A, Saha S, Woodman R, Lewis J, Hodgson J, Blekkenhors L. (2024)

Development of a food composition database for the estimation of dietary S-methyl cysteine sulfoxide from vegetables.

Journal of Food Composition and Analysis, 130


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Davidson R, Watts L, Beasy G, Saha S, Kroon P, Cassidy A, Clark A, Fraser W, Mcnamara I, Kingsbury S, Conaghan P, Clark I, MacGregor . (2023)

AB1194 A proof of principle dietary intervention trial to examine the protective effect of broccoli bioactives, (specifically sulforaphane), on osteoarthritis

Annals of the Rheumatic Diseases


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Bajka BH, Pinto AM, Perez-Moral N, Saha S, Ryden P, Ahn-Jarvi J, van der, Bland C, Berry SE, Ellis PR, Edwards C. (2022)

Enhanced secretion of satiety-promoting gut hormones in healthy humans following consumption of white bread enriched with cellular chickpea flour: A randomized cross-over study

The American Journal of Clinical Nutrition


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Livingstone TL, Saha S, Bernuzzi F, Savva GM, Troncoso-Rey P, Traka MH, Mills RD, Ball RY, Mithen R. (2022)

Accumulation of Sulforaphane and Alliin in Human Prostate Tissue

Nutrients


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