Dr Shikha Saha

Researcher

Contact via email

Food chemistry and human health

I have extensive knowledge of analytical chemistry, especially chromatography (reversed phase, normal phase, chiral phase, mixed mode, and ion-exchange), spectroscopy (UV, fluorescence, IR, and NMR), and liquid chromatography–mass spectrometry (LC-MS and LC-MS/MS) techniques.

My work as a senior analytical scientist at the Food & Health Programme involves sample preparation, identification of unknown compounds in different matrices, protein-specific peptide identification, and quantitative analysis of wide range of phytochemicals in plant or biological fluids of human and animal origins.

I am responsible for the development of novel analytical methods for the analysis of plant, food, microbial and human metabolites.

I am responsible for training and supervising post-graduate students, visiting scientists and post-docs that are using HPLC, LC-MS and LC-MS/MS techniques as part of their research projects.

I liaise extensively with external contractors regarding all aspects of equipment maintenance, and with obtaining information regarding procurement of new instrumentation.

Traka M., Melchini A., Coode-Bate J., Al-Kadhi O., Shikha S., Defernez M., Troncoso Rey P., Kibblewhite H., O'Neill C., Bernuzzi F., Mythen L., Hughes J., Needs P., Dainty J., Savva G., Mills R., Ball R., Cooper C., Mithen R.. (2019)

Transcriptional changes in prostate of men on active surveillance following a 12-month glucoraphanin-rich broccoli intervention – results from the ESCAPE randomized controlled trial

AJCN


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Mithen R., Coode-Bate J., Sivapalan T., Melchini A., Saha S., Needs P., Dainty J., Maicha J. B., Beasy G., Traka M., Mills R., Ball R.. (2019)

Accumulation of Dietary S-Methyl Cysteine Sulfoxide in Human Prostate Tissue.

Molecular nutrition & food research, e1900461


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Ostertag L. M., Philo M., Tapp H. S., Colquhoun I. J., Saha S., Duthie G. G., Kemsley E. K., de Roos B., Kroon P. A., Le Gall G.. (2017)

Acute consumption of flavan-3-ol-enriched dark chocolate affects human endogenous metabolism – a randomized controlled human interventional trial

Journal of Proteome Research, 16, 2516-2526


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Doleman J., Grisar G., Van Liedekerke L., Saha S., Roe M., Tapp H., Mithen R.. (2017)

The contribution of alliaceous and cruciferous vegetables to dietary sulphur intake.

Food Chemistry, 234, 38-45


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Davidson R., Gardner S., Jupp O., Bullough A., Butters S., Watts L., Donell S., Traka M., Saha S., Mithen R., Peffers M., Clegg P., Bao Y., Cassidy A., Clark I.. (2017)

Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint.

Scientific reports, 7, 3398


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