Dr Shikha Saha

Researcher

Contact via email

Optimising nutrient release from plant-based foods

I have extensive knowledge of analytical chemistry, especially chromatography (reversed phase, normal phase, chiral phase, mixed mode, and ion-exchange), spectroscopy (UV, fluorescence, IR, and NMR), and liquid chromatography–mass spectrometry (LC-MS and LC-MS/MS) techniques.

My work as a senior analytical scientist at the Food & Health Programme involves sample preparation, identification of unknown compounds in different matrices, protein-specific peptide identification, and quantitative analysis of wide range of phytochemicals in plant or biological fluids of human and animal origins.

I am responsible for the development of novel analytical methods for the analysis of plant, food, microbial and human metabolites.

I am responsible for training and supervising post-graduate students, visiting scientists and post-docs that are using HPLC, LC-MS and LC-MS/MS techniques as part of their research projects.

I liaise extensively with external contractors regarding all aspects of equipment maintenance, and with obtaining information regarding procurement of new instrumentation.

Redha AA, Kroon PA, Saha S, Moreno DA, Sun KK, Bows JR, Cozzolino D, Nash GR, Gidley MJ, Torquati L. (2026)

Modulation of human gut microbiota with Lactiplantibacillus plantarum supplementation and its impact on sulforaphane bioavailability.

Proceedings of the Nutrition Society, 84, E270


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Eldridge B, Javvadi S, Perez-Moral N, Sweetman J, De Barros Dantas L, Saha S, Lynch DA, Hunt T, Clough SE, Toussaint J, Worrall A, Manzoni LR, Robinson N, Franklin KA, Edwards C, Clarke J, Farmer J, Warren M, Dodd AN. (2026)

Addressing Vitamin B12 deficiency through aeroponic fortification of a salad crop (Pisum sativum)

Communications Biology


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Cai M, Tejpal S, Tashkova M, Ryden P, Perez-Moral N, Saha S, Garcia Perez, Serrano Contreras, Wist J, Holmes E, Bernal A, Dou B, Franco Becker, Frost G, Edwards C. (2025)

Upper-Gastrointestinal Tract Metabolite Profile Regulates Glycaemic and Satiety Responses to Meals with Contrasting Structure  

Nature Metabolism


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Day-Walsh P, Saha S, Rodriguex-Cuenca S, Bittor J, Angelova D, Kroon PA, Cook E, Stephens K, Charnock-Jones DS. (2025)

Taxonomic Characterisation of Choline and Carnitine Utilising species in Adverse Pregnancy Outcomes and the Impact of Their Trimethylamine Metabolites on Placental Function.

Reproductive Sciences, 32, 213A


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Beasy G, Bernuzzi F, Day-Walsh P, Tronsco-Rey P, Defernez M, Saha S, Mithen RF, Traka MH, Kroon PA. (2025)

S-Methyl Methanethiosulfonate, the Main Human Metabolite of S-Methyl-L-Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells

Molecular Nutrition & Food Research, e70008


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Beaudry-Richard A, Abdelhak A, Saloner R, Sacco S, Montes SC, Oertel FC, Cordano C, Jabassini N, Ananth K, Gomez A, Keihani A, Chapman M, Javvadi S, Saha S, Staffaroni A, Songster C, Warren M, Boscardin JW, Kramer J, Miller B, Miller JW, Green R, Green AJ. (2025)

Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults.

Annals of neurology


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Hill C, Connolly E, Zhong L, Muka T, Shafaei A, Balmer L, Hayhoe A, Saha S, Woodman R, Lewis J, Hodgson J, Blekkenhors L. (2024)

Development of a food composition database for the estimation of dietary S-methyl cysteine sulfoxide from vegetables.

Journal of Food Composition and Analysis, 130


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