Prof. Simon Carding

Research Leader

Contact via email

Upon completing postgraduate work at the Medical Research Council’s Clinical Research Centre in Harrow, I “emigrated” to the USA to take up a postdoctoral position at New York University School of Medicine, and then at Yale University as a Howard Hughes Fellow in the Immunobiology Group at Yale University with Profs Kim Bottomly and Charlie Janeway Jr. While at Yale an interest in gamma-delta (γδ) T cells was acquired working closely with Adrian Hayday on molecular genetics and then with Prof. Peter Doherty to establish their role in (viral) infectious disease. I left Yale after five years to take up a faculty position at the University of Pennsylvania in Philadelphia where I developed a research interest in mucosal and GI-tract immunology, performing studies in germfree mice with Prof John Cebra that helped establish the role of gut microbes in the aetiology of inflammatory bowel disease (IBD).

After 15 years in the USA, I returned to the UK to take up the Chair in Molecular Immunology at the University of Leeds where I established a new research programme on commensal gut bacteria and Bacteroides genetics leading to the development of a Bacteroides drug delivery platform that is being used for developing new interventions for IBD and for mucosal vaccination.

In 2008 I was recruited by UEA and IFR to develop a gut research programme, taking up the Chair of Mucosal Immunology at UEA-MED and the position of head of the Gut Biology Research Programme at IFR, which later became part of the Gut Health and Food Safety (GHFS) Programme. GHFS research covers a broad area of gut biology including epithelial cell physiology, mucus and glycobiology, mucosal immunology, commensal microbiology, foodborne bacterial pathogens, and mathematical modelling and bioinformatics. The success of this programme has led to the establishment of the Gut Microbes and Health research programme that is integral to the research agenda of The Quadram Institute.

Within these programmes, much of the work undertaken in my research group builds upon that carried out in the USA and latterly in the UK with a major focus on understanding the mechanisms of intestinal microbial (bacterial and viral) tolerance. In particular, identifying the pathways and mediators of microbe-host cross talk and the role they play in establishing and maintaining gut health and in diseases that not only affect the gut but other organ systems. This has led to the development of new research projects relating to the gut-microbiome-brain axis and understanding how the intestinal microbiome impacts on mental health and the development of neurodegenerative diseases, and the intestinal virome and the role that prokaryotic and eukaryotic viruses play in microbial homeostasis and dysbiosis.

Wegmann U., Carvalho A. L., Stocks M., Carding S. R.. (2017)

Use of genetically modified bacteria for drug delivery in humans: Revisiting the safety aspect

Scientific Reports, 7, 2294 (2017)

View Publication

Maclaren O. J., Parker A., Pin C., Carding S. R., Watson A. J. M., Fletcher A. G., Byrne H., Maini P. K.. (2017)

A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.

PLoS Computational Biology, 13, e1005688

View Publication

Clements S. J., Maijo M., Ivory K., Nicoletti C., Carding S. R.. (2017)

Age-Associated Decline in Dendritic Cell Function and the Impact of Mediterranean Diet Intervention in Elderly Subjects.

Frontiers in nutrition, 4, 65

View Publication

Wegmann U., Goesmann A., Carding S. R.. (2016)

Complete Genome Sequence of Bacteroides ovatus V975

Genome Announcements, vol. 4 no. 6 , e01335-16

View Publication

Bernardo D., Durant L., Mann E. R., Bassity E., Montalvillo E., Man R., Vora R., Reddi D., Fahri B., Fernandez-Salazar L., English N. R., Peake S. T. C., Landy J., Lee G. H., Malietzis G., Siaw Y. H., Murugananthan A. U., Hendy P., Sanchez-Recio E., Phillips R. K. S., Garrote J. A., Scott P., Parkhill J., Paulsen M., Hart A. L., Al-Hassi H. O., Arranz E., Walker A. W., Carding S. R., Knight S. C.. (2016)

Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal Colon

Cellular and Molecular Gastroenterology and Hepatology, 2, 2239

View Publication

Horn N., Carvalho A., Overweg K., Wegmann U., Carding S. R., Stentz R.. (2016)

A Novel Tightly Regulated Gene Expression System for the Human Intestinal Symbiont Bacteroides thetaiotaomicron

Frontiers in Microbiology, 7, 1080

View Publication

Related News

QI at Invest in ME Research Conference


ME/CFS talks held in Norwich


Do the Answers to ME/CFS lie within our Gut?


The heat is on for the Chilli ME Challenge


Gut bacteria and mind control: to fix your brain, fix your gut!


Current Vacancies

Applications Close: 02 July 2018

Senior Laboratory Microbiome Technician 1003444

Quadram Institute Bioscience (QIB) is looking to recruit a Senior Laboratory Microbiome Technician to provide support to scientists working...