Prof. Simon Carding

Group Leader

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Gut microbes in health and disease

Upon completing postgraduate work at the Medical Research Council’s Clinical Research Centre in Harrow, I “emigrated” to the USA to take up a postdoctoral position at New York University School of Medicine, and then at Yale University as a Howard Hughes Fellow in the Immunobiology Group at Yale University with Profs Kim Bottomly and Charlie Janeway Jr. While at Yale an interest in gamma-delta (γδ) T cells was acquired working closely with Adrian Hayday on molecular genetics and then with Prof. Peter Doherty to establish their role in (viral) infectious disease. I left Yale after five years to take up a faculty position at the University of Pennsylvania in Philadelphia where I developed a research interest in mucosal and GI-tract immunology, performing studies in germfree mice with Prof John Cebra that helped establish the role of gut microbes in the aetiology of inflammatory bowel disease (IBD).

After 15 years in the USA, I returned to the UK to take up the Chair in Molecular Immunology at the University of Leeds where I established a new research programme on commensal gut bacteria and Bacteroides genetics leading to the development of a Bacteroides drug delivery platform that is being used for developing new interventions for IBD and for mucosal vaccination.

In 2008 I was recruited by UEA and IFR to develop a gut research programme, taking up the Chair of Mucosal Immunology at UEA-MED and the position of head of the Gut Biology Research Programme at IFR, which later became part of the Gut Health and Food Safety (GHFS) Programme. GHFS research covers a broad area of gut biology including epithelial cell physiology, mucus and glycobiology, mucosal immunology, commensal microbiology, foodborne bacterial pathogens, and mathematical modelling and bioinformatics. The success of this programme has led to the establishment of the Gut Microbes and Health research programme that is integral to the research agenda of The Quadram Institute.

Within these programmes, much of the work undertaken in my research group builds upon that carried out in the USA and latterly in the UK with a major focus on understanding the mechanisms of intestinal microbial (bacterial and viral) tolerance. In particular, identifying the pathways and mediators of microbe-host cross talk and the role they play in establishing and maintaining gut health and in diseases that not only affect the gut but other organ systems. This has led to the development of new research projects relating to the gut-microbiome-brain axis and understanding how the intestinal microbiome impacts on mental health and the development of neurodegenerative diseases, and the intestinal virome and the role that prokaryotic and eukaryotic viruses play in microbial homeostasis and dysbiosis.

Jones E., Matthews Z., Gul L., Sudhakar P., Treveil A., Divekar D., Buck J., Wrzesinski T., Jefferson M., Armstrong S., Hall L., Watson A., Carding S., Haerty W., Di Palma F., Mayer U., Powell P., Hautefort I., Wileman T., Korcsmaros T.. (2019)

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Disease Models and Mechanisms

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Carvalho A. L., Miquel-Clopes A., Wegmann U., Jones E., Stentz R., Telatin A., Walker N. J., Butcher W. A., Brown P. J., Holmes S., Dennis M. J., Williamson E. D., Funnell S. G. P., Stocks M., Carding S. R.. (2019)

Use of Bioengineered Human Commensal Gut Bacteria-Derived Microvesicles for Mucosal Plague Vaccine Delivery and Immunization

Clinical and Experimental Immunology

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Carvalho A. L. C., Fonseca S. F., Miquel-Clopes A. M. P., Cross K. C., Kok K. S. K., Wegman U. W., Gil-Cardoso K. G. C., Bentley E. G. B., Al Katy S. A. K., Combes J. L. C., Kipar A. K., Stentz R. S., Stewart J. P. S., Carding S. C.. (2019)

Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract

Journal of Extracellular Vesicles, 8, 1-19

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Miquel Clopes A., Bentley E. G., Stewart J. P., Carding S. R.. (2019)

Mucosal vaccines and technology.

Clinical and experimental immunology, 196, 205-214

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Maijo M., Ivory K., Clements S. J., Dainty J., Jennings A., Gillings R., Fairweather-Tait S., Gulisano M., Santoro A., Franceschi C., Carding S. R., Nicoletti C.. (2018)

One-year consumption of a Mediterranean-like dietary pattern induced small scale but extensive changes of immune cell phenotype, co-receptor expression and innate immune responses in healthy elderly subjects: results from the UK arm of the NU-AGE trial

Frontiers in Physiology

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Newberry F., Hsieh S. Y., Wileman T., Carding S. R.. (2018)

Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?

Clinical Science, 132, 523-542

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Stentz R., Carvalho A., Jones E., Carding S. R.. (2018)

Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body

Biochemical Society Transactions

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Rai S., Arasteh M., Jefferson M., Pearson T., Wang Y., Zhang W., Bicsak B., Divekar D., Powell P. P., Nauman R., Beraza N., Carding S. R., Florey O., Mayer U., Wileman T.. (2018)

The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis.

Autophagy, 1-14

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Applications Close: 25 November 2019

PhD Studentships: Funded via the Norwich Research Park’s Doctoral Training Partnership

The Quadram Institute has 16 PhD studentship opportunities open for applications through the Norwich Research Park Doctoral Training Partnership...