Dr Tamas Korcsmaros

Research Leader

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I started my research work as a high-school student in a biochemist laboratory, and after four years of experimental research work, I graduated as a biologist with a Master in Biochemistry in Budapest, Hungary. During my PhD, I developed a gap-filling signalling network database (http://SignaLink.org) for comparative studies, and established the NetBiol – Network Biology research group to focus on signalling and regulatory networks, especially the regulation of autophagy in cancer. I led the NetBiol group for 4 years. We developed novel databases and web-services to meet key needs of the scientific community, while carrying out research using advanced network analysis. In March 2014, I moved to Norwich to become a Fellow at the Earlham Institute (previously TGAC) with a research leader appointment at the Quadram Institute working on gut-related systems biology projects.

By exploiting the expertise available in the two institutes, I have established a group combining in silico approaches (primarily carried out at EI) with bench work and validation (carried out at QI). Our focus is the application of network biology approaches to uncover the role of microbiota in autophagy regulation in the gut. In my group, we develop and utilise bioinformatics methods for computational analysis, which are then experimentally validated at QI or with collaborators at the UEA. I am working closely with several research groups in the Norwich Research Park, including the QI groups of Rob Kingsley, Lindsay Hall and Simon Carding, EI groups of Federica Di-Palma, Wilfried Haerty, Wiktor Jurkowsky, Iain Macaulay and Rob Davey as well as with UEA groups of Alastair Watson and Tom Wileman. Our major focus is on research projects, but we also provide databases for the community as a service, and carry out translational tool development projects. We develop and maintain three resources that fill important gaps in the landscape of network biology bioinformatics tools: 1) SignaLink; 2) Autophagy Regulatory Network; 3) NRF2ome. SignaLink has been described as among the top ten signalling network databases with >2000 visits/month (Chowdhury and Sarkar, Database, 2015). In addition, we recently released a novel database, SalmoNet, an integrated network resource for 10 Salmonella strains.

I played a major role in organising eight international conferences (each with more than 1000 participants), including FEBS-IUBMB Congress 2005 and World Stress Congress 2007. In 2014, I organised the first Interdisciplinary Signaling Workshop (http://signalingworkshop.org) with more than 80 participants. Here advanced science was combined with informal summer activities to solve multi-disciplinary scientific questions with mostly early-stage scientists and high-level, enthusiastic speakers.

Since 2001, I have been participating as a volunteer in Hungarian and international talent support organisations. I organised more than 10 high-school student research conferences. Between 2004 and 2007, I established a university student leadership program for biology students to organise and manage scientific research-related programs and conferences. Currently, I am the Chairman of the Board of the Research Student Foundation supporting 5000 high-school research students. In addition, I participated in several public awareness programs, including UK’s I’m a Scientist, Get me out of here initiative and the Science Day in Norwich.


Key Publications

Modos D, Krishna CB, Fazekas D, Kubisch J, Brooks J, Marcell I, Szabo MP, Vellai T, Csermely P, Lenti K, Bender A, Korcsmáros T. (2017) Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anti-cancer therapies npj Systems Biology and Applications, 2017; 3 (1)

Turei D, Korcsmáros T, Saez-Rodriguez J. (2016) OmniPath: gateway and guide for literature curated signaling pathway resources. Nature Methods 12:966-967

Türei D, Földvári-Nagy L, Fazekas D, Módos D, Kubisch J, Kadlecsik T, Demeter A, Lenti K, Csermely P, Vellai T, Korcsmáros T. (2015) Autophagy Regulatory Network – a systems-level bioinformatics resource for studying autophagy components and their regulation. Autophagy 11(1):155-65.

Korcsmáros T, Schneider MV, Superti-Furga G. (2017) Next generation of network medicine: interdisciplinary signaling approaches. Integrative Biology (Camb). doi: 10.1039/c6ib00215c.

Kubisch J, Türei D, Földvári-Nagy L, Dunai ZA, Zsákai L, Varga M, Vellai T, Csermely P, Korcsmáros T (2013) Complex regulation of autophagy in cancer – integrated approaches to discover the networks that hold a double-edged sword. Seminars in Cancer Biology 23(4):252-61.

Módos D., Bulusu K. C., Fazekas D., Kubisch J., Brooks J., Marczell I., Szabó P. M., Vellai T., Csermely P., Lenti K., Bender A., Korcsmaros T.. (2017)

Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies.

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Modos D., Brooks J., Fazekas D., Ari E., Vellai T., Csermely P., Korcsmaros T., Lenti K.. (2016)

Identification of critical paralog groups with indispensable roles in the regulation of signaling flow.

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Csályi K., Fazekas D., Kadlecsik T., Türei D., Gul L., Horváth B., Módos D., Demeter A., Pápai N., Lenti K., Csermely P., Vellai T., Korcsmaros T., Varga M.. (2016)

SignaFish: A Zebrafish-Specific Signaling Pathway Resource.

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Finding new cancer drugs in the neighbourhood

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New study unravels critical genes to understand human diseases and support drug discovery

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Omnipath sends strong signal

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Autophagy – A review of techniques

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Tamas Korcsmaros

New software being developed to help answer complex biological questions

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