Dr Teresa Díaz Calvo

Researcher

Contact via email

Bacterial diversity and tropical infections

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I am a postdoctoral researcher with extensive experience in microbiology working on mathematical metabolic modelling of staphylococcal biofilms. Skilled in wet and dry laboratory techniques, I have a background both in industry and academic research and a special interest in metagenomics, metabolism, community modelling and systems biology.

BSc in Veterinary Medicine.

My current research is focused on using genome-scale metabolic modelling to understand how microorganisms adapt to different hosts and niches ultimately causing disease. This work involves the construction, curation and analysis of models for staphylococci to be used as tools to identify the metabolic pathways that allow them to grow in the body, form biofilms and cause infection. It includes applying techniques such as Null Space Analysis, Flux Balance Analysis and Elementary Modes Analysis.

Background:

i) PhD on Metabolic Modelling (Norwich Medical School, UEA, 2016-2020);

ii) Consultant at Health Economics (UEA Consulting Ltd., 2018);

iii) Research Associate working on the establishment of biofilm biological models of Non-aureus Staphylococci (Norwich Medical School, UEA, 2015-2016);

iv) Research Scientist working towards the development of novel DNA-based nanoparticulate antibacterials (Procarta Biosystems Ltd., 2012-2015);

v) Visiting worker at Institute of Food Research studying mucin degradation and Sulphate Reducing Bacteriae (Argo Global Fellowship, 2011);

vi) Trainee working on the molecular epidemiology of bovine tuberculosis (Health Surveillance Centre, VISAVET, UCM, 2011).


Key Publications

Diaz Calvo, Teresa (2020) Investigating the metabolism of non-aureus staphylococci relevant to prosthetic joint infection. Doctoral thesis, University of East Anglia. URI: https://ueaeprints.uea.ac.uk/id/eprint/76715

Garcia-Gutierrez, E., Walsh, J.C., Sayavedra, L., Díaz-Calvo, T., Thapa, D., Ruas-Madiedo, P., Mayer, J.M., Cotter, D.P., Narbad, A. (2020). Genotypic and phenotypic characterization of fecal Staphylococcus epidermidis isolates suggests plasticity to adapt to different human body sites . Frontiers in Microbiology. DOI: 10.3389/fmicb.2020.00688

Mamusa, M., Sitia, L., Barbero, F., Ruyra, A., Calvo, T.D., Montis, C., Gonzalez-Paredes, A., Wheeler, G., Morris, C., McArthur, M. and Berti, D. (2017). Cationic liposomal vectors incorporating a bolaamphiphile for oligonucleotide antimicrobials. Biochimica et Biophysica Acta (BBA) – Biomembranes, 1859(10), pp.1767-1777. DOI: 10.1016/j.bbamem.2017.06.006

Marín-Menéndez, A., Montis, C., Díaz-Calvo, T., Carta, D., Hatzixanthis, K., Morris, C., McArthur, M. and Berti, D. (2017). Antimicrobial Nanoplexes meet Model Bacterial Membranes: the key role of Cardiolipin. Scientific Reports, 7(1). DOI: 10.1038/srep41242