Dr Tristan Seecharran


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Glycobiology of host-microbe interactions in the gut

I am a Postdoctoral Scientist in Prof. Nathalie Juge’s group within the Gut Microbes & Health programme. My research project will examine a novel bacterial mechanism of utilising mucin-derived sialic acid. I will test the hypothesis that intramolecular trans-sialidase mediated metabolism of a trans-glycosylation product in gut bacteria provides a competitive nutritional advantage to the gut bacteria, and investigate how this directly affects the level of sialic acid in the gut and impact on pathogens in vivo.

Prior to joining the institute, I carried out my undergraduate studies in Biomedical Sciences at Brunel University, London. Following this, I achieved an MRes degree with Distinction in Prof Jody Linday’s lab at St George’s University of London. I was then awarded a Vice Chancellor’s scholarship to carry out my PhD research in Dr Alan McNally’s lab at Nottingham Trent University. During my PhD, I studied the population structure of Escherichia coli from non-human environments, as well Yersinia pseudotuberculosis, by combining genomic data with ecology to investigate the evolution of pathogenesis in this model bacterial species.

Key Publications

Seecharran, T., Kalin-Manttari, L., Koskela, K., Nikkari, S., Dickins, B., Corander, J., Skurnik, M., McNally, A. (2017) Phylogeographic Separation and Formation of Sexually Discrete Lineages in a Global Population of Yersinia pseudotuberculosis. Microb Genom. doi: 10.1099/mgen.0.000133

McNally, A., Oren, Y., Kelly, D., Pascoe, B., Dunn, S., Seecharran, T., et al. (2016) Combined Analysis of Variation in Core, Accessory and Regulatory Genome Regions Provides a Super-Resolution View into the Evolution of Bacterial Populations. PLoS Genet 12(9). doi: 10.1371/journal.pgen.1006280