Vinicius Dias Nirello

(he/his)

Research Scientist

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Mechanisms regulating the gut-liver axis during health and disease

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I joined the Beraza group at the Quadram Institute after completing my PhD at the University of Campinas in Brazil. During my PhD, I studied how the gut microbiota influences intestinal epithelial cells, particularly in the colon.

At the Quadram Institute, I am building on this work to better understand how the gut responds to microbial signals, inflammation and tissue damage. I am especially interested in how epithelial changes affect barrier function, tissue repair and communication with immune cells.

My work combines bioinformatics and experimental biology, allowing me to move between sequencing datasets and lab-based models such as intestinal organoids, tissue staining and mouse models. I also contribute to projects investigating gut-liver communication, including how intestinal signals can affect liver injury and regeneration.

Seaman S, Ruiz P, Dias-Nirello V, Martin-Castilla L, Elizalde-Garcia P, Vega-Zuza A, Vegas-Petrina L, Lumbreras-Perales C, Philo M, Moreno-Gonzalez M, Varga-Weisz P, Beraza N. (2026)

Intestinal Sirtuin 1 controls liver regeneration via regulating the intestinal FXR/FGF15 axis in mice.

Cellular and molecular gastroenterology and hepatology


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Dias Nirello, Araújo N, Carvalho de Assis H, Moreno Gonzalez M, Ruiz P, Castro PR, Shealy NG, Shelton C, Font Fernandes M, de Oliveira S, Boroni M, Ryffel B, Byndloss MX, Beraza N, Ramirez Vinolo MA, Varga-Weisz P. (2025)

Microbiota shape the colon epithelium controlling inter-crypt absorptive goblet cells via butyrate-GP R109A signalling.

Gut microbes


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