Yemane Tedros

Postgraduate Student

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Glycobiology of host-microbe interactions in the gut

Lactobacillus reuteri is an inhabitant of the GI tract of mammals and birds and several strains of this species are known to be effective probiotics. The mechanisms by which L. reuteri confers its health‐promoting effects are far from being fully understood, but protection of the mucosal barrier is thought to be important.

My PhD project will test the hypothesis that the ability of L. reuteri strains to colonise the gut and trigger immune response is mediated by protein-glycan interactions occurring between cell-surface adhesins and lectins found at the mucosal interface and immune cells.

Prior to joining the institute, I completed a MSc. Degree in Immunology at Imperial College London, during which I carried out my dissertation project at the the College’s Centre for Molecular Microbiology and Infection, in Professor David Holden’s lab.