A (poly)phenol-rich diet reduces serum and faecal calprotectin in older adults with increased intestinal permeability: the MaPLE randomised controlled trial.

Marino M, Del Bo', Martini D, Perna S, Porrini M, Cherubini A, Gargari G, Meroño T, Hidalgo-Liberona N, Andres-Lacueva C, Kroon PA, Guglielmetti S, Riso P. (2024)

BMC geriatrics

Older subjects are at risk of elevated intestinal permeability (IP) which can lead to immune system activation and low-grade systemic inflammation. Dietary changes are a potential strategy to reduce IP. The MaPLE project evaluated the hypothesis that increasing (poly)phenol intake would beneficially impact on several important markers and pathways related to IP. The objective of the present study was to assess the effects of the MaPLE (poly)phenol-rich diet (PR-diet) on additional IP-related biomarkers and any relationships between biomarker responses.

BMC geriatrics

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