A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial.

Del Bo,Bernardi S,Cherubini A,Porrini M,Gargari G,Hidalgo-Liberona N,González-Domínguez R,Zamora-Ros R,Peron G,Marino M,Gigliotti L,Winterbone MS,Kirkup B,Kroon PA,Andres-Lacueva C,Guglielmetti S,Riso P. (2021)

Clinical nutrition (Edinburgh, Scotland), 40, 3006-3018

Increased intestinal permeability (IP) can occur in older people and contribute to the activation of the immune system and inflammation. Dietary interventions may represent a potential strategy to reduce IP. In this regard, specific food bioactives such as polyphenols have been proposed as potential IP modulator due to their ability to affect several critical targets and pathways that control IP. The trial aimed to test the hypothesis that a polyphenol-rich dietary pattern can decrease serum zonulin levels, an IP surrogate marker involved in tight junction modulation, and can beneficially alter the intestinal microbiota, and IP-associated biochemical and clinical markers in older subjects.

Clinical nutrition (Edinburgh, Scotland), 40, 3006-3018

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