A profile-based method for identifying functional divergence of orthologous genes in bacterial genomes.

Wheeler N. E., Barquist L., Kingsley R. A., Gardner P. P.. (2016)

Bioinformatics, 32, 3566-3574

Next generation sequencing technologies have provided us with a wealth of information on genetic variation, but predicting the functional significance of this variation is a difficult task. While many comparative genomics studies have focused on gene flux and large scale changes, relatively little attention has been paid to quantifying the effects of single nucleotide polymorphisms and indels on protein function, particularly in bacterial genomics.

Bioinformatics, 32, 3566-3574

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