A putative anti-inflammatory role for TRPM8 in irritable bowel syndrome-An exploratory study.

Peiris M, Weerts ZZRM, Aktar R, Masclee AAM, Blackshaw A, Keszthelyi D. (2021)

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

Chronic and recurring pain is a characteristic symptom in irritable bowel syndrome (IBS). Altered signaling between immune cells and sensory neurons within the gut may promote generation of pain symptoms. As transient receptor potential melastatin 8 (TRPM8) agonists, such as L-menthol in peppermint oil, have shown to attenuate IBS pain symptoms, we began investigating potential molecular mechanisms.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

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