Accumulation of Dietary S-Methyl Cysteine Sulfoxide in Human Prostate Tissue.

Mithen R., Coode-Bate J., Sivapalan T., Melchini A., Saha S., Needs P., Dainty J., Maicha J. B., Beasy G., Traka M., Mills R., Ball R.. (2019)

Molecular nutrition & food research, e1900461

Observational studies have associated consumption of cruciferous vegetables with reduced risk of prostate cancer. This effect has been associated with the degradation products of glucosinolates - thioglycosides that accumulate within crucifers. The possible role of S-methyl cysteine sulfoxide, a metabolite that also accumulates in cruciferous vegetables, and its derivatives, in cancer prevention is relatively unexplored compared to glucosinolate derivatives. We test the hypothesis that consuming a broccoli soup results in the accumulation of sulfate (a SMCSO derivative) and other broccoli-derived metabolites in prostate tissue.

Molecular nutrition & food research, e1900461

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