An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution.

Waddington C. S., Darton T. C., Jones C., Haworth K., Peters A., John T., Thompson B. A., Kerridge S. A., Kingsley R. A., Zhou L., Holt K. E., Yu L. M., Lockhart S., Farrar J. J., Sztein M. B., Dougan G., Angus B., Levine M. M., Pollard A. J.. (2014)

Clinical Infectious Diseases, 58, 1230-40

Typhoid fever is a major global health problem, the control of which is hindered by lack of a suitable animal model in which to study Salmonella Typhi infection. Until 1974, a human challenge model advanced understanding of typhoid and was used in vaccine development. We set out to establish a new human challenge model and ascertain the S. Typhi (Quailes strain) inoculum required for an attack rate of 60%-75% in typhoid-naive volunteers when ingested with sodium bicarbonate solution.

Clinical Infectious Diseases, 58, 1230-40

View Publication