Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease.

Durant L., Stentz R., Noble A., Brooks J., Gicheva N., Reddi D., O'Connor M. J., Hoyles L., McCartney A. L., Man R., Pring E. T., Dilke S., Hendy P., Segal J. P., Lim D. N. F., Misra R., Hart A. L., Arebi N., Carding S. R., Knight S. C.. (2020)

Microbiome, 8, 88

Bacteroides thetaiotaomicron (Bt) is a prominent member of the human intestinal microbiota that, like all gram-negative bacteria, naturally generates nanosized outer membrane vesicles (OMVs) which bud off from the cell surface. Importantly, OMVs can cross the intestinal epithelial barrier to mediate microbe-host cell crosstalk involving both epithelial and immune cells to help maintain intestinal homeostasis. Here, we have examined the interaction between Bt OMVs and blood or colonic mucosa-derived dendritic cells (DC) from healthy individuals and patients with Crohn's disease (CD) or ulcerative colitis (UC).

Microbiome, 8, 88

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